Sirtuin 1 and oral cancer (Review)

Abstract

The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs) consisting of seven members (SIRT1-SIRT7). Over the past few decades, SIRT1 has been the most extensively studied and garnered tremendous attention in the scientific community due to its emerging role in cancer biology. However, its biological role in the regulation of oral cancer is not yet fully understood. Owing to contradictory findings regarding the role of SIRT1 in oral cancer, debate about it continues. The present study discusses the biological roles and potential therapeutic implications of SIRT1 in precancerous oral lesions and oral cancer. Contents 1. Introduction 2. Overview of SIRT1 functions 3. SIRT1 and tumour development 4. Modulation of SIRT1 in oral cancer 5. Therapeutic potential of HDACs in malignancy 6. Future research perspectives and possible therapeutic applications of SIRT1 in oral cancer 7. Concluding remarks

Synergistic Effect of Dietary Betaines on SIRT1-Mediated Apoptosis in Human Oral Squamous Cell Carcinoma Cal 27

“…Cell viability was expressed as number of viable cells following manufacturer's instruction. Cells were treated with increasing volumes of milk (10,15,20 and 30% v/v) for different times. Betaine treatments were performed with increasing concentrations of δVB and γBB (up to 3 mM) in specific complete medium up to 72 h. To study the synergistic effects of δVB and γBB, oral cancer and non-tumor HaCaT cell lines were treated for 24, 48 and 72 h with δVB (2 mM) in the presence of increasing concentrations of γBB (up to 3 mM).…”

“…Under massive levels of DNA damage and loss of tumor suppressors or checkpoints, SIRT1 overexpression promotes cancer formation [15][16][17]. In oral cancer, SIRT1 expression correlated with tumor repression and its downregulation at transcriptional level is linked to malignant transformation, invasion and metastasis [18][19][20][21]. Moreover, in vitro studies on Cal 27 cells and xenograft mouse model support the potential of SIRT1 as tumor suppressor in oral cancer and provide the rationale for the use SIRT1 activators from dietary source in the setting of new prevention strategies [22].…”

Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy

“…The T helper cell (Th)2 immune response and associated cytokines, such as il-4, il-5 and il-13, are known to play important roles in the pathogenesis of asthma (2). a total of seven sirtuin (SirT) family members have been identified in mammals, termed SIRT1 to SIRT7 (3). SIRT1 and SirT2 are found in the nucleus and cytoplasm, whereas SirT3, SirT4 and SirT5 are mitochondrial, and SirT6 and SirT7 are exclusively nuclear (4).…”

Nicotinic-nAChR signaling mediates drug resistance in lung cancer

“…However, SIRT1/2 inhibitor, sirtinol, can increase anticancer potential and chemosensitivity in several cancer cells [102,160,161]. SIRT1 may have contradictory roles in promoting or suppressing in different cell contexts or types of tumor development [162]. Moreover, shikonin causes apoptosis in some lung cancer cell lines via the FOXO3a/EGR1/SIRT1 signaling pathway activation [163].…”