Compared to Susceptible-Infected-Removed Susceptible (SIRS) systems, where it is supposed that a removed population has lost its immunity after being healed from an infection and moves to the susceptible compartment, the S-Exposed-I-R-S (SEIRS) compartmental models, consider also, the presence of an additional compartment named by the variable E which could represent the number of asymptomatic infected individuals, people who are not yet infectious or just exposed to infection. Based on these assumptions, we devise a multi-regions SEIRS discrete-time model which describes infection dynamics due to the presence of an epidemic in regions that are connected with their neighbors by any kind of anthropological movement. The main goal from this kind of modeling, is to introduce after, controls variables which restrict movements of the infected individuals coming from the vicinity of the region targeted by our control strategy we call here by the travel-blocking vicinity optimal control approach. A grid of colored cells is presented to illustrate the whole domain affected by the epidemic while each cell represents a sub-domain or region. In order to illustrate an example of these SEIRS dynamics, we choose an example of infection which is supposed starting from only one cell located in one of the corners of the grid, while the region aiming to control, is supposed to be located in the 2nd line and 4th column of the grid. It is important to note, this optimization approach could be applied to any cell of the grid, and the source of infection could also be supposed to start from any cell. In fact, the example is presented, just to show the effectiveness of the proposed control strategy when it is applied to a cell with an important number of connections (i.e. with 8 neighboring cells in our simulations).