Sirtuin-1 - Mediated NF-κB Pathway Modulation to Mitigate Inflammasome Signaling and Cellular Apoptosis is One of the Neuroprotective Effects of Intra-arterial Mesenchymal Stem Cell Therapy Following Ischemic Stroke

Sarmah, Deepaneeta; Datta, Aishika; Kaur, Harpreet; Kalia, Kiran; Borah, Anupom; Rodriguez, Anne‐Marie; Yavagal, Dileep R.; Bhattacharya, Pallab

doi:10.1007/s12015-021-10315-7

Cited by 32 publications

(53 citation statements)

References 78 publications

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“…422 Stem cell therapies also attenuate ischemia-induced injuries, potentially through the SIRT/NF-κB signaling pathway. 423 Finally, an in vitro study revealed that regulation of the miRNA-29b/SIRT1/PPAR-γ coactivator 1 alpha axis ameliorated oxygen-glucose deprivation-induced cell apoptosis, thus protecting cells from ischemia. 424 All these reveal the potential of therapeutics against cellular apoptosis in ischemic stroke.…”

Section: Pathophysiology and Signaling Pathways Involved In Ischemic ...mentioning

confidence: 99%

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Qin

Yang

Chu

et al. 2022

Sig Transduct Target Ther

235

130

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Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the disease. In recent years, efforts have been made to understand the pathophysiology of ischemic stroke, including cellular excitotoxicity, oxidative stress, cell death processes, and neuroinflammation. In the meantime, a plethora of signaling pathways, either detrimental or neuroprotective, are also highly involved in the forementioned pathophysiology. These pathways are closely intertwined and form a complex signaling network. Also, these signaling pathways reveal therapeutic potential, as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic stroke. In this review, we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate in. Therapeutic approaches targeting these signaling pathways, which are associated with the pathophysiology mentioned above, are also discussed. Meanwhile, clinical trials regarding ischemic stroke, which potentially target the pathophysiology and the signaling pathways involved, are summarized in details. Conclusively, this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke, and summarize the therapeutic approaches targeted various pathophysiology, with particular reference to clinical trials and future prospects for treating ischemic stroke.

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Section: Pathophysiology and Signaling Pathways Involved In Ischemic ...mentioning

confidence: 99%

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Qin

Yang

Chu

et al. 2022

Sig Transduct Target Ther

235

130

View full text Add to dashboard Cite

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“…Hence, organoids may be a novel research method to explore the mechanism of the inflammasome in regulating liver fibrosis. It is shown that bone marrow-derived mesenchymal stem cells (BM-MSCs) injection could decrease inflammasomes in the ischemic stroke rat model ( 143 ). Therefore, cell therapy by in vivo delivery of BM-MSCs may be helpful to mitigate inflammasomes during the development of liver fibrosis.…”

Section: Future Perspectivesmentioning

confidence: 99%

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

et al. 2022

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Inflammasomes are multiprotein complexes that can sense danger signals and activate caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There are two main canonical and non-canonical signaling pathways that trigger inflammasome activation. Inflammasomes are expressed and assembled in parenchymal and nonparenchymal cells in response to liver injury in the liver. Additionally, the hepatocytes, biliary epithelial cells (cholangiocytes), hepatic stellate cells (HSCs), hepatic macrophages, and liver sinusoidal endothelial cells (LSECs) contribute to liver fibrosis via different mechanisms. However, the underlying mechanism of the inflammasome and pyroptosis in these liver cells in liver fibrosis remains elusive. This review summarizes the activation and function of inflammasome complexes and then discusses the association between inflammasomes, pyroptosis, and liver fibrosis. Unlike other similar reviewers, we will focus on the effect of inflammasome activation and pyroptosis in the various liver cells during the development of liver fibrosis. We will also highlight the latest progress of pharmacological intervention in inflammasome-mediated liver fibrosis.

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“… 214 A large number of studies have shown that SIRT1 mediates NF-κB pathway modulation to mitigate inflammasome signaling and cellular apoptosis. 203 , 214 , 215 For example, SIRT1 overexpression promoted mouse B lymphocytes cell proliferation, inhibited apoptosis, and upregulated pro-inflammatory cytokines by inhibiting the NF-κB pathway. 216 Additionally, activating the NF-κB signaling pathway could ultimately induce apoptosis through regulation of the inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

213

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Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

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Sirtuin-1 - Mediated NF-κB Pathway Modulation to Mitigate Inflammasome Signaling and Cellular Apoptosis is One of the Neuroprotective Effects of Intra-arterial Mesenchymal Stem Cell Therapy Following Ischemic Stroke

Cited by 32 publications

References 78 publications

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

The sirtuin family in health and disease

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