Sinomenine Suppress the Vitamin D3 and High Fat Induced Atherosclerosis in Rats via Suppress of Oxidative Stress and Inflammation

Geng, PengBo; Xu, Xin; Gao, Zhili

doi:10.5650/jos.ess21255

Cited by 11 publications

(8 citation statements)

References 49 publications

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“…Sinomenine is the main active ingredient isolated from the Chinese medicinal Caulis Sinomenii for the treatment of rheumatic diseases, and has the biological effects of anti-inflammation, anti-oxidation, inhibition of apoptosis, immunosuppression, etc ( 56 – 58 ). Clinical studies have shown that ( 59 , 60 ) sinomenine has a significant effect on the treatment of RA.…”

Section: Alkaloidmentioning

confidence: 99%

“…TLR-dependent MAPK signaling pathway is a key pathway for mediating the occurrence of RA ( 209 ). Studies have shown that NF-κB and MAPKs (three major kinases: JNK, p38 and ERK) are expressed in cultured RA-FLSs and easily activated by IL-1β and TNF-α ( 58 , 59 ), involving in RA inflammation and joint destruction. Inhibition of activation or downregulation of MAPK signaling pathway weakens the inflammatory response and oxidative stress in RA model, inhibits the proliferation, migration and invasion of FLSs, regulates the body immunity, and inhibits osteoclastogenesis.…”

Section: Mechanism Of Action Against Ramentioning

confidence: 99%

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Natural medicines of targeted rheumatoid arthritis and its action mechanism

Wang

Qian

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical manifestations of joint inflammation, bone damage and cartilage destruction, joint dysfunction and deformity, and extra-articular organ damage. As an important source of new drug molecules, natural medicines have many advantages, such as a wide range of biological effects and small toxic and side effects. They have become a hot spot for the vast number of researchers to study various diseases and develop therapeutic drugs. In recent years, the research of natural medicines in the treatment of RA has made remarkable achievements. These natural medicines mainly include flavonoids, polyphenols, alkaloids, glycosides and terpenes. Among them, resveratrol, icariin, epigallocatechin-3-gallate, ginsenoside, sinomenine, paeoniflorin, triptolide and paeoniflorin are star natural medicines for the treatment of RA. Its mechanism of treating RA mainly involves these aspects: anti-inflammation, anti-oxidation, immune regulation, pro-apoptosis, inhibition of angiogenesis, inhibition of osteoclastogenesis, inhibition of fibroblast-like synovial cell proliferation, migration and invasion. This review summarizes natural medicines with potential therapeutic effects on RA and briefly discusses their mechanisms of action against RA.

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Section: Alkaloidmentioning

confidence: 99%

Section: Mechanism Of Action Against Ramentioning

confidence: 99%

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Wang

Qian

et al. 2022

Front. Immunol.

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“…The sinomenine is very popular herb among the Chinese doctors to treat the various inflammatory disease such as rheumatic ( Zhou et al, 2020 , Lin et al, 2008 ). Some pharmacological investigation showed that it has remarkable anti-inflammatory, antiarthritic and analgesic effect ( Geng et al, 2021 , Li et al, 2021 ). Last few decades, sinomenine widely used for the treatment of chronic glomerulonephritis, allograft rejection, autoimmune nephritis condition and mesangial proliferative nephritis ( Zhou et al, 2020 , Zhang et al, 2012 , Lin et al, 2008 , Li et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Last few decades, sinomenine widely used for the treatment of chronic glomerulonephritis, allograft rejection, autoimmune nephritis condition and mesangial proliferative nephritis ( Zhou et al, 2020 , Zhang et al, 2012 , Lin et al, 2008 , Li et al, 2021 ). Recent investigation showed that sinomenine suppress the synovial and lymphocyte fibroblast proliferation, macrophage infiltration and the production of inflammatory cytokines ( Geng et al, 2021 , Yang et al, 2017 , Li et al, 2021 ). As my best knowledge, the myocardial protective effect of sinomenine against the I/R induced ventricular arrhythmias not explored.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model

Lu¹,

X²,

et al. 2022

Saudi Pharmaceutical Journal

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“…Sinomenine is known for its obvious therapeutic effects, such as anti-inflammatory, immunosuppressive, antioxidant, antiarrhythmic and anti-cancer. [26][27][28][29][30][31][32][33] It is widely used in the clinical treatment of rheumatoid diseases. In addition, some studies have found that sinomenine has an effect on bone metabolism.…”

mentioning

confidence: 99%

Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs

Li¹,

Li²,

Zou³

et al. 2022

DDDT

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To investigate the effects of sinomenine on orthodontic tooth movement and root resorption in rats, as well as the effect of sinomenine on the osteogenesis of periodontal ligament stem cells (PDLSCs). Methods: Fifty-four male Wistar rats were randomly divided into 3 groups: control group, 20 mg/kg sinomenine group and 40 mg/kg sinomenine group. Fifty-gram orthodontic force was applied to all groups. Each group was injected intraperitoneally with corresponding concentration of sinomenine every day. After 14 days, all rats were sacrificed. Micro-computed tomography (micro-CT) scan was used to analyze tooth movement, root resorption and alveolar bone changes. The effect on periodontal tissue was analyzed by Masson, tartrate-resistant acid phosphatase (TRAP) and immunohistochemical staining. In vitro, PDLSCs were extracted and identified. The effect of sinomenine on proliferation was determined by cell-counting kit-8. The effect of sinomenine on osteogenesis was investigated by alkaline phosphatase (ALP) activity and alizarin red staining. qPCR and Western blotting were performed to explore the effects of sinomenine on the expression levels of ALP, runt-related transcription factor 2 (RUNX2), receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG). Results:The tooth movement and root resorption of sinomenine groups were reduced. Sinomenine decreased trabecular spacing on compression side and increased alveolar bone volume and trabecular thickness on tension side. TRAP-positive cells in sinomenine groups decreased significantly. The expressions of TNF-α and RANKL were decreased, while the expressions of OPG, RUNX2 and osteocalcin were up-regulated. In vitro, 0.1 M and 0.5 M sinomenine enhanced ALP activity, mineral deposition and the expression of ALP, RUNX2 and OPG, and reduced the expression of RANKL. Conclusion: Sinomenine could inhibit tooth movement, reduce root resorption, and exert a positive effect on bone formation in rats. Moreover, sinomenine promoted the osteogenesis of PDLSCs.

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Sinomenine Suppress the Vitamin D3 and High Fat Induced Atherosclerosis in Rats via Suppress of Oxidative Stress and Inflammation

Cited by 11 publications

References 49 publications

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Natural medicines of targeted rheumatoid arthritis and its action mechanism

Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model

Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs

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