Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study

El‐Naggar, Adel K.; Batsakis, John G.; Garcia, Glenn M.; Luna, Mario L.; Goepfert, Helmuth

doi:10.1001/archotol.1992.01880020026010

Cited by 48 publications

(17 citation statements)

References 10 publications

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“…In the event of recurrence of which the incidence is according to the literature from 9.5% to 50%, depending on the length of the followup, a reresection is considered as the treatment of first choice [39]. Although an adjuvant radiation may reduce the risk of recurrence, it is controversially discussed due to the good outcome after the reresection and the side effects of radiation of the head and neck [20].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review

Ledderose

Gellrich

Holtmannspötter

et al. 2013

Case Reports in Otolaryngology

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Objectives. Hemangiopericytoma is a rare tumor entity deriving from pericytes. Less than 5% of hemangiopericytoma occur in the nasal cavity and are characterised by a rather benign nature with low tendency of metastasis. However, as the recurrence rate in the literature ranges from 9.5% to 50%—depending on the length of followup—a radical surgical resection is considered as the gold-standard treatment. Only a few years ago, a wide external approach, usually via lateral rhinotomy or Caldwell-Luc, was performed. Endoscopic techniques were regarded as appropriate for small low-vascularised tumors only. Methods. We present the case of a 64-year-old patient with an extended sinonasal hemangiopericytoma, who was successfully treated by an endoscopic controlled endonasal tumor resection after embolisation with Onyx. Further, to support the new treatment option, we review the literature concerning all features of sinonasal hemangiopericytomas and their therapeutical management. Results/Conclusion. Onyx, which has not been described in the context of hemangiopericytoma yet, is a very effective embolic agent for a preoperative embolisation of sinonasal hemangiopericytoma allowing a safe endoscopic surgery.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review

Ledderose

Gellrich

Holtmannspötter

et al. 2013

Case Reports in Otolaryngology

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“…With a peak in the 7th decade (range, in utero to 86 years), there is a slight female predominance. This tumor is mostly unilateral, affecting the nasal cavity alone, occasionally extending into the paranasal sinuses, with about 5 % bilateral [6,[11][12][13][14]. The majority of patients experience nasal obstruction and epistaxis, with a wide range of other non-specific findings (polyps, sinusitis, headaches, difficulty breathing, congestion), usually present for less than 1 year on average.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…GPCs are indolent tumors, with an overall excellent survival ([90 % 5-year survival) achieved with complete surgical excision. Recurrences, in up to 40 % of cases, are usually a result of inadequate resection, with the recurrence affecting the same site, occurring from a few months up to two decades after the initial surgery [6,11,13,14,16,17]. Aggressive behavior (malignant GPC) is uncommon, suggested by large tumors ([5 cm), bone invasion, profound nuclear pleomorphism, increased mitotic activity ([4/10 high power fields; Ki-67 proliferation index of [10 %), and necrosis, with rare metastasis reported [6,[11][12][13]18].…”

Section: Clinical Featuresmentioning

confidence: 99%

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Thompson

Fanburg‐Smith

2016

Head and Neck Pathol

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“…Sinonasal hemangiopericytoma (HPC) is a rare tumor of perivascular myoid differentiation that arises uniquely in the nasal cavity and paranasal sinuses, and which constitutes \1 % of all sinonasal tumors [1][2][3]. Tumors arise most commonly in adults, affect women and men at approximately equal frequencies, and show relatively frequent local recurrence (up to 20 %) but virtually no metastases [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Tumors arise most commonly in adults, affect women and men at approximately equal frequencies, and show relatively frequent local recurrence (up to 20 %) but virtually no metastases [1][2][3]. Histologically, sinonasal HPC is comprised of uniform, bland spindled and rounded tumor cells with ovoid nuclei and palely eosinophilic cytoplasm arranged in sheets, whorls, or short fascicles.…”

Section: Introductionmentioning

confidence: 99%

Nuclear β-Catenin Expression is Frequent in Sinonasal Hemangiopericytoma and Its Mimics

Fletcher

2016

Head and Neck Pathol

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Sinonasal hemangiopericytoma (HPC) is a tumor showing pericytic myoid differentiation and which arises in the nasal cavity and paranasal sinuses. CTNNB1 mutations appear to be a consistent aberration in sinonasal HPC, and nuclear expression of b-catenin has been reported. Our aim was to evaluate the frequency of b-catenin expression in sinonasal HPC and its histologic mimics in the upper aerodigestive tract. Cases were retrieved from the surgical pathology and consultation files. Immunohistochemical staining for b-catenin was performed on 50 soft tissue tumors arising in the sinonasal tract or oral cavity, and nuclear staining was recorded semiquantitatively by extent and intensity. Nuclear reactivity for b-catenin was present in 19/20 cases of sinonasal HPC; 17 showed moderate-to-strong multifocal or diffuse staining, and 2 had moderate focal nuclear reactivity. All solitary fibrous tumors (SFT) (10/10) showed focal-to-multifocal nuclear staining, varying from weak to strong in intensity. Most cases of synovial sarcoma (9/10) showed nuclear b-catenin expression in the spindle cell component, ranging from focal-weak to strong-multifocal. No cases of myopericytoma (0/10) showed any nuclear b-catenin expression. bcatenin expression is prevalent in sinonasal HPC, but is also frequent in SFT and synovial sarcoma. Our findings indicate that b-catenin is not a useful diagnostic tool in the evaluation of spindle cell tumors with a prominent hemangiopericytoma-like vasculature in the sinonasal tract and oral cavity, and that definitive diagnosis relies on the use of a broader immunohistochemical panel.

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Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study

Cited by 48 publications

References 10 publications

Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review

Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Nuclear β-Catenin Expression is Frequent in Sinonasal Hemangiopericytoma and Its Mimics

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