Sinusitis and frontal brain abscess in a diabetic patient caused by the basidiomycete <i>Schizophyllum commune</i>: case report and review of the literature

Hoenigl, Martin; Aspeck, E; Valentin, Thomas; Heiling, Bettina; Seeber, Katharina; Krause, Robert; Stammberger, Heinz R.; Beham, Alfred; Buzina, Walter

doi:10.1111/myc.12040

Cited by 30 publications

(20 citation statements)

References 33 publications

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“…Reports of other clinical manifestations, however, are rare. In the last 15 years, only two cases of brain involvement have been reported, the first one in an immunocompro mised and the second one in an immunocompetent patient [14,17]. There is a single report of eye infection and the ulceration of the palate [18,19], but there are no reports of skin infections, as in our case.…”

Section: Discussionmentioning

confidence: 83%

“…From 2012 to 2014, there were three cases also describing lung involvement-two of them are cases of allergic bronchopulmonary mycosis and one case of a fatal empyema thoracis in an older patient suffering from chronic obstructive lung disease and a history of pulmonary tuberculosis [10,11]. Besides bronchopulmonary involvement, sinusitis is also a commonly encountered clinical manifestation-there are reports of sinusitis where the infection is also affecting the nearby tissue, the orbit or the brain [3,[12][13][14][15][16]. Reports of other clinical manifestations, however, are rare.…”

Section: Discussionmentioning

confidence: 96%

“…It is found as a pathogenic agent worldwide, but it is most frequently encountered in Far Eastern countries, almost half (46 %) of the cases come from Japan [3]. It has mostly been described as a causative agent of allergic sinusitis and allergic bronchopulmonary mycosis [4][5][6][7]. Chrowdhary et al [3] described 71 cases of S. commune infections from different parts of the world; 45 (63 %) of them had bronchopulmonary involvement-with allergic bronchopulmonary mycosis as the most frequent clinical manifestation-and 22 (31 %) had cases of sinusitis.…”

Section: Discussionmentioning

confidence: 99%

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First report of otitis externa caused by Schizophyllum commune and review of the literature

Matos

Tomazin

Battelino

2016

Wien Klin Wochenschr

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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First report of otitis externa caused by Schizophyllum commune and review of the literature

Matos

Tomazin

Battelino

2016

Wien Klin Wochenschr

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“…The most recent reviews of infections by S. commune were by Buzina et al (33), who reported 16 published cases, and Chowdhary et al (13), who reported 71 cases. More recently, 15 additional cases have been reported (14,15,17,19,(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59). Here, we studied 23 isolates of Schizophyllum from different clinical specimens, and although histopathological evidence for the corresponding infections is not available, this number of isolates from a single country reinforces the growing importance of Schizophyllum in the clinical setting.…”

Section: Discussionmentioning

confidence: 94%

“…In recent years, S. commune has become clinically relevant as an etiological agent of respiratory infections in humans (10)(11)(12)(13)(14)(15). However, it has been reported to be an etiological agent of other types of infections and conditions, such as a brain abscess (16,17), meningitis (18), an eye infection (19), palate ulceration (20), and onychomycosis (21). Infections have also been reported in other mammals (22)(23)(24) and in both immunocompromised and immunocompetent individuals (25,26).…”

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confidence: 99%

Schizophyllum radiatum, an Emerging Fungus from Human Respiratory Tract

et al. 2016

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Schizophyllum is an important genus of basidiomycetes that, apart from being of genetic and biotechnological interest, is also reported to be a plant and animal pathogen. Schizophyllum commune is the best-known species and the only one reported from clinical specimens thus far, being recovered mainly from the respiratory tract. The aim of this study was to determine the species diversity of 23 clinical isolates of Schizophyllum from the United States using multilocus phylogenetic analysis and their in vitro susceptibilities to six drugs. The markers used for sequencing were the internal transcribed spacer (ITS), a portion of the nuclear large subunit (LSU) of ribosomal DNA, the RNA polymerase II second-largest subunit (RPB2), and the translation elongation factor 1␣ (EF-1␣) gene. The analyses revealed that 22 of the clinical isolates were in the Schizophyllum radiatum clade with high support values and 1 isolate was in the S. commune clade. This is the first report of this species in clinical samples. The two species mentioned above showed very similar morphological features in culture (i.e., white, cottony, unsporulated colonies composed of hyphae with clamp connections), making morphological discrimination between the two impossible. An epitype is designed for S. radiatum, and its sequences have been deposited in GenBank. The antifungal that showed the greatest in vitro activity against the strains tested was shown to be amphotericin B. In general, the strains of S. radiatum showed higher MICs than S. commune. S chizophyllum (Schizophyllaceae, Agaricales) comprises one of the most commonly found mushrooms on the planet (1). The most common species of the genus is Schizophyllum commune, a ubiquitous fungus well-known as a wood decay organism able to cause white rot (1, 2) but also by its biotechnological applications (3). It has been used as an ethanol producer (4), and some of its metabolites have anticancer (5) and antimicrobial (6, 7) properties. It also has been studied for many years as a model for understanding mating interactions (8, 9). In recent years, S. commune has become clinically relevant as an etiological agent of respiratory infections in humans (10-15). However, it has been reported to be an etiological agent of other types of infections and conditions, such as a brain abscess (16, 17), meningitis (18), an eye infection (19), palate ulceration (20), and onychomycosis (21). Infections have also been reported in other mammals (22-24) and in both immunocompromised and immunocompetent individuals (25,26).The most effective treatment options for infections by S. commune are yet to be determined, although various treatment modalities have been used (14,(25)(26)(27)(28)(29). Most susceptibility patterns for these fungi are restricted to individual cases; however, studies by Gonzalez et al. (30) and Chowdhary et al. (31) with 5 and 26 strains, respectively, indicated that amphotericin B (AMB), itraconazole (ITC), and voriconazole (VRC) had good in vitro activity against the isolates tested, while elev...

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Cladosporium spp., Fusarium spp., Bipolaris spp., Schizophyllum commune, and Scedosporium apiospermum

Kantarcıoğlu

2019

Fungal Infections of the Central Nervous System

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Sinusitis and frontal brain abscess in a diabetic patient caused by the basidiomycete Schizophyllum commune: case report and review of the literature

Cited by 30 publications

References 33 publications

First report of otitis externa caused by Schizophyllum commune and review of the literature

First report of otitis externa caused by Schizophyllum commune and review of the literature

Schizophyllum radiatum, an Emerging Fungus from Human Respiratory Tract

Cladosporium spp., Fusarium spp., Bipolaris spp., Schizophyllum commune, and Scedosporium apiospermum

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