Sinonasal Undifferentiated Carcinoma: The Search for a Better Outcome

Musy, Pierre Y.; Reibel, James F.; Levine, Paul A.

doi:10.1097/00005537-200208000-00023

Cited by 132 publications

(133 citation statements)

References 11 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…[8][9][10] Orbital involvement, skull base invasion and intracranial extension have been reported in 20-25 per cent of patients. 8,11 In the present series, 25 per cent of patients had intracranial extension, while 19 per cent had intra-orbital extension. Involvement of these critical structures poses a great challenge to achieving complete resection (R0, i.e.…”

Section: Discussionsupporting

confidence: 40%

“…TNM = tumournode-metastasis; 3D = three-dimensional; 5-FU = 5-fluoro-uracil; RT = radiotherapy sinonasal undifferentiated carcinoma with pre-operative radiochemotherapy comprising pre-operative RT (50-54 Gy) and three cycles of cyclophosphamide, doxorubicin plus vincristine chemotherapy. 11 Surgery was performed within 1 month of radiochemotherapy. The authors reported a two-year overall survival rate of 47 per cent for all evaluable patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

et al. 2016

View full text Add to dashboard Cite

Background: Sinonasal undifferentiated carcinoma is a rare aggressive tumour arising from the Schneiderian epithelium lining the sinonasal tract. Although considered the cornerstone of therapy, surgical resection can only be performed in a limited number of patients. This report describes the experience of treating sinonasal undifferentiated carcinoma with a multimodality approach.Method: The treatment charts of sinonasal undifferentiated carcinoma patients treated at a tertiary care centre from 2004 to 2012 were retrospectively reviewed.Results: A total of 16 sinonasal undifferentiated carcinoma patients with a median age at diagnosis of 47.5 years (range 8-65 years) were included: 19 per cent had neck nodal metastasis at presentation. Four patients (25 per cent) underwent surgery: of these, two had post-operative radiotherapy, one had pre-operative radiotherapy and one had adjuvant chemotherapy alone. Six patients (38 per cent) received definitive radiotherapy: five had received neoadjuvant chemotherapy to reduce tumour size and help in radiotherapy planning, while four (25 per cent) received palliative radiotherapy. The median follow up was 10.4 months (range 1-42.5 months). The estimated median progression-free survival time was 29.3 months. One-and three-year progression-free survival rates were 77 per cent and 41 per cent, respectively.Conclusion: Surgery is the best treatment option for sinonasal undifferentiated carcinoma, although most patients require post-operative radiotherapy for advanced disease and close tumour margins. Definitive radiotherapy with or without chemotherapy may be suitable for patients with inoperable locally advanced disease. Elective nodal irradiation to address the high nodal involvement rates should be considered to improve the survival rate.

show abstract

Section: Discussionsupporting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, current series show an overall survival between 40 and 75% [11][12][13][14]. Neck metastases in advanced local disease is a poor prognostic sign [8].…”

Section: Discussionmentioning

confidence: 95%

“…Invasive growth can lead to manifestations such as proptosis, cranial nerve palsies and visual disturbances. In spite of the frequent locally advanced disease at presentation, at this time only 5-13% of patients have nodal metastasis [8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

An Atypical Etiology of Anosmia

Nunes

Janz

Naumann

2017

JOENTR

View full text Add to dashboard Cite

Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor that typically presents with nonspecific symptoms such as epistaxis, nasal obstruction, headache and facial pain. We report an atypical presentation of this neoplasm. Due to the non-specificity of the symptoms and to the fact that SNUC is a highly aggressive tumor, up to 70-90% of patients present with stage T4 disease and overall mortality is high. The purpose of this paper is to alert about an atypical presentation of this tumor and to reinforce the importance of a complete and correct patient evaluation in order to avoid future misdiagnosis. The obvious consequence is an advanced local disease at presentation with a poor prognosis.

show abstract

“…Inspite of these multimodality treatment these tumour recur in one year and most of these patient died. [10]. So early diagnosis and prompt treatment can improve the survival of these patient.…”

Section: Discussionmentioning

confidence: 99%

Primary sinonasal undifferentiated carcinoma with intracranial extension presenting postoperatively as garcin syndrome: a rare case report and review of literature

Prasad¹,

Kumar²,

Kumar³

et al. 2017

Romanian Neurosurgery

View full text Add to dashboard Cite

Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy originating in the mucosa lining the walls of the nasal cavity and paranasal sinuses. It is a rare tumor that usually presents in an advanced stage, is highly invasive, and is traditionally reputed to be refractory to even the most radical therapy with an attendant poor prognosis. This is particularly true when it transgresses the cranial base.

show abstract

Sinonasal Undifferentiated Carcinoma: The Search for a Better Outcome

Cited by 132 publications

References 11 publications

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

An Atypical Etiology of Anosmia

Primary sinonasal undifferentiated carcinoma with intracranial extension presenting postoperatively as garcin syndrome: a rare case report and review of literature

Contact Info

Product

Resources

About