Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53

Jin, Yipeng; Kim, Yeon Jin; Kim, Dae Won; Baek, Kwang‐Hyun; Kang, Bok Yun; Yeo, Chang Yeol; Lee, Kwang Youl

doi:10.1016/j.bbrc.2008.01.114

Cited by 94 publications

(81 citation statements)

References 25 publications

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“…Administration of a SIRT2 inhibitor resulted in increased p53 acetylation [226]. The influence of SIRT2 on p53 appears to be complex; it can either block its trans-activating influence on gene expression (via direct deacetylation) [87], or enhance its degradation [18], sometimes only when working in concert with SIRT1 [153]. SIRT3 is able to modulate p53 degradation mediated by MDM2 (mouse double minute 2 homolog), and the influence p53's role as a metabolic regulator [237].…”

Section: Transcriptional and Post-transcriptional Regulators As Sirtumentioning

confidence: 99%

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Jęśko¹,

Strosznajder²

2016

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A b s t r a c tSirtuins vast number of targets in many cellular compartments, and some display additional enzymatic activities including mono(ADP-ribosyl)ation. SIRTs interact with multiple signalling proteins, transcription factors and enzymes including p53, FOXOs (forkhead box subgroup O), PPARs (peroxisome proliferator-activated receptors), NF-κB, and DNA-PK (DNA-dependent protein kinase). Sirtuins also interact extensively with the family of poly(ADPribose) polymerases (PARPs), a crucial and widespread class of NAD

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Section: Transcriptional and Post-transcriptional Regulators As Sirtumentioning

confidence: 99%

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Jęśko¹,

Strosznajder²

2016

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“…For instance, among the targets of SirT1 are the histone modifications H4K16Ac and H3K9Ac, p53, and the transcription factors FOXO and NF-kB (Luo et al 2001;Vaziri et al 2001;Brunet et al 2004;Motta et al 2004;Vaquero et al 2004;Yeung et al 2004). SirT2 deacetylates H4K16Ac, H3K9Ac, p53, and FOXO, whereas SirT6 targets H3K9Ac and regulates the activity of NF-kB (Vaquero et al 2006;Wang et al 2007;Jin et al 2008;Michishita et al 2008;Kawahara et al 2009). Sirtuins show two associated enzymatic activities that likely diverged from an original one: protein deacetylation and mono[ADP-ribosyl] transferase (mADPRT) (Tanny et al 1999;Imai et al 2000).…”

Section: The Exertion Of Sirtuinsmentioning

confidence: 99%

Calorie restriction and the exercise of chromatin

Vaquero¹,

Reinberg²

2009

Genes Dev.

136

140

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Since the earliest stages of evolution, organisms have faced the challenge of sensing and adapting to environmental changes for their survival under compromising conditions such as food depletion or stress. Implicit in these responses are mechanisms developed during evolution that include the targeting of chromatin to allow or prevent expression of fundamental genes and to protect genome integrity. Among the different approaches to study these mechanisms, the analysis of the response to a moderate reduction of energy intake, also known as calorie restriction (CR), has become one of the best sources of information regarding the factors and pathways involved in metabolic adaptation from lower to higher eukaryotes. Furthermore, responses to CR are involved in life span regulation—conserved from yeast to mammals—and therefore have garnered major research interest. Herein we review current knowledge of responses to CR at the molecular level and their functional link to chromatin.

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“…IL-3 is known to mediate a variety of cellular activities in Ba/F3 cells through Jak/STAT, Ras/Raf/ MAPK, and PI3K/Akt signaling pathways. Furthermore, 14-3-3␤/␥ isoforms through dimerization by interaction with Sirt2 and down-regulation of p53 have been tied to higher survival function (53,54). We have observed the up-regulation of PI3K, Akt, MEK1, p-ERK, p-p38, p-JNK, and PKC as a consequence of ectopic expression of 14-3-3␥, revealing its importance in activating signaling cascades that promote cell survival and proliferation; in contrast, the up-regulation of Bad and Bax were seen with the ablation of 14-3-3␥ both in vivo and in vitro (19,55).…”

Section: -3-3␥ Involvement In Signaling Cascades Of Hematopoietic Cmentioning

confidence: 99%

14-3-3γ Is Stimulated by IL-3 and Promotes Cell Proliferation

Ajjappala

Kim

et al. 2009

The Journal of Immunology

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*IL-3 plays important roles in the growth and survival of hematopoietic progenitor cells, processes modeled in studies of the IL-3-dependent cell line Ba/F3. To gain insights into molecular mechanisms governing cell fate, we examined the patterns of proteins up-regulated following stimulation of Ba/F3 cells with IL-3. Through two-dimensional electrophoresis and proteomicsbased approaches, we identified 11 proteins. Of these, expression of 14-3-3␥ was significantly increased by IL-3 stimulation at both the transcriptional and translational levels. 14-3-3␥ overexpression in Ba/F3 cells abrogated dependence on IL-3 and was associated with activation of PI3K and MAPK signaling cascades, suggesting that the functions of 14-3-3␥ in normal hematopoietic progenitors are to promote survival and growth through the activation of distinct signaling pathways. Additionally, the upregulation of Bax and Bad was seen with the ablation of 14-3-3␥, resulting in cell death. These results indicate that deregulated expression of 14-3-3␥ may contribute to malignant transformation, possibly providing a new target for therapeutic intervention in hematopoietic neoplasms.

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Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53

Cited by 94 publications

References 25 publications

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Calorie restriction and the exercise of chromatin

14-3-3γ Is Stimulated by IL-3 and Promotes Cell Proliferation

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