Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice

Izolan, Lucas dos Reis; Silva, Douglas Marques da; Oliveira, Helena Beatriz Larrosa; Salomón, Janaína Lucas de Oliveira; Peruzzi, Caroline Portela; García, Solange Cristina; Dallegrave, Eliane; Zanotto, Caroline; Elisabetsky, Elaine; Gonçalves, Carlos Alberto; Arbo, Marcelo Dutra; Konrath, Eduardo Luis; Leal, Mirna Bainy

doi:10.1007/s11064-021-03237-w

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…In this study, Passiflora extract, especially in higher doses, causes an increase in GABA levels in the cerebellum and spinal cord, structures particularly involved in motor functions. Dos Reis Izolan et al [6] found that a commercial standardized dry extract (Sintocalmy®, Aché Laboratories, Brazil), at the dose of 50 and 100 mg i.p. reduced naloxoneinduced jumping in mice, a morphine withdrawal model without reducing exploratory activity.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the long-term use of the plant in traditional medicine, only a few good quality data of clinical importance are available. According to current knowledge, the passion flower can be considered in the treatment of anxiety, insomnia, menopause, vasomotor symptoms and depression, as well as in the treatment of opioid addiction [4][5][6]. Moreover, the most promising studies concerned the efficacy of the passion flower in the Attention-Deficit Hyperactivity Disorder (ADHD) in children, in the therapy of generalized anxiety disorder and pre-operative anxiety [7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of <i>Passiflora incarnata</i> L. extract on exploratory behaviour and neurotransmitters level in structures involved in motor functions in rats

Blecharz-Klin,

Pyrzanowska,

Piechal

et al. 2024

J Pre Clin Clin Res.

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Introduction andObjective. The genus Passiflora incarnata L. is used in traditional medicine for its analgesic, anxiolytic and sedative purposes, and its flavoursome fruits have long been consumed, especially in North America. The aim of the study is to assess the effect of extract of P. incarnata L. on the motor activity of rats. Materials and Method. Behavioural testing was performed in rats previously exposed to P. incarnata L. extract (30, 100, 300 mg/kg b.w). To explain the neurobiochemical background of behavioural changes, the concentration of neurotransmitters after extract consumption were assayed in CNS structures responsible for motor function using High Performance Liquid Chromatography.Results. The study demonstrated that exposure to the extract resulted in dose dependent modulation of rats behaviour, and altered neurotransmission in major elements of the CNS locomotor system. The changes concerned primarily the cerebellar and spinal dopaminergic and noradrenergic systems. Conclusions. Inhibitory effect of P. incarnata L. extract on the GABAergic pathway has potential as a sedative agent and may be promising alternative to benzodiazepines in controlling anxiety and hyperactivity. The significant increase in the level of spinal dopamine may be potentially useful in disorders related to a deficit in dopaminergic neurotransmission. These findings could lead to the development of specific supportive therapies for anxiety and symptoms of gradual loss or impairment of motor behaviour.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of <i>Passiflora incarnata</i> L. extract on exploratory behaviour and neurotransmitters level in structures involved in motor functions in rats

Blecharz-Klin,

Pyrzanowska,

Piechal

et al. 2024

J Pre Clin Clin Res.

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show abstract

“…In parallel, new drugs are being developed with the perspective of reducing dependence and opioid withdrawal symptoms [8][9][10]. Medicinal plants [11][12][13] and molecules obtained from medicinal plants [14,15] are options for developing or identifying these new drugs.…”

Section: Introductionmentioning

confidence: 99%

The (–)-Borneol Effect on Addiction/Abstinence by Morphine in Mice

Amaral

Viana

Osório

et al. 2023

DDC

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Opioids such as morphine are the first choice in acute and chronic pain treatment. However, they lead to addiction. Several studies have searched (i) to find a molecule that can replace morphine use or (ii) to reduce its adverse effects. This work aimed to evaluate whether (–)-Borneol [(–)-BOR], a bicyclic monoterpene, in doses of 25, 50, and 100 mg/kg (i.p.), has an antiaddictive effect on morphine (5 mg/kg, i.p.) and reduces its withdrawal symptoms precipitated by naloxone (8 mg/kg, i.p.) in Swiss mice. Furthermore, the (–)-BOR genotoxic potential was also investigated by the comet assay. The antiaddictive effect of (–)-BOR was evaluated by the conditioned preference place (CPP). The CPP was induced by morphine administration during the conditioning phase. The effects of (–)-BOR on the rewarding characteristics of morphine were tested in mice with the administration of (–)-BOR, naloxone, or vehicle (NaCl 0.9%), 30 min before morphine. This work also investigated the (–)-BOR effect on morphine withdrawal symptoms precipitated by naloxone. Morphine withdrawal symptoms were induced by administering morphine twice daily for 5 days, precipitated by naloxone administration on the sixth day. The effect of (–)-BOR on reducing morphine withdrawal symptoms was evaluated in mice that received (–)-BOR before daily morphine administration. Finally, the comet assay was performed to assess the DNA damage degree caused by the (–)-BOR (100 mg/kg, i.p.) administration. The comet assay was performed on peripheral blood taken from the tail of each animal. Cyclophosphamide (50 mg/kg, i.p.) was used to induce DNA damage. After starting the protocol, analyses were performed for 4 h (acute effect) and 24 h (repair effect). The (–)-BOR (100 mg/kg, i.p.) significantly attenuated (*** p < 0.001) the acquisition of morphine-induced CPP and reduced only the jumping behavior in the morphine withdrawal model. The best-studied dose was 100 mg/kg, being evaluated, then, in the comet assay. (–)-BOR at 100 mg/kg did not show the genotoxic effect when compared with the cyclophosphamide group (CYCLO, 50 mg/kg, i.p.) after 4 h or 24 h, a period that corresponded to the repair time of DNA fragmentation. The study showed that (–)-BOR attenuated the acquisition of CPP by morphine and made opioid withdrawal milder. In the comet assay, although (–)-BOR caused DNA damage, this damage was significantly less than the damage by CYCLO, at either 4 h or 24 h after the treatments.

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Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice

Cited by 2 publications

References 67 publications

Effect of <i>Passiflora incarnata</i> L. extract on exploratory behaviour and neurotransmitters level in structures involved in motor functions in rats

Effect of <i>Passiflora incarnata</i> L. extract on exploratory behaviour and neurotransmitters level in structures involved in motor functions in rats

The (–)-Borneol Effect on Addiction/Abstinence by Morphine in Mice

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