SIRT1 mediates the effect of stress on hypothalamic clock genes and food intake regulators in rainbow trout, Oncorhynchus mykiss

Naderi, Fatemeh; Míguez, Jesús M.; Soengas, José L.; López‐Patiño, Marcos A.

doi:10.1016/j.cbpa.2019.05.021

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Concurrent with previously described responsiveness of teleost POA nonapeptide systems to sex steroids, zebrafish chronically exposed to 1,10 and 30 μg/L Bisphenol A (BPA), a weakly estrogenic compound, as well as 1 μg/L E 2, exhibited complex dose-dependent and sex-specific effects on whole brain nonapeptide and nonapeptide receptor gene expression levels, which corresponded with alterations in social but not overall locomotor behaviour ( 174 , 175 ). Similarly, developmental (2-5dpf) exposure to BPA and its replacement compound Bisphenol S (BPS) in the low μM range revealed non-linear alteration of oxt and Oxt protein abundance in association with quantifiable behavioural disruptions at 21dpf ( 176 , 177 ). There is a need to study the involvement of nonapeptide systems in mediating organizational and/or activational effects of endocrine disrupting chemicals.…”

Section: Translational Aspectsmentioning

confidence: 99%

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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The vertebrate nonapeptide families arginine vasopressin (AVP) and oxytocin (OXT) are considered to have evolved from a single vasopressin-like peptide present in invertebrates and termed arginine vasotocin in early vertebrate evolution. Unprecedented genome sequence availability has more recently allowed new insight into the evolution of nonapeptides and especially their receptor families in the context of whole genome duplications. In bony fish, nonapeptide homologues of AVP termed arginine vasotocin (Avp) and an OXT family peptide (Oxt) originally termed isotocin have been characterized. While reproductive roles of both nonapeptide families have historically been studied in several vertebrates, their roles in teleost reproduction remain much less understood. Taking advantage of novel genome resources and associated technological advances such as genetic modifications in fish models, we here critically review the current state of knowledge regarding the roles of nonapeptide systems in teleost reproduction. We further discuss sources of plasticity of the conserved nonapeptide systems in the context of diverse reproductive phenotypes observed in teleost fishes. Given the dual roles of preoptic area (POA) synthesized Avp and Oxt as neuromodulators and endocrine/paracrine factors, we focus on known roles of both peptides on reproductive behaviour and the regulation of the hypothalamic-pituitary-gonadal axis. Emphasis is placed on the identification of a gonadal nonapeptide system that plays critical roles in both steroidogenesis and gamete maturation. We conclude by highlighting key research gaps including a call for translational studies linking new mechanistic understanding of nonapeptide regulated physiology in the context of aquaculture, conservation biology and ecotoxicology.

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Section: Translational Aspectsmentioning

confidence: 99%

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

et al. 2022

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“…Table S1: The main nutrients of the commercial diet used in this experiment; Table S2: The specific primers used for real-time PCR in this study; Table S3: Proximate composition of juvenile Oncorhynchus mykiss under different experimental treatment; Table S4: Liver fatty acids composition of juvenile Oncorhynchus mykiss under different experimental treatment; Table S5: Serum fatty acids composition of juvenile Oncorhynchus mykiss under different experimental treatment; Table S6: Dorsal muscle fatty acids composition of juvenile Oncorhynchus mykiss under different experimental treatment; Table S7: Gene expression of juvenile Oncorhynchus mykiss under different experimental treatment. References [ 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ] cited in the supplementary materials.…”

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confidence: 99%

Time-Restricted Feeding Could Not Reduce Rainbow Trout Lipid Deposition Induced by Artificial Night Light

