Sinus Tissue Pharmacokinetics After Oral Administration of Amoxicillin/Clavulanic Acid

Dinis, Paulo Borges; Monteiro, Maria Conceição; Martins, Maria Luz; Silva, Nuno; Gomes, Alexandra

doi:10.1097/00005537-200006000-00030

Cited by 25 publications

(8 citation statements)

References 22 publications

(33 reference statements)

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“…In fact, there were many reports on the tissue concentration of antimicrobial and anticancer drugs in the human nasal and paranasal region [5–7]. Histamine is an important chemical mediator in allergic rhinitis and plays an important role in eliciting the nasal symptoms of the disorder [8].…”

Section: Discussionmentioning

confidence: 99%

Concentrations of H1-Receptor Antagonist in the Human Nasal Mucosa

Takasaki

Enatsu

Kumagami

et al. 2009

International Journal of Otolaryngology

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Aims. To measure blood and tissue concentrations of the H1-receptor antagonist, bepotastine besilate (BB). Methods. Participants included 14 men and six women, whose age ranged from 13 to 76 years, with chronic rhinosinusitis, who underwent endoscopic sinus surgery at our university hospital. Among them, 10 participants had allergic rhinitis (AR) (Group I), and others did not have AR (Group II). Nasal mucosa and blood were collected 55 to 130 minutes after oral administration of BB 10 mg. Concentrations of the agent in the serum and nasal mucosa were measured by high-performance liquid chromatography. Results. Concentrations of BB of the serum in Group I and II were 98 ± 32 ng/mL and 112 ± 39 ng/mL. Those of the nasal mucosa tissue in Groups I and II were 101 ± 36 ng/g and 132 ± 44 ng/g. There was no significant difference in the values of concentration of BB between the serum and the nasal mucosa in either Group I or II (P = .757 and P = .2662, resp., Paired t-test). Conclusion. This preliminary study is considered the first report on the concentration of H1-receptor antagonists in nasal mucosa. The prompt absorption and transition to the nasal mucosa of BB seems to have an effect on allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Concentrations of H1-Receptor Antagonist in the Human Nasal Mucosa

Takasaki

Enatsu

Kumagami

et al. 2009

International Journal of Otolaryngology

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“…Given the absence of direct evidence for antibiotic prophylaxis before SES, inclusion criteria were expanded to incorporate papers of all levels of evidence, including expert opinion. Publications providing indirect evidence for appropriate prophylactic antibiotic regimens (e.g., studies testing antibiotic sensitivity in sinusitis patients) were also included ( Table ) . Studies that merely reported use of perioperative antibiotics for SES or associated postsurgical complications were excluded, as these reports neither provided rationale for antibiotic selection nor sought to specifically justify use of one antibiotic over another .…”

Section: Search Outcomementioning

confidence: 99%

“…Publications providing indirect evidence for appropriate prophylactic antibiotic regimens (e.g., studies testing antibiotic sensitivity in sinusitis patients) were also included ( Table 2). 5,8,[17][18][19][20][21][22][23][24][25][26][27][30][31][32][33][34][35] Studies that merely reported use of perioperative antibiotics for SES or associated postsurgical complications were excluded, as these reports neither provided rationale for antibiotic selection nor sought to specifically justify use of one antibiotic over another. [1][2][3][4]6,7,[10][11][12]14,16,[36][37][38]…”

Section: Search Outcomementioning

confidence: 99%

“…26 Mixed results appear in the literature regarding achievable concentrations of CA in the mucosa of the maxillary sinus. 31,33 One study found favorable tissue concentrations of both AMX and CA 2 to 6 hours after oral AMC administration. 31 In another study, mucosal CA concentrations varied widely among individuals, with undetectable tissue concentrations recorded at almost half of evaluated sinonasal sites.…”

Section: Antibioticmentioning

confidence: 99%

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Rational Prophylactic Antibiotic Selection for Sinus Elevation Surgery

Akers

Hill

Kawaguchi

2019

Clin Adv Periodontics

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Focused Clinical Question For a generally healthy patient with no risk indicators for postoperative infection, what is the most appropriate perioperative antibiotic regimen for sinus elevation surgery in terms of reducing postoperative infection risk and minimizing untoward effects? Clinical Scenario A 38‐year‐old female patient in good general and periodontal health presents missing tooth #14 (Fig. ). She reports no systemic conditions, no history of sinusitis, and no allergies. Medications include acetaminophen and ibuprofen as needed for pain. The patient's dentition is minimally restored, with no active caries. Cone‐beam computed tomography reveals a clear, pneumatized left maxillary sinus and inadequate bone volume to support dental implant placement (Fig. ). No septa or pathologic lesions are present, the ostium appears patent, and no thickening of the Schneiderian membrane is appreciable. The patient states that she wants to replace her missing molar without restoring adjacent teeth (Figs. and ). Baseline clinical appearance (example sinus elevation case). The patient is a healthy 38‐year‐old female missing tooth #14. Inadequate bone volume is present for dental implant placement due to pneumatization of the left maxillary sinus. Preoperative cone‐beam computed tomography images. 2a Sagittal view. 2b Coronal view. Cone‐beam computed tomography images at postoperative month 6. 3a Sagittal view. 3b Coronal view. Definitive implant‐supported restoration, tooth #14.

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“…If the patient dose not get better in 48–72 hours, then antibiotic should be changed to amoxicillin with clavulanic acid. Three to four weeks of amoxicillin with clavulanic acid is a first-line choice for CRS or those children with acute exacerbation of CRS because of adequate penetration of the sinus mucosa and efficacy against S. aureus and anaerobes [19]. Antibiotic choice is largely guided by patient tolerance.…”

Section: Treatmentmentioning

confidence: 99%

Chronic Rhinosinusitis in Children

Ramadan

2012

International Journal of Pediatrics

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Rhinosinusitis is a very common disease worldwide and specifically in the US population. It is a common disease in children but may be underdiagnosed. Several reasons may account to the disease being missed in children. The symptoms in children are limited and can be very similar to the common cold or allergic symptoms. Cough and nasal discharge may be the only symptoms present in children. A high index of suspicion is necessary to make the diagnosis of rhinosinusitis in these children. The majority of those children are treated medically. Only a few number will require surgical intervention when medical treatment fails. Complications of rhinosinusitis, even though rare, can carry a high morbidity and mortality rate.

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Sinus Tissue Pharmacokinetics After Oral Administration of Amoxicillin/Clavulanic Acid

Cited by 25 publications

References 22 publications

Concentrations of H1-Receptor Antagonist in the Human Nasal Mucosa

Concentrations of H1-Receptor Antagonist in the Human Nasal Mucosa

Rational Prophylactic Antibiotic Selection for Sinus Elevation Surgery

Chronic Rhinosinusitis in Children

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