Sinonasal Teratocarcinosarcoma of the Head and Neck

Abstract

To present the clinicopathologic features of 10 sinonasal teratocarcinosarcomas managed at a single center. Teratocarcinosarcoma is a rare morphologically heterogeneous and highly malignant neoplasm. Previous reports of these tumors have focused on their differential diagnosis and histogenesis and consisted of individual case reports and consultation based series.Design: Review of patient medical records and microscopic slides of all tumor tissues. The histopathologic features for each tumor and the demographic, clinical, treatment, and follow-up information were recorded for each patient. Also, a comparison with previously reported series was performed.

Management and clinical outcome of sinonasal teratocarcinosarcoma: single institution experience

“…In a series reported by Smith et al, all the patients were male. 4 In our series, the median age at presentation was 44 years. This disease appears to be of young adults; the majority of reported patients have been over 35 years of age, with only four patients aged less than 20 years being reported.…”

“…1 -4,12 Two larger series have been published: one report of 20 patients by Heffner and Hyams, and a recent report of 10 patients from the M D Anderson cancer centre. 1,4 The data of Heffner and Hyams is based on cases selected from registry of otolaryngic pathology which has multiple contributors. To date, approximately 75 cases of sinonasal teratocarcinosarcoma have been reported, excluding our series.…”

Sinonasal teratocarcinosarcoma involving nasal cavity, nasopharynx, and all paranasal sinuses with bilateral orbital and intracranial extension: A rare case report

“…[10] The most common presentation of SNTCS is nasal obstruction and epistaxis with average duration of symptoms reported as about 3.5 months. [5811] Rare symptoms include eye and/or facial pain, epiphora, headache, vision loss, exophthalmos, and anosmia. [5] Neurological symptoms are rare with SNTCS as they do not usually invade the intracranial space[11] and there are only few reports of neurological symptoms from SNTCS with intracranial extension.…”

“…[234] SNTCS is a highly malignant neoplasm and has a higher rate of recurrence even after gross total resection and is treated with surgery, with or without adjuvant therapies which include radiotherapy and chemotherapy, used alone or in combination. [56] Here, we are presenting a case with SNTCS involving the nasal cavity, nasopharynx, and all paranasal sinuses with bilateral orbital and intracranial extension, whose diagnosis was confirmed by histopathologic examination (HPE) of resected tumor tissues and immunohistochemical examination, treated with surgery followed by radiotherapy and chemotherapy.…”

Epignatus of a Newborn: Postmortem Ct and Mri Imaging for Autopsy

“…Наиболее распространенным гистологическим типом в таких тератомах яв-лялся крупноклеточный рак [36]. К очень ред-ким формам относится и тератокарциносарко-ма полости носа и придаточных пазух [40,41]. Почти все такие опухоли выявлялись у взрослых мужчин и исходили из решетчатой пазухи и верхнечелюстной пазухи [42].…”