Sinonasal Paraganglioma With Long-Delayed Recurrence and Metastases: Genetic and Imaging Findings

Michel, J.; Taïeb, David; Jolibert, M.; Torrents, Julia; Wassef, Michel; Morange, Isabelle; Essamet, Wassim; Barlier, Anne; Dessi, P.; Fakhry, Nicolas

doi:10.1210/jc.2013-2320

Cited by 9 publications

(14 citation statements)

References 20 publications

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“…Differential diagnosis of sinonasal paragangliomas on imaging comprises a broad spectrum of malignant and benign lesions [9], such as esthesioneuroblastomas, gliomas, angiofibromas, hemangiopericytomas, rhabdomyosarcomas, and metastases from neuroendocrine tumors [14]. …”

Section: Discussionmentioning

confidence: 99%

“…There is no gold standard imaging, but CT, MRI, and 18 F-FDG PET/CT have been suggested as first-line exams to assess locoregional extension and/or metastatic lesions [14]. …”

Section: Discussionmentioning

confidence: 99%

“…Patients often complain about recurrent epistaxis, nasal obstruction, facial swelling, frontal headache, and loss of olfaction [4,13]. These tumors must be differentiated from other sinonasal masses, benign and malignant, such as esthesioneuroblastomas, gliomas, angiofibromas, hemangiopericytomas, rhabdomyosarcomas, and metastases from neuroendocrine tumors [14]. They most commonly arise from the ethmoid sinus, followed by lateral nasal wall and middle turbinate, and are slow-growing tumors, tending to present in older patients [5].…”

Section: Introductionmentioning

confidence: 99%

“…Sinonasal paragangliomas are most often diagnosed in middle-aged women with no personal or family history of paragangliomas. The average age at presentation is 45 years, and most patients are between 40 and 60 years old [5,14,15]. Only 3 cases of functioning sinonasal paragangliomas have been described: the first presented as Cushing syndrome and had elevated ACTH levels; the second had a late onset of Cushing's syndrome, presenting 10 years after the first resection; and the last was a catecholamine-secreting tumor in a patient with previous diagnosis of abdominal paragangliomas [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Pediatric paragangliomas insinuate genetic predisposition [4] and screening for multiple germline mutations can be performed, such as SDHB and SDHD, which are the most important for predicting a malignant nature [14,19]. …”

Section: Introductionmentioning

confidence: 99%

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Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Vital¹,

Farias

Dias

et al. 2017

Biomed Hub

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Paragangliomas can be found from the skull base to the sacrum. Sinonasal paragangliomas are infrequent. A 16-year-old female reported spontaneous discrete bilateral epistaxis once a month beginning when she was 3 years of age. Computed tomography showed an expansive hypervascular mass occupying the right nasal cavity and nasopharynx. Sinonasal paragangliomas usually occur in middle-aged women. Radiologic investigation is essential for the diagnosis of sinonasal paragangliomas and evaluating extension of the lesion. Endoscopic and conventional approaches are effective, and preoperative embolization is paramount for reducing bleeding risk. Histopathological features cannot differentiate benign from malignant paragangliomas, and since metastasis may eventually occur, follow-up must be carried out for a long period of time.

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Section: Discussionmentioning

confidence: 99%

“…There is no gold standard imaging, but CT, MRI, and 18 F-FDG PET/CT have been suggested as first-line exams to assess locoregional extension and/or metastatic lesions [14]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Vital¹,

Farias

Dias

et al. 2017

Biomed Hub

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Characteristics and management of sinonasal paragangliomas: a systematic review

Nguyen

Patel

Arianpour

et al. 2018

Int Forum Allergy Rhinol

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Background: Paragangliomas of the nasal cavity and paranasal sinuses, although exceedingly rare, can exhibit frequent and aggressive recurrences. Our objective was to evaluate tumor characteristics, clinical course, management, and associated complications of sinonasal paragangliomas Methods: A systematic review of the literature was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, searching for sinonasal paraganglioma. Studies meeting inclusion criteria were assessed for level of evidence. Patient demographics, tumor characteristics, primary intervention, and other clinical characteristics were evaluated.Results: Forty-five relevant studies encompassing 54 patients with sinonasal paraganglioma were identified. The most common tumor locations were the nasal cavity (66.7%), ethmoid sinuses (22.2%), maxillary sinuses (7.4%), and sphenoid sinuses (3.7%). Common presenting symptoms included recurrent epistaxis (68.5%), nasal obstruction (53.7%), and headache (13.0%). Tumors were malignant in 28.6% of patients. Only 4 cases (7.4%) involved functional tumors. Initial management was always surgical, via either an open (63.0%) or endoscopic (33.3%) approach. Radiotherapy was used as adjunctive treatment in 10 cases (18.5%). Recurrence rate was 21.7% and occurred between 12 to 156 months a er initial resection. The overall survival was 87.0% with a metastatic rate of 8.7%. Conclusion:Sinonasal paragangliomas are vascular neoplasms manifesting clinically with recurrent epistaxis and nasal obstruction. Management goals are total resection with clear margins and long-term follow-up due to tendency for local recurrence. Radiotherapy has been utilized as adjuvant therapy with variable results. Further randomized controlled studies may be invaluable in elucidating these findings. C 2018 ARS-AAOA, LLC.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Sinonasal Paraganglioma With Long-Delayed Recurrence and Metastases: Genetic and Imaging Findings

Abstract: The diagnosis of malignancy remains challenging at initial diagnosis, and patients should be followed during their entire lifetime.

Cited by 9 publications

References 20 publications

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Characteristics and management of sinonasal paragangliomas: a systematic review

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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