SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis

Zhang, Cuiping; Wang, Ke; Hu, Zuojian; Yang, Lujie; Wei, Bin; Li, Shan; Qin, Xue; Yang, Pengyuan; Yu, Hongxiu

doi:10.1007/s13238-020-00709-7

Cited by 6 publications

(4 citation statements)

References 15 publications

(21 reference statements)

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“…Consequently, SIRT-3 activation using Resveratrol ameliorated these pathophysiological observations (Kim et al, 2020), indicating SIRT-3 preserves energetic pathway function during infection. Similarly, SIRT-5 −/− mice exerted susceptibility to Salmonella typhimurium infection due to impaired glucose homeostasis which subsequently enhanced IL-1β production to exacerbate inflammation (Zhang et al, 2020). While this contradicted results from preceding studies reporting that SIRT-5 has a dispensable role in bacterial infection (Heinonen et al, 2018), mice backgrounds and bacterial strains used in both studies were different, potentially influencing outcomes.…”

Section: Pathogens Target Host Cellular Metabolic Pathways Which Are Regulated By Sirtsmentioning

confidence: 81%

NAD+ Degrading Enzymes, Evidence for Roles During Infection

Tan

Doig

2021

Front. Mol. Biosci.

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Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection. The enzymatic cleavage of NAD+ transfers ADP-ribose (ADPr) to substrate proteins generating mono-ADP-ribose (MAR), poly-ADP-ribose (PAR) or O-acetyl-ADP-ribose (OAADPr). These important post-translational modifications have roles in both immune response activation and the advancement of infection. In particular, emergent data show viral infection stimulates activation of poly (ADP-ribose) polymerase (PARP) mediated NAD+ depletion and stimulates hydrolysis of existing ADP-ribosylation modifications. These studies are important for us to better understand the value of NAD+ maintenance upon the biology of infection. This review focuses specifically upon the NAD+ utilising enzymes, discusses existing knowledge surrounding their roles in infection, their NAD+ depletion capability and their influence within pathogenic infection.

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Section: Pathogens Target Host Cellular Metabolic Pathways Which Are Regulated By Sirtsmentioning

confidence: 81%

NAD+ Degrading Enzymes, Evidence for Roles During Infection

Tan

Doig

2021

Front. Mol. Biosci.

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“…This circuit triggers oscillations of STAT3 expression and activation in epithelial cells, producing rhythmic antimicrobial protein expression that affects resistance to Salmonella typhimurium infection [ 43 ]. Perception of microbial ligands by macrophages triggers an increase in glucose metabolism, which provides energy to support antimicrobial inflammation and cytokine production and results in insulin secretion which regulates glucose homeostasis [ 44 ]. The Wnt signaling pathway can regulate intestinal epithelial cell proliferation, maintain the intestinal mucosal barrier’s integrity, induce Paneth cell differentiation, and increase the expression of antimicrobial peptides [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A Study of the Resistance of Hu Sheep Lambs to Escherichia coli F17 Based on Whole Genome Sequencing

Duan,

Su,

et al. 2024

Animals

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This study aims to analyze the whole genome sequencing of E. coli F17 in antagonistic and susceptible Hu sheep lambs. The objective is to investigate the critical mutation loci in sheep and understand the genetic mechanism of sheep resistance to E. coli F17 at the genome level. Antagonist and susceptible venous blood samples were collected from Hu sheep lambs for whole genome sequencing and whole genome association analysis. A total of 466 genes with significant SNPs (p < 1.0 × 10−3) were found. GO and KEGG enrichment analysis and protein interaction network analysis were performed on these genes, and preliminary investigations showed that SNPs on CTNNB1, CDH8, APOD, HCLS1, Tet2, MTSS1 and YAP1 genes may be associated with the antagonism and susceptibility of Hu sheep lambs to E. coli F17. There are still some shortcomings that have not been explored via in vivo and in vitro functional experiments of the candidate genes, which will be our next research work. This study provides genetic loci and candidate genes for resistance of Hu sheep lambs to E. coli F17 infection, and provides a genetic basis for breeding disease-resistant sheep.

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“…Diabetes mellitus is one risk factor for the development of active TB due to impaired production of chemokines and cytokines ( 34 ). A previous study demonstrated that SIRT5 has a potential role in regulating glucose homeostasis, and Sirt5 deficiency mice boost IL-1β production in inflammatory response ( 35 ). These findings provided us with new insight to further explore potential immune mechanisms of Sirt5 in TB development in diabetes patients.…”

Section: Discussionmentioning

confidence: 99%