Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers

Kimura, Hirokazu; Konno, Satoshi; Nakamaru, Yuji; Makita, Hironi; Taniguchi, Natsuko; Shimizu, Kaoruko; Suzuki, Masaru; Ono, Junya; Izuhara, Kenji; Nishimura, Masaharu

doi:10.1513/annalsats.201606-463oc

Cited by 49 publications

(49 citation statements)

References 36 publications

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“…The details of the materials and methods used in this study were described in our previous report and can be found in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…The Hokkaido Severe Asthma Cohort Study (the Hokkaido‐based Investigative Cohort Analysis for Refractory Asthma [Hi‐CARAT]) is a multicenter observational cohort study, which primarily aims to characterize subjects with severe asthma, including those who smoke. The details of this study protocol have been reported previously . Patients with severe asthma were enrolled at Hokkaido University Hospital and its 29 affiliated hospitals and clinics between February 2010 and September 2012.…”

Section: Methodsmentioning

confidence: 99%

“…The diagnosis of severe asthma required one or both major criteria and 2 minor criteria. Patients who were well‐controlled under the current medications were asked if within 1 year they experienced episodic deterioration of symptoms, urgent care visits, and rescue use of short‐acting bronchodilators when the dose of the current medication was reduced …”

Section: Methodsmentioning

confidence: 99%

“…In this study, using the obtained at the subjects’ study entry point for the Hokkaido Severe Asthma Cohort Study, we previously reported the clinical characteristics of such subjects, with particular focus upon upper and lower airway inflammation and airflow limitation in relation to smoking status . We recently finished the 3‐year follow‐up, in which we yearly made repeated measurements of clinical and biological parameters.…”

Section: Introductionmentioning

confidence: 99%

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Prospective predictors of exacerbation status in severe asthma over a 3‐year follow‐up

Kimura

Konno

Makita

et al. 2018

Clin Experimental Allergy

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“…The details of the materials and methods used in this study were described in our previous report and can be found in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prospective predictors of exacerbation status in severe asthma over a 3‐year follow‐up

Kimura

Konno

Makita

et al. 2018

Clin Experimental Allergy

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“…Details of the pulmonary function tests are described in the online supplement and in our previous report [6, 7]. …”

Section: Methodsmentioning

confidence: 99%

Clinical Course of Histologically Proven Multifocal Micronodular Pneumocyte Hyperplasia in Tuberous Sclerosis Complex: A Case Series and Comparison with Lymphangiomyomatosis

Konno

Shigemura

Ogi³

et al. 2018

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Background: Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of tuberous sclerosis complex (TSC). Because of its rarity, no previous study has described the detailed clinical course of this disease. Objectives: This study aimed to clarify the longitudinal clinical characteristics of subjects with MMPH. Methods: Nine patients with MMPH diagnosed at Hokkaido University Hospital were retrospectively analyzed. Changes in computed tomography findings and pulmonary function were compared during the follow-up period. Serum levels of KL-6, surfactant protein (SP)-A, and SP-D were measured to clarify their potentials as blood biomarkers of the disease. Fourteen cases of lymphangiomyomatosis (LAM) were also included to compare their clinical characteristics with those of subjects with MMPH. Results: Of the 9 patients, 7 were female and 2 were male. The median age at diagnosis was 43 years (range, 19–56), and all cases were diagnosed following incidental abnormal radiographic findings. During the follow-up, 1 patient died of lung cancer, but others were radiographically stable and had stable pulmonary function. Serum levels of SP-A in 5 patients (mean, 146.4 ng/mL) and SP-D in 6 patients (mean, 337.3 ng/mL) were elevated in subjects with MMPH, whereas KL-6 levels were within the reference range (mean, 230 U/mL) in all patients. Levels of SP-A and SP-D were significantly higher in subjects with MMPH than those with LAM (p < 0.05). Conclusions: Radiographic findings and pulmonary function were stable in all cases of MMPH. Serum SP-A and SP-D, but not KL-6, may be useful markers for suspicion of the presence of MMPH in patients with TSC.

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Volumetric assessment of paranasal sinus opacification on computed tomography can be automated using a convolutional neural network

Humphries

Centeno

Notary

et al. 2020

Int Forum Allergy Rhinol

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Background Computed tomography (CT) plays a key role in evaluation of paranasal sinus inflammation, but improved, and standardized, objective assessment is needed. Computerized volumetric analysis has benefits over visual scoring, but typically relies on manual image segmentation, which is difficult and time‐consuming, limiting practical applicability. We hypothesized that a convolutional neural network (CNN) algorithm could perform automatic, volumetric segmentation of the paranasal sinuses on CT, enabling efficient, objective measurement of sinus opacification. In this study we performed initial clinical testing of a CNN for fully automatic quantitation of paranasal sinus opacification in the diagnostic workup of patients with chronic upper and lower airway disease. Methods Sinus CT scans were collected on 690 patients who underwent imaging as part of multidisciplinary clinical workup at a tertiary care respiratory hospital between April 2016 and November 2017. A CNN was trained to perform automatic segmentation using a subset of CTs (n = 180) that were segmented manually. A nonoverlapping set (n = 510) was used for testing. CNN opacification scores were compared with Lund‐MacKay (LM) visual scores, pulmonary function test results, and other clinical variables using Spearman correlation and linear regression. Results CNN scores were correlated with LM scores (rho = 0.82, p < 0.001) and with forced expiratory volume in 1 second (FEV1) percent predicted (rho = −0.21, p < 0.001), FEV1/forced vital capacity ratio (rho = −0.27, p < 0.001), immunoglobulin E (rho = 0.20, p < 0.001), eosinophil count (rho = 0.28, p < 0.001), and exhaled nitric oxide (rho = 0.40, p < 0.001). Conclusion Segmentation of the paranasal sinuses on CT can be automated using a CNN, providing truly objective, volumetric quantitation of sinonasal inflammation.

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Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers

Cited by 49 publications

References 36 publications

Prospective predictors of exacerbation status in severe asthma over a 3‐year follow‐up

Prospective predictors of exacerbation status in severe asthma over a 3‐year follow‐up

Clinical Course of Histologically Proven Multifocal Micronodular Pneumocyte Hyperplasia in Tuberous Sclerosis Complex: A Case Series and Comparison with Lymphangiomyomatosis

Volumetric assessment of paranasal sinus opacification on computed tomography can be automated using a convolutional neural network

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