SIRT1 and SIRT6: The role in aging-related diseases

You, Yihui; Liang, Wei

doi:10.1016/j.bbadis.2023.166815

Cited by 23 publications

(7 citation statements)

References 159 publications

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“…SIRT1 plays an important role in the regulation of inflammatory and oxidative injury by reducing the production of proinflammatory cytokines and improving antioxidant defenses [62,63]. Emerging evidence has demonstrated that SIRT1 upregulation inhibits S-AKI progression [64][65][66].…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling

Hu,

Xiang,

Zhang

et al. 2024

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

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Section: Discussionmentioning

confidence: 99%

Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling

Hu,

Xiang,

Zhang

et al. 2024

Folia Histochem Cytobiol.

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“…The pathways and molecules involved in both the tumorigenic and anti-tumorigenic effects of Sirt1 include YAP, FOXO, p53, and miRNAs, whereas the JAK2/STAT3 pathway and ferroptosis are involved in the anti-tumorigenic effect of Sirt6 in gastric cancer. This study focused on ROS-mediated cancer cell death because ROS are associated with a variety of cellular processes involving both Sirt1 and Sirt6 [44,45].…”

Section: Discussionmentioning

confidence: 99%

Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer

Seo,

Ryu,

Cheon

et al. 2024

Cancers

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Background: Gastric cancer, one of the leading causes of cancer-related death, is strongly associated with H. pylori infection, although other risk factors have been identified. The sirtuin (Sirt) family is involved in the tumorigenesis of gastric cancer, and sirtuins can have pro- or anti-tumorigenic effects. Methods: After determining the overall survival rate of gastric cancer patients with or without Sirt6 expression, the effect of Sirt6 upregulation was also tested using a xenograft mouse model. The regulation of Sirt6 and Sirt1, leading to the induction of mouse double minute 2 homolog (MDM2) and reactive oxygen species (ROS), was mainly analyzed using Western blotting and immunofluorescence staining, and gastric cancer cell (SNU-638) death associated with these proteins was measured using flow cytometric analysis. Results: Sirt6 overexpression led to Sirt1 suppression in gastric cancer cells, resulting in a higher level of gastric cancer cell death in vitro and a reduced tumor volume. ROS and MDM2 expression levels were upregulated by Sirt6 overexpression and/or Sirt1 suppression according to Western blot analysis. The upregulated ROS ultimately led to gastric cancer cell death as determined via Western blot and flow cytometric analysis. Conclusion: We found that the upregulation of Sirt6 suppressed Sirt1, and Sirt6- and Sirt1-induced gastric cancer cell death was mediated by ROS production. These findings highlight the potential of Sirt6 and Sirt1 as therapeutic targets for treating gastric cancer.

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“…Aging involves the loss and degradation of various physiologic functions in the organism, and these changes are mainly reflected in the loss of cells and constitutive substances in the tissues and slowing down of the metabolic rate. Therefore, maintaining the normal function of mitochondria to ensure optimal metabolism is critical to slow down the aging process (You and Liang 2023).…”

Section: Sirt1-mediated Regulation Of Senescence Pathwaysmentioning

confidence: 99%

Sirtuins in intervertebral disc degeneration: current understanding

Shen,

Lan,

et al. 2024

Mol Med

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Background Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to a variety of pathological spinal conditions such as disc herniation, spinal stenosis, and scoliosis. IVDD is a leading cause of lower back pain, the prevalence of which increases with age. Recently, Sirtuins/SIRTs and their related activators have received attention for their activity in the treatment of IVDD. In this paper, a comprehensive systematic review of the literature on the role of SIRTs and their activators on IVDD in recent years is presented. The molecular pathways involved in the regulation of IVDD by SIRTs are summarized, and the effects of SIRTs on senescence, inflammatory responses, oxidative stress, and mitochondrial dysfunction in myeloid cells are discussed with a view to suggesting possible solutions for the current treatment of IVDD. Purpose This paper focuses on the molecular mechanisms by which SIRTs and their activators act on IVDD. Methods A literature search was conducted in Pubmed and Web of Science databases over a 13-year period from 2011 to 2024 for the terms “SIRT”, “Sirtuin”, “IVDD”, “IDD”, “IVD”, “NP”, “Intervertebral disc degeneration”, “Intervertebral disc” and “Nucleus pulposus”. Results According to the results, SIRTs and a large number of activators showed positive effects against IVDD.SIRTs modulate autophagy, myeloid apoptosis, oxidative stress and extracellular matrix degradation. In addition, they attenuate inflammatory factor-induced disc damage and maintain homeostasis during disc degeneration. Several clinical studies have reported the protective effects of some SIRTs activators (e.g., resveratrol, melatonin, honokiol, and 1,4-dihydropyridine) against IVDD. Conclusion The fact that SIRTs and their activators play a hundred different roles in IVDD helps to better understand their potential to develop further treatments for IVDD. Novelty This review summarizes current information on the mechanisms of action of SIRTs in IVDD and the challenges and limitations of translating their basic research into therapy.

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SIRT1 and SIRT6: The role in aging-related diseases

Cited by 23 publications

References 159 publications

Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling

Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling

Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer

Sirtuins in intervertebral disc degeneration: current understanding

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