Sir Austin Bradford Hill, 1897–1991

Doll, Richard

doi:10.1002/sim.4780120808

Cited by 9 publications

(1 citation statement)

References 124 publications

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“…Temporal relationship is the main critical issue to identify paraneoplastic syndromes, and as a rule, the manifestations must occur during a malignant disease or precede it by no longer than 2 years ( 1 – 3 ). The best evidence for the association between the clinical manifestations and the malignant disease is established retrospectively when the symptoms improve or completely remit with the treatment of the underlining neoplasm ( 1 , 2 ). A spectrum of rheumatologic manifestations can result from a paraneoplastic process and are present in about 7–10% of patients with cancer, including arthritis, lupus-like syndromes, inflammatory myopathies, vasculitis, and hypertrophic osteoarthropathy ( 1 , 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature

Silvério-António

Parlato²,

Martins

et al. 2021

Front. Med.

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A 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints of the hands, wrists, and ankles. Associated symptoms included vomiting, progressive fatigue, and weight loss. Laboratory results showed microcytic anemia, leukocytosis, thrombocytosis, elevated C-reactive protein and erythrocyte sedimentation rate, and rheumatoid factor (RF) and anti-cyclic citrullinated protein (ACPA) antibody positivity. Joints radiographs were normal, without erosions. Upper endoscopy and gastric endoscopic ultrasonography showed a gastric adenocarcinoma with lymphatic involvement. Intraoperatively, peritoneal carcinomatosis was documented, and the patient started palliative chemotherapy. A paraneoplastic seropositive arthritis was assumed, and treatment with low-dose prednisolone and hydroxychloroquine was started. Arthritis remission was achieved and sustained up to 18 months of follow-up, although gastric cancer progression was documented. We describe a unique phenotype of paraneoplastic arthritis (PA) presenting as a seropositive (RF and ACPA positivity) rheumatoid arthritis (RA) with a good response to both low dose corticosteroids and hydroxychloroquine therapy. We also review the literature of PA, mostly the RA-like pattern, and the association between PA and ACPA positivity. This case highlights the importance of considering underlying cancer in elderly male patients, presenting with polyarthritis and systemic symptoms, even in those with ACPA-positive RA-like arthritis.

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Section: Introductionmentioning

confidence: 99%

Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature

Silvério-António

Parlato²,

Martins

et al. 2021

Front. Med.

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Hill's Criteria of Causation

Goodman

Phillips

2005

Encyclopedia of Statistics in Behavioral Science

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The term criteria of causation (or causal criteria ) is often applied to Sir Austin Bradford Hill's (8) list of factors to consider before inferring causation from an observed association. This list is widely taught and cited, despite widespread cautions about the limitations of the list, by Hill and others, and despite lack of evidence that invoking such criteria is useful. This entry describes Hill's views on assessing causation and what others have since said on the subject of causal criteria.

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