Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): a rare case of subglottic narrowing

Courteney-Harris, R. G.; Goddard, Martin

doi:10.1017/s0022215100118638

Cited by 15 publications

(8 citation statements)

References 3 publications

(3 reference statements)

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“…Patients may have a destructive disease, with osseous, cartilaginous, and/or soft tissue erosion and destruction with extension into ad-jacent anatomic compartments. 38 • 55 On the basis of the clinical course of the disease, patients can be subdivided into 1) those who undergo a complete and spontaneous remission; 2) those with a chronic course, marked by remission and exacerbations; 3) those with persistent but stable disease; 4) those with progressive disease; and 5) patients who die with disseminated nodal disease and/or involvement of many extranodal organ systems and/or involvement of unusual sites (kidney, lower respiratory tract). 6 However, the role of RD disease in the cause of death is difficult to ascertain.…”

Section: Course Of Disease and Treatmentmentioning

confidence: 99%

“…65 Aggressive systemic therapy would appear to have no place in the treatment of localized disease. Conversely, in those patients with extensive, recurrent, or progressive disease, which compromises organ function, radical surgical procedures such as craniotomy, 21 partial maxillectomy, 55 or tracheostomy 38 may be needed. Endoscopie surgery is the optimal treatment for nasal involvement and can ensure an improved airway after operation.…”

Section: Course Of Disease and Treatmentmentioning

confidence: 99%

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Review of Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) of Head and Neck

Carbone¹,

Passannante²,

Gloghini³

et al. 1999

Ann Otol Rhinol Laryngol

104

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The entity known as sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease (RD disease), is an uncommon benign proliferation of hematopoietic and fibrous tissue that often presents in the head and neck region. Its initial manifestations most often include a roughly symmetric, painless, bilateral cervical adenopathy, although extranodal disease may develop in a minority of patients. The key histologic feature of SHML is the presence of various numbers of large, pale histiocytic cells that contain within their cellular borders apparently engulfed lymphocytes ("emperipolesis"); these distinctive large, pale cells - RD cells - are S-100 protein-positive by immunostaining and so differ from ordinary histiocytes. Despite its sometimes impressive clinical presentation, SHML is a benign and self-limited disease, whose treatment is aimed largely at controlling its local manifestations (most often by surgical therapy). The microscopic differential diagnosis, particularly in extranodal disease, is at times challenging and can include Langerhans' cell histiocytosis, Hodgkin's disease, non-Hodgkin's lymphoma, metastatic carcinoma, and metastatic malignant melanoma.

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Section: Course Of Disease and Treatmentmentioning

confidence: 99%

Section: Course Of Disease and Treatmentmentioning

confidence: 99%

Review of Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) of Head and Neck

Carbone¹,

Passannante²,

Gloghini³

et al. 1999

Ann Otol Rhinol Laryngol

104

View full text Add to dashboard Cite

show abstract

“…El uso de corticoides sistémicos, quimioterapia, radioterapia o cirugía ha sido reportado en el caso de lesiones que podrían producir compromiso orgánico grave 21 . En el caso de lesiones que comprometen las vías respiratorias, las opciones de tratamiento han incluido la resección quirúrgica o con láser de CO 2 de las lesiones, uso de corticoides sistémicos o isotretinoína [22][23][24][25] . Sin embargo, la resección de las lesiones presenta una alta tasa de recurrencias 16 .…”

Section: Discussionunclassified

Enfermedad de Rosai-Dorfman con compromiso laríngeo: A propósito de un caso

Pablo

José

et al. 2018

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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La enfermedad de Rosai-Dorfman (ERD) o histiocitosis sinusal con linfadenopatía masiva es una enfermedad infrecuente, de etiología desconocida caracterizada por linfadenopatías cervicales masivas bilaterales. El compromiso extraganglionar puede ocurrir en diferentes sitios, incluida la vía aérea, en la cual la localización nasosinusal es la más frecuente, pero puede comprometer también otros sitios de la vía aérea superior. Dentro de éstos, el compromiso laríngeo es muy poco frecuente. Se presenta el caso de una paciente de 82 años con antecedentes de ERD localizada en los ganglios linfáticos cervicales en remisión espontánea, que desarrolló posteriormente una obstrucción subaguda de las vías respiratorias. La tomografía computarizada y la nasofaringolaringoscopía mostraron lesiones subglóticas que obstruían severamente las vías respiratorias. Se realizó una traqueostomía de emergencia y biopsia de las lesiones, confirmando el diagnóstico de ERD extranodal. Palabras clave: Enfermedad de Rosai-Dorfman; histiocitosis sinusal con linfadenopatía; estenosis laríngea; obstrucción de la vía aérea.

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“…Extranodal rdd of the larynx has been documented in the literature [8][9][10][11][12][13][14][15][16][17][18] . In these cases, treatment was initiated because of symptoms such as stridor, dysphagia, dysphonia, and dyspnea because of a laryngeal lesion.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease

et al. 2011

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Rosai–Dorfman disease is a rare lymphoproliferative disorder that can have nodal and extranodal manifestations. In the absence of established guidelines for the management of this condition, various therapeutic modalities are used, including radiotherapy. Radiation dosages and fractionation schedules have not been reported in all instances. We present a case in which glottic and subglottic Rosai–Dorfman lesions causing airway obstruction in a frail steroid-refractory patient were put into complete remission using radiotherapy. The lesions responded transiently to a course of prednisone, but responded completely to external-beam radiation, with minimal side effects to the patient.

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Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): a rare case of subglottic narrowing

Cited by 15 publications

References 3 publications

Review of Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) of Head and Neck

Review of Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) of Head and Neck

Enfermedad de Rosai-Dorfman con compromiso laríngeo: A propósito de un caso

Radiotherapy for Steroid-Resistant Laryngeal Rosai–Dorfman Disease

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