Sinus Bacteriology in Patients with Cystic Fibrosis or Primary Ciliary Dyskinesia: A Systematic Review

Me, Møller; Mc, Alanin; Grønhøj, Christian; Aanæs, Kasper; Høiby, Niels; Buchwald, Christian von

doi:10.2500/ajra.2017.31.4461

Cited by 23 publications

(23 citation statements)

References 75 publications

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“…Moreover, a detection rate of 13% was reported for P. aeruginosa by Deschaght et al in 2010 from Belgium in a study conducted on 397 adult and pediatric CF patients (22). The molecular results in our study showed a high rate of colonization with Pseu- nosa was one of the most commonly detected bacteria isolated from noses and sinuses of CF patients (23). This difference could be attributed to various factors, including differences in the frequency of Pseudomonas spp.…”

Section: Discussionsupporting

confidence: 56%

Molecular Identification of Gram-Negative Bacteria in Respiratory Samples of Cystic Fibrosis Patients from a Children Referral Hospital in Tehran

Azimi

Ghanaiee

Shirdust

et al. 2019

Arch Pediatr Infect Dis

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Background: Gram-negative bacteria are a major cause of pulmonary infection in patients with cystic fibrosis (CF). Objectives: The study aimed to conduct the molecular identification of Gram-negative bacterial flora causing pulmonary infection in children with CF. Methods: In this study, sputum samples were taken from 64 CF children undergoing treatment as outpatients or inpatients at a referral children's hospital in Tehran. The PCR technique was used to detect the presence of Gram-negative bacteria, namely Pseudomonas spp., Acinetobacter baumannii, Stenotrophomonas maltophilia, and Burkholderia cepacia. Results: All samples were positive for 16srRNA. Pseudomonas spp. and A. baumannii were detected in 47% and 14% of the studied samples, respectively. Co-colonization by Pseudomonas spp. and A. baumannii was observed in three (5%) samples. Conclusions: According to this survey, Pseudomonas spp. were the most prevalent Gram-negative bacteria isolated from CF patients with pulmonary infection by molecular assays.

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Section: Discussionsupporting

confidence: 56%

Molecular Identification of Gram-Negative Bacteria in Respiratory Samples of Cystic Fibrosis Patients from a Children Referral Hospital in Tehran

Azimi

Ghanaiee

Shirdust

et al. 2019

Arch Pediatr Infect Dis

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“…For this study, the following were the bacterial species we considered clinically “relevant”: P. aeruginosa , Staphylococcus aureus , Achromobacter xylosoxidans , Burkholderia cepacia complex , E. coli , Enterococcus , Streptococcus pneumoniae , Haemophilus influenzae , Proteus mirabilis , Serratia marcescens . Normal flora was defined based on published evidence available, including Neisseria spp., Corynebacterium spp., alpha‐hemolytic streptococci, Rothia spp., coagulase‐negative staphylococci, and non‐hemolytic streptococci, which are commonly considered part of the human nasopharyngeal microbiome …”

Section: Methodsmentioning

confidence: 99%

“…Normal flora was defined based on published evidence available, including Neisseria spp., Corynebacterium spp., alpha-hemolytic streptococci, Rothia spp., coagulase-negative staphylococci, and non-hemolytic streptococci, which are commonly considered part of the human nasopharyngeal microbiome. [25][26][27] For all the patients needing a previously scheduled (graft surveillance based on local protocol) flexible bronchoscopy via the nasal route on the date of baseline visit, additional tests were performed:…”

Section: Nasal Lavagementioning

confidence: 99%

The burden of sinus disease in cystic fibrosis lung transplant recipients

Morlacchi

Greer

Tudorache

et al. 2018

Transplant Infectious Dis

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“…Retention and survival of bacteria on toothbrushes after brushing represent a possible cause of re-contamination of the mouth. Several studies [17,21] have shown that prolonged use of the toothbrush facilitates contamination by various microorganisms such as species of Streptococcus, Staphylococcus, Lactobacillus, Pseudomonas, Klebsiella and Candida, and by Escherichia coli. In CF children, P. aeruginosa and S. aureus nasopharyngeal carriage is up to 14%.…”

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confidence: 99%

Toothbrushes may convey bacteria to the cystic fibrosis lower airways

Mantovani

Sandri

Boaretti

et al. 2019

Journal of Oral Microbiology

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Recent findings indicate that the oral cavity acts as a bacterial reservoir and might contribute to the transmission of bacteria to the lower airways. Control of a potentially pathogenic microbiota might contribute to prevent the establishment of chronic infection in cystic fibrosis. We evaluated the presence of CF microorganisms in saliva and toothbrushes of CF patients and verify their possible transmission to lower airways. Methods: We assessed the presence of P. aeruginosa, S. aureus, S. maltophilia, A. xylosoxidans, S. marcescens, and yeasts in saliva, toothbrushes and sputum of 38 CF patients and assessed the clonal identity of the strains occurring contemporary in multiple sites by PFGE. Results: At least one of the investigated species was isolated from 60 saliva samples and 23 toothbrushes. S. aureus was the most abundant species, followed by Candida spp. 31 patients contemporary had the same species in sputum and saliva/toothbrush: in most cases, clonal identity of the strains among the different sites was confirmed. Conclusion: Toothbrushes may be sources of oral contamination and might act as reservoirs favoring transmission of potentially pathogenic microorganisms from the environment to the oral cavity and eventually to the LAW. Oral hygiene and toothbrush care are important strategies to prevent CF lung infections.

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Sinus Bacteriology in Patients with Cystic Fibrosis or Primary Ciliary Dyskinesia: A Systematic Review

Abstract: Background: A correlation exists between the microbial flora of the upper and lower airways in patients with cystic fibrosis (CF)

Cited by 23 publications

References 75 publications

Molecular Identification of Gram-Negative Bacteria in Respiratory Samples of Cystic Fibrosis Patients from a Children Referral Hospital in Tehran

Molecular Identification of Gram-Negative Bacteria in Respiratory Samples of Cystic Fibrosis Patients from a Children Referral Hospital in Tehran

The burden of sinus disease in cystic fibrosis lung transplant recipients

Toothbrushes may convey bacteria to the cystic fibrosis lower airways

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