SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa

Abstract

SYNTHESIS AND CHARACTERIZATION OF NITROSYL COMPLEXES WITH ANTIBACTERIAL ACTION AGAINST Pseudomonas aeruginosa. The compounds nitrosyl cis-[Ru(bpy)(phen)TU(NO)](PF 6 ) 3 (compound 1) and cis-[Ru(bpy) (phen)(4-N-Imd)(NO)](PF 6 ) 3 (compound 2) (bpy = 2,2'-bipyridine, phen = 1,10'-phenanthroline, TU = thiourea and 4-N-Imd = 4-nitroimidazole) were synthesized and characterized by UV-visible, infrared spectroscopies and electrochemical techniques. In the study of the reactivity it was possible to verify the nitric oxide labilization by square wave voltammetry and a photochemical upon blue light irradiation. This feature is very important for a potential application in phototherapy. Additionally, the antibacterial activity of the nitrosyl complexes was tested against gram-negative bacteria Pseudomonas aeruginosa. Thus, it has been observed that the complexes are capable of inhibiting the growth of such microorganisms.

Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(ii) complexes

“…It is noteworthy that there are not many nitrosyl ruthenium compounds with low MIC/MBC, where most of them do not have any measurable MIC/MBC or values > 25 μg mL −1 . 71,72 A recent paper has pointed out that NO can indeed be beneficial to certain bacteria ( e.g. , Staphylococcus aureus ) that can use it to lower the efficacy of ROS produced by antibiotic agents.…”

“…It is noteworthy that there are not many nitrosyl ruthenium compounds with low MIC/MBC, where most of them do not have any measurable MIC/MBC or values > 25 µg mL −1 . 71,72 A recent paper has pointed out that NO can indeed be beneficial to certain bacteria (e.g., Staphylococcus aureus) that can use it to lower the efficacy of ROS produced by antibiotic agents. 21 These results might support the lack of efficacy of many NO donor systems as antibacterial agents, reinforcing our results that a stable nitrosyl compound can be better indeed.…”