Sinusoidal Obstruction Syndrome in Critically Ill Patients in the Era of Defibrotide: A Retrospective Multicenter Study

Debureaux, Pierre-Édouard; Darmon, Michaël; Bigé, Naïke; Moreau, Anne; Mokart, Djamel; Morel, Guillaume; Lacan, Claire; Perez, Pierre; Pène, Frédéric; Kouatchet, Achille; Picard, Muriel; Murgier, Martin; Wallet, Florent; Mayaux, Julien; Canet, Emmanuel; Azoulay, Élie; Valade, Sandrine

doi:10.1016/j.jtct.2020.11.016

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many penicillins, carbapenems, and cephalosporins are metabolized and/or excreted through the kidneys. 10 , 29 Lower doses and/or modified dosing intervals are often necessary until the patient’s renal function returns to baseline.…”

Section: Composition and Practices Of A Collaborative Vod/sos Teammentioning

confidence: 99%

“…In some cases, pharmacists recommend not administering certain medications, such as aminoglycosides, whereas recommending dose modifications for others. Many penicillins, carbapenems, and cephalosporins are metabolized and/or excreted through the kidneys 10,29. Lower doses and/or modified dosing intervals are often necessary until the patient’s renal function returns to baseline.…”

Section: Composition and Practices Of A Collaborative Vod/sos Teammentioning

confidence: 99%

See 1 more Smart Citation

Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome

Mangada

Moffet

Nishitani

et al. 2022

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a well-recognized complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The diagnosis and treatment of VOD/SOS require the involvement of multiple specialists covering a wide range of expertise. Interprofessional team-based medical care is standard practice for patients undergoing HCT and has been shown to improve patient and provider satisfaction, enhance efficiency, and improve patient outcomes, particularly for patients in complex medical situations like those with VOD/SOS post-HCT. Interdisciplinary team-based models focus on the synthesis and harmonization of knowledge and methods from different disciplines to create an integrative approach to patient care that both maximizes the expertise of each involved specialist and encourages thought beyond each specialist’s discipline. Multidisciplinary team members provide additive support and work collaboratively with the core team to provide knowledge from their field. The composition of the interdisciplinary HCT team should center on the needs of the patient and institutional resources and involve the expertise of additional multidisciplinary team members based on clinical needs. This review focuses on interdisciplinary and multidisciplinary team-based care of patients with VOD/SOS post-HCT and provides an example of a collaborative VOD/SOS team that includes transplant physicians, nurses, pharmacists, nutrition/dietary specialists, and intensive care teams.

show abstract

Section: Composition and Practices Of A Collaborative Vod/sos Teammentioning

confidence: 99%

Section: Composition and Practices Of A Collaborative Vod/sos Teammentioning

confidence: 99%

Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome

Mangada

Moffet

Nishitani

et al. 2022

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…Частота встречаемости ВОБ/ССО среди госпитализированных в ОРИТ реципиентов алло-ГСК составила 5 % [27]. По данным многоцентрового исследования [73], посвященного оценке результатов лечения больных ВОБ/ССО в ОРИТ с применением дефибротида, был включен 71 больной с ВОБ/ССО (75 % -после алло-ТГСК, 11 % -после ауто-ТГСК, 14 %после химиотерапии, включая инотузумаб озогамицин и гемтузумаб озогамицин). Частота ВОБ/ССО крайне тяжелого течения составила 69 %, ОДН -68 %, ОПП -24 %, печеночной недостаточности -11 %, печеночной комы -8 %, ИВЛ проводили у 58 % больных, вазопрессорную терапию -у 52 %, заместительную почечную терапию (ЗПТ) -у 49 %.…”

Section: воб печениunclassified

Role of the intensive care in allogeneic hematopoietic stem cell transplantation

Shchekina¹,

Galstyan²,

Drokov³

2022

Gematologiâ i transfuziologiâ

View full text Add to dashboard Cite

Introduction. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often complicated by life-threatening conditions.Aim — an analysis of the life-threatening complications in recipients of allogeneic hematopoietic stem cells (allo-HSCs)Main findings. From 10 to 50 % of allo-HSC recipients need to be admitted to the intensive care unit (ICU) due to the development of life-threatening complications. The reasons for ICU admission are acute respiratory failure, sepsis, graft-versus-host disease, veno-occlusive disease, thrombotic microangiopathy, cytokine release syndrome, engraftment syndrome, etc. Conditioning regimen, donor type, stem cell source, underlying disease state and patient comorbidity are the risk factors associated with development of life-threatening conditions. The main prognostic factors of unfavorable ICU outcomes in allo-HSC recipients are the severity of multiple organ dysfunction and the need for organ support.

show abstract

Costs of matched-sibling, unrelated, and haploidentical hematopoietic cell transplantation and risk factors for greater financial burden — a Brazilian FACT-accredited single-center analysis

et al. 2022

View full text Add to dashboard Cite

Sinusoidal Obstruction Syndrome in Critically Ill Patients in the Era of Defibrotide: A Retrospective Multicenter Study

Cited by 4 publications

References 30 publications

Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome

Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome

Role of the intensive care in allogeneic hematopoietic stem cell transplantation

Costs of matched-sibling, unrelated, and haploidentical hematopoietic cell transplantation and risk factors for greater financial burden — a Brazilian FACT-accredited single-center analysis

Contact Info

Product

Resources

About