SIRT1 overexpression by melatonin and resveratrol combined treatment attenuates premature ovarian failure through activation of SIRT1/FOXO3a/BCL2 pathway

Sevgin, Kubra; Erguven, Pelin

doi:10.1016/j.bbrc.2024.149506

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.149506

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SIRT1 overexpression by melatonin and resveratrol combined treatment attenuates premature ovarian failure through activation of SIRT1/FOXO3a/BCL2 pathway

Kubra Sevgin,

Pelin Erguven

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2024

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Cited by 2 publications

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Regulatory Mechanism of Autophagy in Premature Ovarian Failure

Ding,

Shao,

2024

Cell Biochemistry & Function

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Premature ovarian failure (POF) is intricately linked to cellular fates such as senescence, apoptosis, and impaired granulosa cell (GC) differentiation, each of which contributes to ovarian dysfunction and follicular depletion. Autophagy is essential in preventing POF by maintaining cellular homeostasis through the degradation and recycling of damaged organelles and proteins, thereby preserving ovarian function and preventing follicular depletion. Recent studies have revealed that the targeted regulation and disruption of autophagy through various molecular mechanisms ultimately lead to the pathogenesis of POF. In this review, we provide a comprehensive analysis of the disruption in regulatory mechanisms of autophagy contributing to POF. Specifically, we elucidate the molecular mechanisms that can be targeted to restore autophagy homeostasis, offering therapeutic potential for the treatment of POF.

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Regulatory Mechanism of Autophagy in Premature Ovarian Failure

Ding,

Shao,

2024

Cell Biochemistry & Function

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Discovery and evaluation of novel spiroheterocyclic protective agents via a SIRT1 upregulation mechanism in cisplatin-induced premature ovarian failure

He,

Huang,

Nian

et al. 2024

Bioorganic & Medicinal Chemistry

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SIRT1 overexpression by melatonin and resveratrol combined treatment attenuates premature ovarian failure through activation of SIRT1/FOXO3a/BCL2 pathway

Cited by 2 publications

References 33 publications

Regulatory Mechanism of Autophagy in Premature Ovarian Failure

Regulatory Mechanism of Autophagy in Premature Ovarian Failure

Discovery and evaluation of novel spiroheterocyclic protective agents via a SIRT1 upregulation mechanism in cisplatin-induced premature ovarian failure

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