Sinusitis: Bench to Bedside☆, ☆☆, ★Current Findings, Future Directions

Kaliner, Michael; Osguthorpe, J. David; Fireman, Philip; Anon, Jack B.; Georgitis, John W.; Davis, Mechery; Naclerio, Robert M.; Kennedy, David W.

doi:10.1016/s0091-6749(97)70041-1

Cited by 211 publications

(246 citation statements)

References 73 publications

(23 reference statements)

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“…It is estimated that 15% of the American population has CRS 8 . This pathology is based on the chronic inflammation of the paranasal sinuses Cacosmia and halitosis 6 (54,5%) 4 (30,7%) *The percentage was calculated based on the total number of patients with CRS in the first column and the total number of patients with CRS and polyps in the second column.…”

Section: Discussionmentioning

confidence: 99%

Eficácia da cirurgia endoscópica nasal nos sintomas da rinossinusite crônica associada ou não à polipose

Bunzen¹,

Campos²,

Leão³

et al. 2006

Rev. Bras. Otorrinolaringol.

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Funct ional endoscopic sinus surgery is the preferred treatment for chronic rhinosinusitis currently. Success on symptoms relief and quality of life improvement are the study leading objectives. Study design: retrospective clinical trial. Methods: Questionnaires were given to the patients referred to Hospital das Clinicas-UFPE to chronic rhinosinusitis (CRS) functional endoscopic sinus intervention during [2003][2004]. Symptoms outcome before and after surgery were compared and analyzed using a five-pointranking scale. Results: Twenty-four pacients answered the questions. Eleven pacientes had CRS and 13 had CRS associated with nasal polypos. Quality of life was restricted by CRS in everyone, with a good improvement in 54,2% cases. All patients could recommend functional endoscopic sinus surgery to someone with same nasal problems and only 3 would not get surgery again. The best symptoms relif results were: nasal obstruction (83,3%), cacosmia/halitosis (80%), hyposmia/anosmia (63,15%), headache (62%). Patients with polyps achieved better symptomatic response than patients with only CRS. Conclusions: The leading simptoms were improved by functional endoscopic sinus surgery but not so much we expect. Allergic rhinits presenting, not using nasal spray, poor ambient control influenced this result. Polyps patient achivied better symptoms outcome and quality of life responses on the most of symptoms than CRS pacients.

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Section: Discussionmentioning

confidence: 99%

Eficácia da cirurgia endoscópica nasal nos sintomas da rinossinusite crônica associada ou não à polipose

Bunzen¹,

Campos²,

Leão³

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…Entre estas células inflamatórias, existe uma predominante presença de eosinófilos 15,16 . Em nossa pesquisa, houve um predomínio linfoplasmocitário o qual estava presente em todos os casos (Figura 2).…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

Estudo histopatológico da estrutura óssea da bolha etmoidal em rinossinusite crônica

Almeida

Sampaio

Andrade

et al. 2003

Rev. Bras. Otorrinolaringol.

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Apesar dos avanços no campo da pesquisa e da clínica, a exata fisiopatologia da rinossinusite crônica ainda permanece desconhecida.Vários estudos têm demonstrado as mais variadas alterações histopatológicas que ocorrem em rinossinusite crônica. A mucosa nasal e dos seios paranasais têm sido o local primário dessas pesquisas, porém muito pouco se conhece sobre as alterações ósseas encontradas nesta doença. OBJETIVO: Descrever as características histopatológicas da estrutura óssea da bolha etmoidal em pacientes com rinossinusite crônica. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram avaliados 19 indivíduos com rinossinusite crônica. Por meio da microscopia de luz, foram analisadas as trabéculas ósseas da bolha etmoidal quanto à extensão do depósito de osteóide, a presença de osteoblastos e osteoclasto na superfície das trabéculas, reabsorção, linhas de aposição e fibrose entre as:trabéculas ósseas. Foi analisada também a lâmina própria quanto ao infiltrado inflamatório e aos elementos celulares. À microscopia eletrônica de varredura analisou-se a morfologia óssea. CONCLUSÃO: À microscopia eletrônica de varredura foi possível observar com mais nitidez as margens das trabéculas ósseas reabsorvidas. Nenhum caso foi considerado normal, mas necrose óssea não foi encontrada. Por meio da microscopia de luz, observou-se: depósitos de osteóide, agrupamentos de osteoblastos, fibrose e remodelação óssea em cerca de 90% dos casos. Apesar da ausência de osteoclastos, a reabsorção óssea esteve presente em cerca de 50% dos casos. Estudos futuros acerca da ação dos mediadores inflamatórios presentes na lâmina própria sobre o osso subjacente poderão esclarecer a fisiopatologia da rinossinusite crônica em nível celular.

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“…Rhinosinusitis is inflammation of the nasal and paranasal sinus mucosa and is associated with mucosal alterations ranging from inflammatory thickening to gross nasal polyp formation [1]. Aspergillus spp.…”

Section: Introductionmentioning

confidence: 99%

Fungal Rhinosinusitis: Report of uncommon Aspergillus species as etiological agents

Nagarajan¹,

Premamalini²,

Kindo³

et al. 2014

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We hereby report three cases of fungal sinusitis caused by uncommon Aspergillus such as A. versicolor and A. sydowii. Case 1 was a 40-year-old female came with complaints of nasal block and nasal discharge for past one and a half years with history of previous nasal surgery. Her computed tomography (CT) scan of paranasal sinus (PNS) showed bilateral ethmoidal sinusitis. Case 2 was a 43-year-old male known asthmatic presented with complaints of nasal block for last five years, was diagnosed to have bilateral sinonasal polyposis by anterior rhinoscopy. Case 3 was a 17-year-old female known asthmatic presented with headache, nasal discharge and frequent sneezing for last six months. Her CT PNS showed left side deviated nasal septum with left side pan sinusitis along with right frontal sinusitis. All the three patients underwent functional endoscopic sinus surgery (FESS). The material was sent to the microbiology laboratory for fungal culture and potassium hydroxide mount. Speciation by slide culture was not conclusive. Hence, molecular methods were opted for speciation. Conclusion: Reporting of these cases will ensure awareness among the microbiologists about the not so common Aspergilli as a cause of fungal sinusitis. The need of molecular methods for speciation has also been emphasized here as it is difficult to speciate these Aspergilli using routine conventional methods. IJCRI publishes

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Sinusitis: Bench to Bedside☆, ☆☆, ★Current Findings, Future Directions

Cited by 211 publications

References 73 publications

Eficácia da cirurgia endoscópica nasal nos sintomas da rinossinusite crônica associada ou não à polipose

Eficácia da cirurgia endoscópica nasal nos sintomas da rinossinusite crônica associada ou não à polipose

Estudo histopatológico da estrutura óssea da bolha etmoidal em rinossinusite crônica

Fungal Rhinosinusitis: Report of uncommon Aspergillus species as etiological agents

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