Sirolimus in a Renal Transplant Recipient Infected With COVID-19: A Blessing in Disguise?

Abstract

Immunocompromised status Is often associated with severe coronavirus infection given the inability of the immune system to combat the deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with multiple comorbidities such as diabetes mellitus, hypertension, and chronic kidney disease along with patients on immunosuppressants or chemotherapy are at higher risk of getting infected during the ongoing pandemic with more probability of adverse outcomes. However, we report a rare case of a renal transplant recipient who was on sirolimus and contracted coronavirus disease (COVID-19). His immunosuppressants were continued and he was managed with antiviral, steroids and low molecular weight heparin and the patient responded well to the treatment and recovered completely after a span of one week. Use of sirolimus in a patient with renal transplant recipient helped in preventing intensification of the severity in COVID-19 attributing to its inhibiting effect on mammalian target of rapamycin (mTOR) which he was using post his renal transplant, therefore, proving to be a blessing in disguise.

Rapid review of virtual rehab in musculoskeletal injuries in athletes

“…Long term repetitive motion injuries are considerable health and economical load. The musculoskeletal disorders construct an fourth significant garner with disorder leads in elderly person (36)(37)(38)(39)(40)(41)(42)(43)(44)(45). This study of virtual reality training protocol which suggests the weight training between it, enhance affliction along with the sport completion otherwise is kinetic and further several conventional practices in the athletes, with acute as well as chronic pain.…”

Robotics in Lower limb Amputate to improve functional activity

“…Burn gangrene, peripheral vascular insufficiency, and serious infections are all caused by extreme heat and cold. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] A.…”

“…21 To determine the degree of adaptation, a 5-point Likert scale with anchors of "not at all adapted" and "totally adapted" at the extremities of the scale was utilised. [26][27][28][29][30][31][32][33][34][35][36]…”

A randomised control trial on the use of bioinstrumentation and rehabilitation technology in hemiplegic patients

“…The experimental group 1 received low frequency (LF) rTMS to the unaffected side's primary motor cortex plus physical therapy (PT), which included activities to improve strength, flexibility, transfers, posture, balance, coordination, and activities of daily living, with a focus on upper limb movements; the experimental group 2 received the same protocol plus NMES to the hand extensor muscles; and the control group received only PT. The activity or inhibition of the afflicted and unaffected primary motor cortex was evaluated using a functional magnetic resonance imaging (fMRI) scan.. [27][28][29][30][31][32][33][34][35] The rehabilitation system used in this study was the FELXO-Arm1 system manufactured by Shanghai Electric GeniKIT Medical Science and Technology Co., Ltd. and comprises hardware and software componentFELXO-Arm1 has five degrees of freedom, which is uncommon in rehabilitative therapeutic devices, and is used to help stroke patients recover UL function. It has three passive joints in the horizontal plane and two active joints in the sagittal plane, comprising a motor and gear, which could provide additional assistance to patients undergoing rehabilitative training.…”