SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through modulation of Toll-like receptor 4

Cheng, Yuan-Yang; Kao, Chung Lan; Hsin, I.; Hung, Ching Hsia; Wang, Chin Tien; Liu, Ding Hao; Chen, Po Yin; Tsai, Kun Ling

doi:10.1093/jb/mvv041

Cited by 34 publications

(30 citation statements)

References 71 publications

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“…Cheng et al (2015) revealed that exercise activated SIRT1 activity, which reduced NF-κB, TLR-4, IL-1β, IL- 6, IL-8, and TNFα inflammatory activity. A murine sepsis model in C57BL/6 mice injected with LPS stimulated TLR4 and activated SIRT1 , which induced NF-κB p65 deacetylation and deactivation thus inhibiting pro-inflammatory gene expression (Liu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

Clark¹,

Mach²

2017

Front. Physiol.

254

216

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Many physiological changes occur in response to endurance exercise in order to adapt to the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species (ROS) production and acute inflammatory responses. Mitochondria are organelles within each cell that are crucial for ATP production and are also a major producer of ROS and reactive nitrogen species during intense exercise. Recent evidence shows there is a bidirectional interaction between mitochondria and microbiota. The gut microbiota have been shown to regulate key transcriptional co-activators, transcription factors and enzymes involved in mitochondrial biogenesis such as PGC-1α, SIRT1, and AMPK genes. Furthermore, the gut microbiota and its metabolites, such as short chain fatty acids and secondary bile acids, also contribute to host energy production, ROS modulation and inflammation in the gut by attenuating TNFα- mediated immune responses and inflammasomes such as NLRP3. On the other hand, mitochondria, particularly mitochondrial ROS production, have a crucial role in regulating the gut microbiota via modulating intestinal barrier function and mucosal immune responses. Recently, it has also been shown that genetic variants within the mitochondrial genome, could affect mitochondrial function and therefore the intestinal microbiota composition and activity. Diet is also known to dramatically modulate the composition of the gut microbiota. Therefore, studies targeting the gut microbiota can be useful for managing mitochondrial related ROS production, pro-inflammatory signals and metabolic limits in endurance athletes.

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Section: Discussionmentioning

confidence: 99%

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

Clark¹,

Mach²

2017

Front. Physiol.

254

216

View full text Add to dashboard Cite

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“…Sirtinol also reversed the inhibitory effects of ATX on TLR4 activation and the subsequent neuroprotection. Although several studies have reported that SIRT1 could modulate the TLR4/NF-кB pathway, the authors did not analyze the exact molecular mechanisms between them (67,68). In addition, no study has reported that SIRT1 can regulate the TLR4/NF-кB pathway under physiologic and pathologic conditions (i.e., SAH).…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll‐like receptor 4 signaling pathway

Zhang

et al. 2018

The FASEB Journal

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Inflammation plays a key role in the progression of subarachnoid hemorrhage (SAH). Here, we examined the effects of astaxanthin (ATX) on the inflammatory response and secondary damage after SAH and the underlying mechanisms of action. In vivo, a prechiasmatic cistern injection model was established in rats and mice. In addition, neuron-microglia cocultures were exposed to oxyhemoglobin to mimic SAH in vitro. Western blotting revealed that protein expression of TLR4 was markedly increased in microglia at 24 h after SAH, with consequent increases in the downstream molecules myeloid differentiation factor 88 and NF-кB. Treatment with ATX significantly inhibited the TLR4 activation, increased sirtuin 1 expression, and inhibited the subsequent inflammatory response both in vivo and in vitro. ATX also significantly decreased high-mobility group box 1 nuclear translocation and secretion in neurons, an effect that was reversed by the sirtuin 1-specific inhibitor sirtinol. ATX administered 4 h after SAH ameliorated cerebral inflammation, brain edema, and neuronal death and improved neurologic function. ATX reduced neuronal death but did not improve neurologic function in TLR4 knockout mice. These results suggest that ATX reduces the proinflammatory response and secondary brain injury after SAH, primarily by increasing sirtuin 1 levels and inhibiting the TLR4 signaling pathway.-Zhang, X., Lu, Y., Wu, Q., Dai, H., Li, W., Lv, S., Zhou, X., Zhang, X., Hang, C., Wang, J. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.

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“…Stimulation of ST36 acupoint by BVA can decrease chronic constrictive injury of sciatic nerve-induced neuropathic pain by activation of α-adrenoceptros, but not through opioid receptors (Roh et al, 2004). Also, Tsai et al, (2015) suggested that BV injection at a certain acupoints (LI4, SI3, KI3, ST36, BL23, BL40, CB30, GB34, LR3, unilateral GV1) can enhance treatment of canine neurological dysfunction by intervertebral disk disease.…”

Section: Discussionmentioning

confidence: 99%

“…However, Chen and Lariviere (2010) considered that BV having nociceptive and anti-nociceptive effects together this is called a "double-edged sword'. Also, other descending inhibitory systems like GABA, serotonergic and/or cholinergic systems might be involved and Park et al, 2009.…”

Section: Discussionmentioning

confidence: 99%

Role of bee Venom Acupuncture in improving pain and life quality in Egyptian Chronic Low Back Pain patients

2017

J App Pharm Sci

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Chronic non-specific low back pain is considered to be the commonest medical symptom for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. This study was done to detect the effect of bee venom acupuncture (BVA) for controlling of chronic low back pain (CLBP). We compared the effects of BVA on 40 patients with CLBP, pre-and post-treatment. The age of patient ranged from 38 to 65 with history of back pain more than 6 months. The curative effect was measured by scoring of visual analog scale (VAS), Oswestry Disability Index (ODI), serum levels TNFα, IL1β, IL-6, and NF-KB as well as ESR before and after BVA treatment. The obtained results revealed that the application of BVA ameliorated the disturbances induced by CLBP, as it showed a significant improvement in VAS (65%) accompanied with a significant improvement in ODI (75.6%) in all patients. Moreover, BVA treatment resulted in a significant (p<0.05) amelioration in serum level of TNFα (-14%), IL1β (-52%), IL-6 (-53%) and NFKB (-32.6%) and ESR (-39.8%). From the mentioned findings, it could be concluded that BVA performed an improvement in CLBP patients, regarding pain intensity, disability and quality of life supported with improvement in serum levels of TNFα, IL1β, IL-6 and NF-кB and ESR.

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SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through modulation of Toll-like receptor 4

Cited by 34 publications

References 71 publications

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll‐like receptor 4 signaling pathway

Role of bee Venom Acupuncture in improving pain and life quality in Egyptian Chronic Low Back Pain patients

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