Sinoviortesis radioisotópica en pacientes en edad pediátrica y adolescentes con hemofilia

Effect of radiosynoviorthesis on the progression of arthropathy and haemarthrosis reduction in haemophilic patients

“…The current literature shows that radiosynovectomy is a safe and efficient therapy . However, during years, the question of which agent is optimal for radio‐nucleotide synovectomy has been a controversial issue .…”

“…2,13 The current literature shows that radiosynovectomy is a safe and efficient therapy. [4][5][6][8][9][10][11][12][13][14][15]18 However, during years, the question of which agent is optimal for radio-nucleotide synovectomy has been a controversial issue. [7][8][9]20,21,24 In large joints, such as knee joints, the preferred radionuclide is 90 Y.…”

“…In general, the level of arthropathy is noted to increase with age, except in the range >60 for Non-RSG and in the range [15][16][17][18][19][20][21][22][23][24][25] for RSG on the Gilbert score. Specifically, according to radiological examination, significant differences (P < .05) were found in all age ranges, except between the ranges <15 and 15-25, and between the ranges 40-60 and >60 for both Non-RSG and RSG.…”

“…A first‐line treatment for chronic synovitis is radionuclide synoviorthesis, a widely disseminated method providing satisfactory results in adults, children and adolescents . Chemical synoviorthesis with Rifampicin or oxytetracycline chlorhydrate is a good alternative in developing countries where radionuclide is not available, when it is contraindicated or not tolerated by patients …”

“…3,6 A first-line treatment for chronic synovitis is radionuclide synoviorthesis, a widely disseminated method providing satisfactory results in adults, children and adolescents. [6][7][8][9][10][11][12][13][14][15] Chemical synoviorthesis with Rifampicin or oxytetracycline chlorhydrate is a good alternative in developing countries where radionuclide is not available, when it is contraindicated or not tolerated by patients. 4,16,17 Radiosynoviorthesis (RS) is a minor surgical procedure consisting of a radionuclide infiltration into the joint cavity with the aim of restoring synovial hyperaemia, reducing joint infiltration, decreasing hypertrophy and sclerosis of the vessels of the subsynovial plexus.…”