SIRT6 mediates multidimensional modulation to maintain organism homeostasis

Yang, Yueying; Zhu, Man; Liang, Jing; Wang, Hui; Sun, Dejuan; Li, Hua; Chen, Lixia

doi:10.1002/jcp.30791

Cited by 3 publications

(2 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although their functions are very diverse and many studies are still needed to understand their role in each process, it has been described that SIRT1 is involved in inflammation, oxidative stress, cell proliferation, and apoptosis [15,16], while the other nuclear sirtuins, SIRT6 and SIRT7, participate in DNA repair [17] and regulation of gene transcription [18], respectively. Mitochondrial sirtuins SIRT3, SIRT4, and SIRT5 are involved in the response to oxidative stress and metabolic pathways inside this organelle [19].…”

Section: Sirt2 and Agingmentioning

confidence: 99%

Age-Associated Changes of Sirtuin 2 Expression in CNS and the Periphery

Garmendia-Berges,

Sola-Sevilla,

Mera-Delgado

et al. 2023

Biology

View full text Add to dashboard Cite

Sirtuin 2 (SIRT2), one of the seven members of the sirtuin family, has emerged as a potential regulator of aging and age-related pathologies since several studies have demonstrated that it shows age-related changes in humans and different animal models. A detailed analysis of the relevant works published to date addressing this topic shows that the changes that occur in SIRT2 with aging seem to be opposite in the brain and in the periphery. On the one hand, aging induces an increase in SIRT2 levels in the brain, which supports the notion that its pharmacological inhibition is beneficial in different neurodegenerative diseases. However, on the other hand, in the periphery, SIRT2 levels are reduced with aging while keeping its expression is protective against age-related peripheral inflammation, insulin resistance, and cardiovascular diseases. Thus, systemic administration of any known modulator of this enzyme would have conflicting outcomes. This review summarizes the currently available information on changes in SIRT2 expression in aging and the underlying mechanisms affected, with the aim of providing evidence to determine whether its pharmacological modulation could be an effective and safe pharmacological strategy for the treatment of age-related diseases.

show abstract

Section: Sirt2 and Agingmentioning

confidence: 99%

Age-Associated Changes of Sirtuin 2 Expression in CNS and the Periphery

Garmendia-Berges,

Sola-Sevilla,

Mera-Delgado

et al. 2023

Biology

View full text Add to dashboard Cite

show abstract

“…To date, seven types of sirtuins have been identified in mammals (SIRT1-7), all of which have different functions and localizations in cells [1]. SIRT1, SIRT6, and SIRT7 mainly exist in the nucleus, where SIRT1 regulates transcription, chromatin modification, and energy metabolism, while SIRT6 and SIRT7 are related to DNA repair and rDNA transcription [2][3][4]. SIRT3-5 are localized in mitochondria, where they regulate oxidative stress and ATP production in response to caloric restriction [5].…”

Section: Introductionmentioning

confidence: 99%

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

et al. 2022

View full text Add to dashboard Cite

Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with tubulin in the cytoplasm, has its own functions and characteristics. In recent years, studies have increasingly shown that SIRT2 can participate in the regulation of gene expression and regulate signal transduction in the metabolic pathway mainly through its post-translational modification of target genes; thus, SIRT2 has become a key centre in the metabolic pathway and participates in the pathological process of metabolic disorder-related diseases. In this paper, it is discussed that SIRT2 can regulate all aspects of gene expression, including epigenetic modification, replication, transcription and translation, and post-translational modification, which enables SIRT2 to participate in energy metabolism in life activities, and it is clarified that SIRT2 is involved in metabolic process-specific signal transduction mechanisms. Therefore, SIRT2 can be involved in metabolic disorder-related inflammation and oxidative stress, thereby triggering the occurrence of metabolic disorder-related diseases, such as neurodegenerative diseases, tumours, diabetes, and cardiovascular diseases. Currently, although the role of SIRT2 in some diseases is still controversial, given the multiple roles of SIRT2 in regulating physiological and pathological signal transduction, SIRT2 has become a key target for disease treatment. It is believed that with increasing research, the clinical application of SIRT2 will be promoted.

show abstract