Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells

Ponesakki, Ganesan; Noda, Kenji; Manabe, Yuki; Ohkubo, Tadayasu; Tanaka, Yukihisa; Maoka, Takashi; Sugawara, Tatsuya; Hirata, Takashi

doi:10.1016/j.bbagen.2011.02.008

Cited by 155 publications

(95 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They indicated that ROS generation by fucoxanthin played a crucial role. Ganesan et al showed that 10 μM of fucoxanthin caused apoptosis and caspase-3 activation in HL-60 cells (29). Fucoxanthin (0.5 μM) was shown to induce caspase-dependent apoptosis with an increase in BAX and reduction in BCL2, phosphatidylinositol-3-kinase (PI3K) and a phosphorylated form of AKT in HeLa cells (30).…”

Section: Fucoxanthin Inhibits Tumor Cell Growth By Inducing G 1 Cell-mentioning

confidence: 99%

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Satomi

2017

View full text Add to dashboard Cite

Section: Fucoxanthin Inhibits Tumor Cell Growth By Inducing G 1 Cell-mentioning

confidence: 99%

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid

Satomi

2017

View full text Add to dashboard Cite

“…GADD45 and DR5 expression levels were notably increased in Siphonaxanthin treated HL-60 cells (Ganesan et al, 2011).…”

Section: Siphonaxanthin From Green Algaementioning

confidence: 86%

Drugs from Marine Sources: Modulation of TRAIL Induced Apoptosis in Cancer Cells

Farooqı

Attar²,

Gasparri³

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

There have been overwhelming advances in molecular oncology and data obtained through high-throughput technologies have started to shed light on wide ranging molecular mechanisms that underpin cancer progression. Increasingly it is being realized that marine micro-organisms and the biodiversity of plankton are rich sources of various anticancer compounds. Marine derived compounds play major roles in inducing apoptosis in cancer cells. More importantly, various agents have been noted to enhance TRAIL induced apoptosis in cancer cells by functionalizing intrinsic and extrinsic pathways. In this commentary, a list of marine derived compounds reported to induce apoptosis is discussed.

show abstract

“…RBL-2H3 cells 1.2 10 5 cells per well, in 24-well plates , sensitized with anti-DNP IgE were treated with 10 μM of each carotenoid for 4 h. The contents of carotenoids in the cells were quantified using high performance liquid chromatography-photodiode array HPLC-PDA , as described previously 12 . The spike recovery test was used for confirming the absence of any significant differences between the extraction efficiencies of fucoxanthinol, the most polar carotenoid used in this study, and β-carotene, a non-polar carotenoid data not shown .…”

Section: Quanti Cation Of Carotenoidsmentioning

confidence: 99%