SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy

Ji, Jing; Tao, Pengyu; Wang, Qian; Li, Lingxing; Xu, Yuzhen

doi:10.2174/1871530320666201029143606

Cited by 20 publications

(19 citation statements)

References 88 publications

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“…Neurovascular-related diseases and genes have been extensively studied over the years [26,27]. Coupled with an ever-increasing amount of bioinformatics tools, Bioinformatics is playing an increasingly important role [28,29].…”

Section: Discussionmentioning

confidence: 99%

VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer

Wang

et al. 2021

Computational and Mathematical Methods in Medicine

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Background. To analyze the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and cognitive impairment, explore the relationship between the expression of VEGF family genes and prognosis of patients with HCC, and evaluate the predictive ability of VEGF in cognitive impairment using computerized methods. Methods. VEGF expression in liver cancer tissues and normal tissues was analyzed using bioinformatics methods. The Kaplan-Meier survival analysis method was also used to analyze the relationship between VEGF expression and the prognosis of patients with HCC. Furthermore, immune infiltration assessment and gene set enrichment analysis were performed. Meanwhile, the differential expression of VEGF family genes between patients with Alzheimer’s disease (AD) and healthy controls was also checked. Results. Based on The Cancer Genome Atlas (TCGA) database, the VEGF family genes (VEFGA, VEGFB, VEGFC, and VEGFD) were highly expressed in cancer tissues and were significantly associated with poor prognosis in HCC. In HCC, the VEGF family genes showed significant heterogeneity in their functional and immune infiltration characteristics. Finally, VEGF family genes were identified as prognostic biomarkers in AD and risk prediction markers in HCC. Conclusions. VEGF is highly expressed in patients with HCC and lowly expressed in patients with AD. VEGF has opposite opposing roles in the treatment of tumors and cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer

Wang

et al. 2021

Computational and Mathematical Methods in Medicine

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“…Such is indeed the case in diabetic kidney disease (DKD) whereby oxidative stress is elevated and mitochondrial dysfunction is aggravated, leading to renal injury [ 7 , 8 ]. DKD, also known as diabetic nephropathy [ 9 , 10 , 11 , 12 , 13 ], is a common complication of diabetic mellitus, including both type 1 and type 2 diabetes. While type 1 diabetes is caused by lack of insulin due to pancreatic β cell destruction [ 14 , 15 , 16 ], type 2 diabetes could be caused by insulin resistance or insulin deficiency [ 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

2021

Biomolecules

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Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If left untreated, DKD can advance to end stage renal disease that requires either dialysis or kidney replacement. While numerous mechanisms underlie the pathogenesis of DKD, oxidative stress driven by NADH/NAD+ redox imbalance and mitochondrial dysfunction have been thought to be the major pathophysiological mechanism of DKD. In this review, the pathways that increase NADH generation and those that decrease NAD+ levels are overviewed. This is followed by discussion of the consequences of NADH/NAD+ redox imbalance including disruption of mitochondrial homeostasis and function. Approaches that can be applied to counteract DKD are then discussed, which include mitochondria-targeted antioxidants and mimetics of superoxide dismutase, caloric restriction, plant/herbal extracts or their isolated compounds. Finally, the review ends by pointing out that future studies are needed to dissect the role of each pathway involved in NADH-NAD+ metabolism so that novel strategies to restore NADH/NAD+ redox balance in the diabetic kidney could be designed to combat DKD.

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“…Sirtuin1 (SIRT1), a homolog of Sir2, regulates energy metabolism, longevity, and autophagy in an NAD+-dependent manner ( Ji et al, 2020 ). The sirt1 activity promotes life survival in organisms and protects neuronal cells from oxidative stress ( Salminen and Kaarniranta, 2009 ).…”

Section: The Role Of Autophagy and Its Related Signaling Pathway In D...mentioning

confidence: 99%

Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

Tao

et al. 2022

Front. Pharmacol.

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Dementias is a kind of neurodegenerative disease, which occurs among the aging population. Current therapeutic outcome for dementia is limited. The medical use of herbal plant has a rich history in traditional Chinese medicine practice for thousands of years. Herbal medicine (HM) may provide a positive effect for prevention and treatment in dementia. As an alternative treatment to dementia, there has been a growing interest in HM extracts in scientific community as a result of its promising study results, mainly in animal experiment. At the molecular level, HM extracts trigger autophagy and reduce generation of reactive oxygen species (ROS) while inhibiting inflammation and reduce neurotoxicity. Experiments both in vivo and in vitro have identified certain potential of HM extracts and natural products as an important regulator factor in mediating autophagy, which might contribute to the improvement of dementia. This brief review not only summarizes the mechanism of autophagy in dementia but also offers a general understanding of the therapeutic mechanism of HM extracts in treating dementia and evaluates the potential clinical practice of HM in general.

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SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy

Cited by 20 publications

References 88 publications

VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer

VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia

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