Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations — sinonasal analogues to the sialadenoma papilliferum family tumors

Patel, Simmi; Snyderman, Carl H.; Müller, Sarina; Agaimy, Abbas; Seethala, Raja R.

doi:10.1007/s00428-022-03359-8

Cited by 7 publications

(2 citation statements)

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“…4 A recent study has suggested that papillary seromucinous adenocarcinoma with sinonasal papilloma-like surface component (PSASP-like surface) is the sinonasal analog to SP due to the shared morphologic and molecular features. 13 The 2 cases of PSASP-like surface in the study were found to harbor the BRAF V600E mutation. 13 In this current study, all 7 cases of classic SP were positive for BRAF V600E IHC in a moderate to weak intensity, while the oncocytic case was negative for BRAF V600E IHC.…”

Section: Discussionmentioning

confidence: 83%

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Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis

et al. 2023

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Introduction. Sialadenoma papilliferum (SP) is a rare benign neoplasm that usually arises in the minor salivary glands. Recently, it was demonstrated that SP shares similar molecular genetic alterations ( BRAF V600E or HRAS mutations) with its morphologic analog, syringocystadenoma papilliferum. Methods. We sought to perform clinicopathologic and immunophenotypic (BRAF V600E and SOX10) analyses on 8 new cases of SP. Results. The cases were from 4 males and 4 females, with ages ranging from 28 to 81 years (average: 64 years). The common locations were the hard palate (n = 3) and buccal mucosa (n = 3). Histopathologically, 7 cases were classic and 1 case was oncocytic. BRAF V600E immunohistochemistry (IHC) was positive in all classic SP, involving both the exophytic and endophytic components, but negative in the oncocytic SP. SOX10 was positive in the endophytic ductal cells of the evaluated classic SP but was negative in the oncocytic SP. Conclusions. We report 8 new cases of this rare salivary gland neoplasm, using BRAF V600E and SOX10 IHC to further support the following points: (1) the functional role of BRAF V600E mutation, RAS/mitogen-activated protein kinase signaling pathway in the pathogenesis of classic SP of salivary glands by IHC; (2) the analogous relationship between SP, syringocystadenoma papilliferum, and papillary seromucinous adenocarcinoma with sinonasal papilloma-like surface component (PSASP-like surface); (3) endophytic ductal component in classic SP arises from the intercalated ducts and not the excretory ducts; and (4) oncocytic SP is distinct from classic SP.

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Section: Discussionmentioning

confidence: 83%

“…13 The 2 cases of PSASP-like surface in the study were found to harbor the BRAF V600E mutation. 13 In this current study, all 7 cases of classic SP were positive for BRAF V600E IHC in a moderate to weak intensity, while the oncocytic case was negative for BRAF V600E IHC.…”

Section: Discussionmentioning

confidence: 83%