SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
José Manuel García-Martínez,
Ana Chocarro-Calvo,
Javier Martínez-Useros
et al.
Abstract:Cancer initiation and progression result from both genetic alterations and epigenetic reprograming caused by environmental or endogenous factors which can lead to aberrant cell signalling. Most colorectal cancers (CRC) are linked to the abnormal activation of the Wnt/ β-catenin pathway, whose key feature is the accumulation of acetylated β-catenin protein within the nucleus of colon epithelial cells. Nuclear β-catenin acts as a transcriptional co-activator that alters the expression of many target genes involv… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.