Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy

Abstract

Patients with inverted papilloma should undergo thorough surgery to remove all mucosal disease, most probably by the endoscopic, endonasal route when complete resection is possible. Cases demonstrating atypia or dysplasia may be treated by the endoscopic route. Recurrent disease and metachronous carcinoma can develop after a prolonged period of time. Long-term follow up is recommended to detect recurrence, as disease can become quite extensive before it becomes symptomatic.

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

“…A recent large series of inverted papillomas reported by Mirza et al [5] described synchronous carcinomas in 7.1% (163/2,297 cases) and metachronous carcinoma in 75/2,047 cases implying a malignant transformation rate of 3.6%. In the same series atypia was associated with inverted papilloma in 9% of cases, dysplasia in 12% and carcinoma in situ in 3.4%.…”

Bilateral inverted papilloma: A report of two cases and review of the current literature

“…It is more common in men and usually presents in the fifth and sixth decades of life [10]. Unilateral disease and unilateral nasal obstruction is the most common presenting feature [11,12] but, as demonstrated in this article, bilateral disease does occur with reported rates of 2-7% [1,6,7]. The etiology of this multicentric appearance has yet to be fully understood.…”

“…A recent series published from the UK had a reported rate of just under 7% for bilateral involvement [1] whilst other series report rates typically between 2% and 4% [6,7]. In this article we describe two cases of bilateral inverted papilloma which presented to our department, discuss the possible treatment options available and highlight some important management issues.…”

“…Inverted papilloma is a benign sinonasal tumor which is locally aggressive and has a well recognized malignant potential with a transformation rate often quoted in the literature in the region of 2.1-7% [1][2][3]. It has been documented across all ages and constitutes 0.5-4% of all sinonasal tumors [4].…”

Prevalence of occupational hazards in patients with different types of epithelial sinonasal cancers

“…Occupational factors are responsible for a huge proportion of epithelial SNC besides other established congenital or acquired risk factors such as previous radiotherapy in the region and tobacco smoking (9) , chromosomal and genetically determined alterations (10,11) , inverted papilloma (12) .…”