Abstract:Objective: The objective of the present study is to examine the serum stability of siRNA loaded nanoparticles that were prepared with certain polymer and evaluate the influence of different pH values on the in vitro release of siRNA from these particles. Methods: Serum stability of siRNA loaded nanoparticles was studied by incubation in serum free medium and in presence of 10 %, and 25 % serum at 37ºC for 6 h. The unshielded fraction (liable to nucleases) of siRNA was measured by Fluoroskan microplate reader a… Show more
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