2017
DOI: 10.18632/aging.101307 View full text |Buy / Rent full text
Has erratum 2018-9-28Comment 2018-1-8Has correction 2018-9-28
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Abstract: The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD+-dependent manner and is implicated in cellular senescence and aging. Here we reveal a novel function of SIRT4 in mitochondrial morphology/quality control and regulation of mitophagy. We report that moderate overexpression of SIRT4, but not its enzymatically inactive mutant H161Y, sensitized cells to mitochondrial stress. CCCP-triggered dissipation of the mitochondrial membrane potential resulted in increased mitocho… Show more

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“…SIRT4 was first identified as a mitochondrial protein that controls energy metabolism, and early studies focused on its role in metabolic diseases and obesity. 14,15 Years later, researchers at Harvard Medical School and the U. S. National Institutes of Health discovered that SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. 16,17 SIRT4 is downregulated in a variety of human malignant tumors, including gastric cancer, colorectal cancer, lung cancer, and liver cancer, confirming its function as a tumor suppressor.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…SIRT4 was first identified as a mitochondrial protein that controls energy metabolism, and early studies focused on its role in metabolic diseases and obesity. 14,15 Years later, researchers at Harvard Medical School and the U. S. National Institutes of Health discovered that SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. 16,17 SIRT4 is downregulated in a variety of human malignant tumors, including gastric cancer, colorectal cancer, lung cancer, and liver cancer, confirming its function as a tumor suppressor.…”
Section: Discussionmentioning
“…S3). Besides its extramitochondrial/centrosomal localization, SIRT4 was observed as described 23,42 in mitochondria using a co-staining against the mitochondrial marker MTC02 (Fig. S4).…”
Section: Sirt4 Localizes At Interphase and Mitotic Centrosomes And Inmentioning
“…During our studies on the expression and mitochondrial function of SIRT4 40,42,43 we noticed an extra-mitochondrial localization of endogenous SIRT4 at centrosomes and in part at the mitotic spindle in confocal laser scanning and spinning disk microscopy-based analyses of various human cell lines. We employed two independent anti-human SIRT4 antibodies, SAB1407208 (Sigma-Aldrich) raised against full-length human SIRT4 (a.a.1-314) and H-234 (sc-135053, Santa Cruz Biotechnology) raised against a N-terminally truncated version of human SIRT4 (a.a. 81-314).…”
Section: Sirt4 Localizes At Interphase and Mitotic Centrosomes And Inmentioning
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