SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Zhang, Wenyu; Feng, Yanling; Guo, Qiqiang; Guo, Wendong; Xu, Hongde; Li, Xiaoman; Yi, Fei; Guan, Yunqian; Geng, Nanxi; Wang, Ping-yuan; Cao, Longyue L.; O’Rourke, Brian; Jo, Juhyeon; Kwon, Jin-Sook; Wang, Rui-Hong; Song, Xiaoyu; Lee, In Hye; Cao, Liu

doi:10.1038/s41418-019-0369-7

Cited by 58 publications

(49 citation statements)

References 52 publications

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“…In addition, Nrf2-driven transcription stimulates the antioxidant, detoxification, and DNA repair capacity of the cells [ 23 ]. It is important to note that butyrate induces Nrf2 directly through its effect on histone acetylation [ 28 , 29 ].…”

Section: Metabolic Signaling In Cancermentioning

confidence: 99%

Postbiotics, Metabolic Signaling, and Cancer

2021

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Postbiotics are health-promoting microbial metabolites delivered as a functional food or a food supplement. They either directly influence signaling pathways of the body or indirectly manipulate metabolism and the composition of intestinal microflora. Cancer is the second leading cause of death worldwide and even though the prognosis of patients is improving, it is still poor in the substantial part of the cases. The preventable nature of cancer and the importance of a complex multi-level approach in anticancer therapy motivate the search for novel avenues of establishing the anticancer environment in the human body. This review summarizes the principal findings demonstrating the usefulness of both natural and synthetic sources of postbotics in the prevention and therapy of cancer. Specifically, the effects of crude cell-free supernatants, the short-chain fatty acid butyrate, lactic acid, hydrogen sulfide, and β-glucans are described. Contradictory roles of postbiotics in healthy and tumor tissues are highlighted. In conclusion, the application of postbiotics is an efficient complementary strategy to combat cancer.

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Section: Metabolic Signaling In Cancermentioning

confidence: 99%

Postbiotics, Metabolic Signaling, and Cancer

2021

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“…Western blot was performed as previously described [17]. For immunoprecipitation, cell lysates were incubated with antibody and Protein A/G-Sepharose beads (sc-2003, Santa Cruz) overnight at 4 °C.…”

Section: Western Blot and Immunoprecipitationmentioning

confidence: 99%

The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response

Cui¹,

Liu²,

Guo³

et al. 2020

Int. J. Biol. Sci.

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Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, regulates multiple biologic and pathologic processes including mitosis, genomic integrity, cell homeostasis and tumorigenesis. However, the role of SIRT2 in the immune response to cancer remains largely elusive. In this study, we found significantly lower expression of SIRT2 in peripheral T lymphocytes from breast cancer patients when compared to normal individuals. Moreover, SIRT2 levels positively correlated with CD8 + effector memory T (TEM) cells in breast cancer patients. In keeping with these findings, altered T cells differentiation manifested as decreased TEM cells and increased naive T cells were observed in Sirt2 deficient mice. The upregulation of CD8 + TEM by SIRT2 might attribute to the activation of aerobic oxidation as well as the inhibition of GSK3β acetylation in CD8 + T cells. Taken together, these results suggest that SIRT2 participate in tumor immune response by regulating T cell differentiation, which may provide novel insight for tumor prevention and immune therapy.

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“…As the significant nicotinamide adenine dinucleotide-dependent protein deacetylase, sirtuin 1 (SIRT1) is extensively involved in various cellular processes and metabolism 6 , 7 . Our previous work revealed that SIRT1 played important roles in genome stability maintenance 8 , DNA damage response 9 and autophagy 10 . We further realize that SIRT1 not only affects intracellular homeostasis, but also participates in the extracellular microenvironment remodeling.…”

Section: Introductionmentioning

confidence: 99%

The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling

Wang¹,

Guo²,

Yi³

et al. 2021

Int. J. Biol. Sci.

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The sirtuins family is well known by its unique nicotinamide adenine dinucleotide (NAD +)-dependent deacetylase function. The most-investigated member of the family, Sirtuin 1 (SIRT1), accounts for deacetylating a broad range of transcription factors and coregulators, such as p53, the Forkhead box O (FOXO), and so on. It serves as a pivotal regulator in various intracellular biological processes, including energy metabolism, DNA damage response, genome stability maintenance and tumorigenesis. Although the most attention has been focused on its intracellular functions, the regulatory effect on extracellular microenvironment remodeling of SIRT1 has been recognized by researchers recently. SIRT1 can regulate cell secretion process and participate in glucose metabolism, neuroendocrine function, inflammation and tumorigenesis. Here, we review the advances in the understanding of SIRT1 on remodeling the extracellular microenvironment, which may provide new ideas for pathogenesis investigation and guidance for clinical treatment.

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SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Cited by 58 publications

References 52 publications

Postbiotics, Metabolic Signaling, and Cancer

Postbiotics, Metabolic Signaling, and Cancer

The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response

The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling

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