Sinus bradycardia during hypothermia in comatose survivors of out-of-hospital cardiac arrest – A new early marker of favorable outcome?

Thomsen, Jakob Hartvig; Hassager, Christian; Bro-Jeppesen, John; Søholm, Helle; Nielsen, Niklas; Wanscher, Michael; Køber, Lars; Pehrson, Steen; Kjærgaard, Jesper

doi:10.1016/j.resuscitation.2014.12.031

Cited by 65 publications

(34 citation statements)

References 20 publications

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“…They proposed that sinus bradycardia should be the early marker of favorable outcome in comatose survivors of OHCA. 1 In connection to this, we would like to share our previous results for a pilot retrospective study of 18 comatose survivors of in-hospital cardiac arrest. Our study included mixed etiology of cardiac arrest.…”

Section: Should the Heart Rate Including The Heart Rate Variability Bmentioning

confidence: 91%

Should the heart rate including the heart rate variability be important prognostigators in cardiac arrest?

2016

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Section: Should the Heart Rate Including The Heart Rate Variability Bmentioning

confidence: 91%

Should the heart rate including the heart rate variability be important prognostigators in cardiac arrest?

2016

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“…Sinus bradycardia is also commonly presented during sustainment stage. Heart rate usually lowers less than 50 beats per minute without any effect to hemodynamic status, therefore, requires no treatment [109].…”

Section: Shivering and Common Physiologic Responsementioning

confidence: 99%

Targeted Temperature Management in Traumatic Brain Injury

Muengtaweepongsa¹,

Yodwisithsak²

2018

Traumatic Brain Injury - Pathobiology, Advanced Diagnostics and Acute Management

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Traumatic brain injury (TBI) remains an important health problem worldwide. Patho physiology of TBI has been intensively investigated. Many novel theories related with pathophysiology of TBI have been regularly proposed. Targeted temperature management (TTM), previously known as therapeutic hypothermia, has a well-established benefit for application as neuroprotective therapy and intracranial pressure (ICP) control. With the novel automatic feedback machine, application of TTM in clinical practice becomes much feasible and safe. Many preclinical trials of TTM in models with TBI demonstrated useful ness in multiple aspects. The successful story of TTM in patients with restore of spontaneous circulation (ROSC) after cardiac arrest is a good example for bench to bedside. In the past decade, many clinical trials of TTM in patients with TBI have been conducted with the hope to be another successful study.

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“…Elevated peripheral vascular resistance during induction phase of TTM is usually transient and takes no effect to systemic blood pressure[70]. Sinus bradycardia with heart rate less than 50 beats per minute occurs in almost 50% of patients with PCAS during maintenance phase[71]. Nevertheless, this bradycardia should also indicate an intact physiologic response, does not require any treatment due to no hemodynamic effect and may predict good prognosis[72].…”

Section: Shivering and Common Physiologic Responsementioning

confidence: 99%

Targeted temperature management in neurological intensive care unit

Muengtaweepongsa¹,

Srivilaithon²

2017

WJM

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Targeted temperature management (TTM) shows the most promising neuroprotective therapy against hypoxic/ischemic encephalopathy (HIE). In addition, TTM is also useful for treatment of elevated intracranial pressure (ICP). HIE and elevated ICP are common catastrophic conditions in patients admitted in Neurologic intensive care unit (ICU). The most common cause of HIE is cardiac arrest. Randomized control trials demonstrate clinical benefits of TTM in patients with post-cardiac arrest. Although clinical benefit of ICP control by TTM in some specific critical condition, for an example in traumatic brain injury, is still controversial, efficacy of ICP control by TTM is confirmed by both in vivo and in vitro studies. Several methods of TTM have been reported in the literature. TTM can apply to various clinical conditions associated with hypoxic/ischemic brain injury and elevated ICP in Neurologic ICU.

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Sinus bradycardia during hypothermia in comatose survivors of out-of-hospital cardiac arrest – A new early marker of favorable outcome?

Cited by 65 publications

References 20 publications

Should the heart rate including the heart rate variability be important prognostigators in cardiac arrest?

Should the heart rate including the heart rate variability be important prognostigators in cardiac arrest?

Targeted Temperature Management in Traumatic Brain Injury

Targeted temperature management in neurological intensive care unit

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