Sirtuin3 in Neurological Disorders

Abstract

Abstract:: Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative disorders and also regulate the inflammatory process, protein aggregation, etc. The relation between Sirtuins with that of the nervous system and neurodegeneration are widely studied consequently. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of Sirtuins can be altered by using small molecules that would be developed into drugs and it is proven that manipulation of SIRT1 activity influences neurodegenerative disease models. They are especially thrilling since using small molecules, which would be developed into a drug, it is feasible to alter the activities of sirtuins. Different functions of Sirtuins are depended upon their subcellular localization. In this review paper, we are discussing different Sirtuins, differential expression of sirtuins, and expression of sirtuin in the brain and briefly about sirtuin3 (SIRT3).

Honokiol, an inducer of sirtuin‐3, protects against non‐steroidal anti‐inflammatory drug‐induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury

“…As the mitochondrial guardian, Sirt3 controls mitochondrial protein stability to regulate antioxidant defence, structural dynamics, biogenesis, mtDNA repair and metabolism primarily through the deacetylation of target proteins including FOXO3a, OGG1, OPA1, SOD2, pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, succinate dehydrogenase, Ku70, GSK3β, mitochondrial trifunctional protein and phosphofructokinase (Murugasamy et al, 2022; Zhang et al, 2020). Loss of Sirt3 has been critically implicated in diverse pathologies involving mitochondrial structural and functional defects, leading to metabolic and bioenergetic problems (Peng et al, 2022; Sherin et al, 2021; Wu et al, 2019; Zhang et al, 2020). As a result, metabolically active tissues are susceptible to Sirt3 deficiency (Dittenhafer‐Reed et al, 2015; Zhang et al, 2020).…”