Shi

et al. 2022

Metabolites

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Artificial night light (ALAN) could lead to circadian rhythm disorders and disrupt normal lipid metabolism, while time-restricted feeding (TRF) could maintain metabolic homeostasis. In mammals, TRF has been demonstrated to have extraordinary effects on the metabolic regulation caused by circadian rhythm disorders, but studies in lower vertebrates such as fish are still scarce. In this study, the impacts of ALAN on the body composition and lipid metabolism of juvenile rainbow trout were investigated by continuous light (LL) exposure as well as whether TRF could alleviate the negative effects of LL. The results showed that LL upregulated the expression of lipid synthesis (fas and srebp-1c) genes and suppressed the expression of lipid lipolysis (pparβ, cpt-1a, and lpl) genes in the liver, finally promoting lipid accumulation in juvenile rainbow trout. However, LL downregulated the expression of genes (Δ6-fad, Δ9-fad, elovl2, and elovl5) related to long-chain polyunsaturated fatty acid (LC-PUFA) synthesis, resulting in a significant decrease in the proportion of LC-PUFA in the dorsal muscle. In serum, LL led to a decrease in glucose (Glu) levels and an increase in triglyceride (TG) and high-density lipoprotein cholesterol (H-DLC) levels. On the other hand, TRF (mid-dark stage feeding (D)) and mid-light stage feeding (L)) upregulated the expression of both the lipid synthesis (srebp-1c and pparγ), lipolysis (pparα, pparβ, and cpt-1a), and lipid transport (cd36/fat and fatp-1) genes, finally increasing the whole-body lipid, liver protein, and lipid content. Meanwhile, TRF (D and L groups) increased the proportion of polyunsaturated fatty acid (PUFA) and LC-PUFA in serum. In contrast, random feeding (R group) increased the serum Glu levels and decreased TG, total cholesterol (T-CHO), and H-DLC levels, suggesting stress and poor nutritional status. In conclusion, ALAN led to lipid accumulation and a significant decrease in muscle LC-PUFA proportion, and TRF failed to rescue these negative effects.

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Daily Rhythmicity of Hepatic Rhythm, Lipid Metabolism and Immune Gene Expression of Mackerel Tuna (Euthynnus affinis) under Different Weather

Wang

et al. 2022

JMSE

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In order to investigate the rhythmic changes in gene expression in the liver of mackerel tuna (Euthynnus affinis) under sunny and cloudy conditions, this experiment had four sampling times (6:00, 12:00, 18:00 and 24:00) set on sunny and cloudy days to determine the expression of their immune, metabolic and rhythmic genes. The results showed that daily rhythmicity was present within most of the rhythm genes (CREB1, CLOCK, PER1, PER2, PER3, REVERBA, CRY2 and BMAL1), metabolic genes (SIRT1 and SREBP1) and immune genes (NF-kB1, MHC-I, ALT, IFNA3, ISY1, ARHGEF13, GCLM and GCLC) in this study under the sunny and cloudy condition (p < 0.05). The expression levels of CREB1, PER1, PER3, RORA, REVERBA, CRY1 and BMAL1 within rhythm genes were significantly different (p < 0.05) in the same time point comparison between sunny and cloudy conditions at 6:00, 12:00, 18:00 and 24:00; metabolic genes had the expression levels of LPL at 6:00, 12:00, 18:00 and 24:00 in the same time point comparison (p < 0.05); immune genes only had significant differences in the expression levels of IFNA3 at 6:00, 12:00, 18:00 and 24:00 (p < 0.05). This study has shown that rhythm, lipid metabolism and immune genes in the livers of mackerel tuna are affected by time and weather and show significant changes in expression.

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SIRT1 mediates the effect of stress on hypothalamic clock genes and food intake regulators in rainbow trout, Oncorhynchus mykiss

Cited by 3 publications

References 53 publications

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes

Time-Restricted Feeding Could Not Reduce Rainbow Trout Lipid Deposition Induced by Artificial Night Light

Daily Rhythmicity of Hepatic Rhythm, Lipid Metabolism and Immune Gene Expression of Mackerel Tuna (Euthynnus affinis) under Different Weather

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