Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues

Tong, Bei; Yu, Jinghu; Wang, Ting; Dou, Youjun; Wu, Xin; Kong, Ling‐Yi; Dai, Yue; Xia, Yufeng

doi:10.1016/j.molimm.2015.01.014

Cited by 55 publications

(39 citation statements)

References 33 publications

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“…SIN increased the frequency of Treg cells and decreased the frequency of Th17 cells, which was consistent with our previous findings in rat CIA. 2 Notably, the reciprocal regulatory effect of SIN on Th17 and Treg cells was almost completely reversed by RES treatment, indicating that SIN might recover Th17/Treg balance in an AhR-dependent manner. (Figure 5h).…”

Section: Sin Acted As An Ahr Ligandmentioning

confidence: 96%

“…24 Recently, we investigated the immunomodulatory effect of SIN in rat CIA, an animal model of RA whose development is dependent on the participation of Th17 and Treg cells. 2 Treatment of CII-immunized rats with SIN resulted in a dose-dependent inhibition of arthritis severity through the recirculation of lymphocytes from the gut to the inflamed joint. 2 The present study was designed to investigate how SIN affects the differentiation and function of these cells.…”

Section: Sin Acted As An Ahr Ligandmentioning

confidence: 99%

“…2 Treatment of CII-immunized rats with SIN resulted in a dose-dependent inhibition of arthritis severity through the recirculation of lymphocytes from the gut to the inflamed joint. 2 The present study was designed to investigate how SIN affects the differentiation and function of these cells. In vitro, SIN increased the differentiation of Treg cells, and decreased the differentiation of Th17 cells.…”

Section: Sin Acted As An Ahr Ligandmentioning

confidence: 99%

“…1 Recently, our group reported that SIN functions by restoring systemic IL-17-producing T-cells (Th17)/regulatory T-cells (Treg) balance by inducing the generation of intestinal Treg cells and the migration of these cells to inflamed joint and synovium. 2 This unique gut-dependent action mode of SIN led us to explore its immunomodulatory action and mechanism in more detail.…”

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confidence: 99%

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Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor

Tong

Yuan

Dou

et al. 2016

Laboratory Investigation

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Section: Sin Acted As An Ahr Ligandmentioning

confidence: 96%

Section: Sin Acted As An Ahr Ligandmentioning

confidence: 99%

Section: Sin Acted As An Ahr Ligandmentioning

confidence: 99%

mentioning

confidence: 99%

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Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor

Tong

Yuan

Dou

et al. 2016

Laboratory Investigation

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“…Its intraperitoneal (i.p.) administration shows to be effective for the treatment of RA by suppressing IL‐6, MMP‐2 and MMP‐9 in arthritic animal model …”

Section: Herbal Pharmacotherapy In Rheumatoid Arthritismentioning

confidence: 99%

Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery

Rahman

Beg

Verma

et al. 2016

Journal of Pharmacy and Pharmacology

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The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products

Wang

Zhou

et al. 2021

ChemMedChem

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Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.

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Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues

Cited by 55 publications

References 33 publications

Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor

Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor

Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery

The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products

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