2011
DOI: 10.5897/ajb10.757
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Sinomenine induces apoptosis of prostate cancer cells by blocking activation of NF-kappa B

Abstract: Sinomenine (SN) is an alkaloid that has previously been shown to have a role in such varied processes as inflammation, angiogenesis, arthritis and immunosuppression. Therefore, in this study, possible anti-tumor effects of SN on the human prostate cancer cell lines, PC-3 and DU-145, was investigated. After treatment with varying doses of SN, apoptosis was measured by flow cytometry. Prostaglandin E2 production was detected by ELISA, and expression levels of cyclooxygenase-2 and nuclear factorkappa B were evalu… Show more

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Cited by 8 publications
(3 citation statements)
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“…GEFs catalyze the activation of the members of the Rho GTPase family, which constitute central players in actin cytoskeleton remodeling and focal cell adhesion [55,56]. Both ARAP3 and ARHGEF2 have been associated with increased migration, invasion, and metastatic behavior in various cancer types [57][58][59][60][61]. The downregulation of these migration-and metastasis-associated factors may thus help to partly explain the reduced migration we observed upon miR-4646-5p mimic transfection.…”
Section: Discussionmentioning
confidence: 84%
“…GEFs catalyze the activation of the members of the Rho GTPase family, which constitute central players in actin cytoskeleton remodeling and focal cell adhesion [55,56]. Both ARAP3 and ARHGEF2 have been associated with increased migration, invasion, and metastatic behavior in various cancer types [57][58][59][60][61]. The downregulation of these migration-and metastasis-associated factors may thus help to partly explain the reduced migration we observed upon miR-4646-5p mimic transfection.…”
Section: Discussionmentioning
confidence: 84%
“…In 2011, J. Fan and team demonstrated that SIN (0.006–0.304 μM) induced apoptosis in prostate cancer cells PC-3 and DU-145 by downregulating prostaglandin E2 (PGE2), cyclooxygenase 2 (COX-2), and NF-κB (as shown in Figure 3 ) and reducing NF-κB-p65 levels (IC 50 value was 121.4 μM) [ 22 ]. In the subsequent year, L.P. Zhou’s group observed that SIN (607.1 μM) inhibited NCI-H460 cell proliferation by obstructing the AKT and ERK1/2 pathways [ 23 ].…”
Section: Antitumor Activitymentioning
confidence: 99%
“…T.T. Zhou et al synthesized asymmetric pyrazin-SIN derivatives, finding that compounds such as 9a (22), 10a (23), 11a (24), 14a (25), and 18b (26) were more effective than SIN in inhibiting TNF-α production in LPS-stimulated mouse peritoneal macrophages, with an inhibition rate exceeding 95% at a 10 µM dosage [143].…”
Section: Anti-inflammatory Activity and Analgesic Activity Of Compoun...mentioning
confidence: 99%