SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress

Li, Xiaoqiang; Wu, Gaofeng; Han, Fangfang; Wang, Kejia; Bai, Xiaozhi; Jia, Yong; Li, Zhenzhen; Cai, Wenju; Zhang, Wanfu; Su, Linlin; Hu, Dahai

doi:10.1016/j.abb.2018.11.016

Cited by 35 publications

(29 citation statements)

References 28 publications

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“…Topical applications of resveratrol to the wounded area of diabetic mice stimulated proliferation and inhibited apoptosis of endothelial cells, leading to accelerated wound healing, while either SIRT1 inhibitor or knockout of SIRT1 abolished the benefits of resveratrol in wound healing [125]. SIRT1-mediated benefits of resveratrol in diabetic wound healing can also be attributable to protection of endothelial cells from oxidative stress [201]. In addition, studies in mice indicate that resveratrol accelerates cutaneous wound healing by upregulation of vascular endothelial growth factor mediated by activation of at least two antioxidant enzymes (thioredoxin-1 and heme oxygenase-1) [123].…”

Section: Woundmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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Section: Woundmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…ERK is a MAPK that has a crucial role in the maintenance of cellular homeostasis, acting in stress and proliferative responses [72] at least in part through Nrf2 activation [73]. Nrf2 is a crucial factor involved in oxidative stress protection mechanisms [74]. Given that, it is involved in the regulation of anti-inflammatory and cell survival genes such as phase II detoxifying/antioxidant enzymes as catalase [75].…”

mentioning

confidence: 99%

Acrocomia aculeata(Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance

Alfredo

Matafome

Iacia

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress is a metabolic disorder linked with several chronic diseases, and this condition can be improved by natural antioxidants. The fruit pulp of the palm Acrocomia aculeata (Jacq.) Lodd. ex Mart. is widely used in the treatment of various illnesses, but as far as we know, there are no reports regarding the properties of its leaves. Thus, we aimed to evaluate the antioxidant activity of A. aculeata leaf extracts obtained with water (EA-Aa), ethanol (EE-Aa), and methanol (EM-Aa) solvents. The extracts were chemically characterized, and their antioxidant activity was assessed through the scavenging of the free radicals DPPH and ABTS. EE-Aa and EM-Aa showed the highest amounts of phenolic compounds and free radical scavenging activity. However, EA-Aa was more efficient to protect human erythrocytes against AAPH-induced hemolysis and lipid peroxidation. Thus, we further show the antioxidant effect of EA-Aa in preventing AAPH-induced protein oxidation, H2O2-induced DNA fragmentation, and ROS generation in Cos-7 cells. Increased levels of Sirt1, catalase, and activation of ERK and Nrf2 were observed in Cos-7 treated with EA-Aa. We also verify increased survival in nematodes C. elegans, when induced to the oxidative condition by Juglone. Therefore, our results showed a typical chemical composition of plants for all extracts, but the diversity of compounds presented in EA-Aa is involved in the lower toxicity and antioxidant properties provided to the macromolecules tested, proteins, DNA, and lipids. This protective effect also proven in Cos-7 and in C. elegans was probably due to the activation of the Sirt1/Nrf2 pathway. Altogether, the low toxicity and the antioxidant properties of EA-Aa showed in all the experimental models support its further use in the treatment of oxidative stress-related diseases.

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“…Notably, diabetic ZDF‐C rats also showed a significant decrease in the levels of sirtuin‐1 (SIRT‐1) (Figure E). SIRT‐1 has been shown to protect against ROS‐mediated oxidative damage in arteries by suppressing NADPH oxidase activation . In fact, inhibition of SIRT‐1 significantly increased vascular superoxide production and enhanced NADPH oxidase activity and mRNA expression of NOX‐4 in aortic rings .…”

Section: Resultsmentioning

confidence: 99%

“…Actually, SIRT‐1 protects against ROS‐mediated oxidative damage by suppressing NOXs activation in the vascular wall . Likewise SIRT‐1 activation also increased the expression levels of the Nuclear factor‐E2 related factor 2 (Nrf2) and its antioxidant target in human endothelial cells …”

Section: Introductionmentioning

confidence: 99%

Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats

Álvarez-Cilleros

López-Oliva

Morales‐Cano

et al. 2019

Molecular Nutrition Food Res

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Scope:The aim of the present study is to investigate the potential protective effect of a cocoa-rich diet on functional and structural vascular alterations in diabetes and the mechanism involved. Methods and results: Male Zucker diabetic fatty (ZDF) rats are fed on a standard (ZDF-C) or cocoa-rich diet (ZDF-Co) from week 10 to 20 of life. Diabetic ZDF-C rats showed increased blood pressure and enhanced aortic stiffness, as demonstrated by the increased pulse pressure and the augmented aortic medial thickness with loss and disruption of elastic fibres. Interestingly, cocoa intake strongly avoided all these adverse effects and reduced aortic oxidative stress. Mechanistically, cocoa diet prevented sirtuin-1 (SIRT-1) depletion and increased NADPH oxidases (NOXs) and reactive oxygen species production as well as reduced active nuclear factor E2 related factor 2 (Nrf2) and their antioxidant products. Conclusion: The results demonstrate for the first time that a cocoa-rich diet strongly prevents aortic stiffening and remodeling in diabetic animals and avoids aortic oxidative stress. It is suggested that this effect could be mediated via its effects on SIRT-1, NOXs, and Nrf2. Conflict of InterestThe authors declare no conflict of interest.

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SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress

Cited by 35 publications

References 28 publications

Role of Resveratrol in Regulating Cutaneous Functions

Role of Resveratrol in Regulating Cutaneous Functions

Acrocomia aculeata(Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance

Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats

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