SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling
Mehrnaz Mehrabipour,
Saeideh Nakhaei-Rad,
Radovan Dvorsky
et al.
Abstract:Cellular responses leading to development, proliferation, and differentiation depend on RAF/MEK/ERK signaling, which integrates and amplifies signals from various stimuli for downstream cellular responses. C-RAF activation has been reported in many types of tumor cell proliferation and developmental disorders, necessitating the discovery of potential C-RAF protein regulators. Here, we identify a novel and specific protein interaction between C-RAF among the RAF kinase paralogs, and SIRT4 among the mitochondria… Show more
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