SiO2/ZnCl2-Catalyzed Heterocyclic Synthesis: Green, Rapid and Efficient One-Pot Synthesis of 14-H-dibenzo [a, j]Xanthenes, 1,8-Dioxo-octahydroxanthenes and 1,8-Dioxo-Decahydroacridines Under Solvent-Free Conditions

Abstract

A green and highly efficient protocol for the one-pot synthesis of a variety of 14-aryl-14-H-dibenzo [a,j]xanthenes and 9-aryl-1,8-dioxo-octahydroxanthenes has been developed via cyclocondensation of aryl aldehydes with 2-naphthol or dimedone using SiO 2 -ZnCl 2 (silzic) as a reusable heterogeneous catalyst under solvent-free reaction conditions. In addition, a one-pot, threecomponent condensation of aryl aldehydes, dimedone and ammonium acetate or aryl amines has been developed to furnish 9-aryl-1,8-dioxo-decahydroacridines in good to excellent yields under the same reaction conditions.