Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway

Wang, Xiaoqing; Liu, Yatao; Zhang, Hong; Jin, Jianping; Ma, Yan; Leng, Yufang

doi:10.1016/j.ejphar.2021.173945

Cited by 22 publications

(17 citation statements)

References 27 publications

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“…It has been reported that the effects of paclitaxel are dose-dependent, with the higher doses triggering axonal degeneration and lower doses triggering hypersensitivity pain, including allodynia and hyperalgesia [47]. Neurotoxicity induced by PTX is ascribed to altered microtubule structure, which induces enhanced microtubule stability by increasing acetylated α-tubulin triggering neuropathic pain, but it has been recently reported that PTX also causes inflammation in DRG neurons in culture [48,49]. Although the mechanism by which PTX injures peripheral sensory fibers is not identified, it has been indicated that PTX impairs axoplasmic transport [50], leads to neuronal mitochondria dysfunction [51], and supports epithelial damage leading to axonal degeneration [52].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain

et al. 2021

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Chemotherapy-induced peripheral neuropathy (CIPN) represents one of the most prevalent and potentially disabling side effects due to the use of anticancer drugs, one of the primary neuropathies detected is peripheral neuropathy induced by administration of taxanes, including paclitaxel. It has been demonstrated that gut microbiota is crucial for the therapeutic effect of chemotherapeutic drugs for inhibiting tumor growth and contributed to the pathogenesis of the CIPN. The use of nutraceuticals has receiving growing attention from the research community due to their phytochemical, biological, and pharmacological properties. It has been demonstrated that probiotic formulations may both reduce inflammation and modulate the expression of pain receptors. Our studies tested the efficacy of a probiotic formulation, SLAB51, in preventing paclitaxel-induced neuropathy. Interestingly, our probiotic formulation was able to keep the gut integrity, preserving its functionality, in CIPN-mice, moreover, it prevented the mechanical and cold hypersensitivity induced in paclitaxel-mice. Additionally, ex-vivo analysis showed that in CIPN-mice the pro-biotic treatment increased the expression of opioid and cannabinoid receptors in spinal cord, it prevented in the reduction in nerve fiber damage in the paws and modulated the serum proinflammatory cytokines concentration. On basis of these data, the use of this specific probiotic formulation may represent a valid adjuvant agent to paclitaxel, useful and not toxic for long-lasting therapies.

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Section: Discussionmentioning

confidence: 99%

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain

et al. 2021

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“…It has unique pharmacological properties and can be used in the treatment of inflammatory and autoimmune diseases [22]. Sinomenine has been widely reported in the treatment of rheumatoid arthritis and neuralgia [9,23]. In addition, the antitumor effects of sinomenine have been found in various cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Sinomenine is a monomer alkaloid component extracted from Caulis Sinomenii, which belongs to isoquinoline alkaloid. Sinomenine has anti-inflammatory, antirheumatism, antitumor, sedation, antihypertensive, antiarrhythmia, immunosuppression, and other pharmacological effects [9][10][11]. Numerous experiments have shown that sinomenine can inhibit the development of breast cancer, stomach cancer, lung cancer, and ovarian cancer [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression

Xu¹,

Dong

Hou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Sinomenine has been reported to effectively repress the progression of lung cancer and breast cancer. However, the effects of sinomenine in bladder cancer are not well understood. The purpose of this study was to evaluate the effects of sinomenine in bladder cancer. Methods. The mRNA expression of HEIH in bladder cancer cells was measured by RT-qPCR. T24 and SW780 cells were treated with sinomenine for 24 hours. Cell viability was detected by the MTT assay. Cell migration and invasion were detected by the transwell assay. Western blotting assay was performed to assess the protein expression of Bcl-2, Bax, and caspase-3. Results. Sinomenine significantly suppressed cell viability in T24 and SW780 cells. Moreover, cell migration and invasion were significantly inhibited by sinomenine. Sinomenine accelerated the expression of Bax and caspase-3 but decreased the expression of Bcl-2. HEIH was upregulated in bladder cancer cells compared with normal bladder epithelial cells. Besides this, we noticed that HEIH knockdown blocked cell proliferation, migration, and invasion but facilitated cell apoptosis in bladder cancer cells. Additionally, HEIH reversed the suppression of the progression induced by sinomenine. Conclusion. Sinomenine was observed to suppress cell progression of bladder cancer cells by inhibiting HEIH expression. Our findings suggested that the use of sinomenine might be an effective treatment for bladder cancer.

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“…Sinomenine ( Table 2 ) significantly reduced the expression of various factors related to inflammation, including p38 MAPK, NF-κB, c-fos, p-CAMKII, COX-2, p-CREB, TLR4 and IL-17A (Model: cultured dorsal root ganglia cell line, spinal nerve ligation model, cancer-induced bone pain model; Dosage: 800 μmol/L, 20, 40 mg/kg; Control: sham operation and vehicle; Positive control: KN93, SB203580 and oxycodone) ( Chen SP. et al, 2018 ; Wang et al, 2021 ). Sinomenine can also inhibit the expression of transcription factor NF-κB, to further reduce the production of TNF, IL-1β, IL-6, INF-γ, IL-4, and IL-8, thereby alleviates neurogenic inflammation (Model: collagen-induced arthritis in mice, Freund’s complete adjuvant-induced adjuvant arthritis rats model; Dosage: 30, 100, 300 mg/kg; Positive control: dexamethasone) ( Wang Y. et al, 2005 ; Li et al, 2006 ; Feng et al, 2007 ).…”

Section: Direct and Background Efficacy Of Traditional Chinese Medici...mentioning

confidence: 97%

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management

et al. 2022

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Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine, sinomenine, ligustrazine, evodiamine, brucine, tetrandrine, Stopholidine, and lappaconitine, focusing on their mechanisms and potential clinical applications. To better describe the mechanism of these alkaloids, we adopted the concept of drug-cloud (dCloud) theory. dCloud illustrated the full therapeutic spectrum of multitarget analgesics with two dimensions, which are “direct efficacy”, including inhibition of ion channels, activating γ-Aminobutyric Acid/opioid receptors, to suppress pain signal directly; and “background efficacy”, including reducing neuronal inflammation/oxidative stress, inhibition of glial cell activation, restoring the balance between excitatory and inhibitory neurotransmission, to cure the root causes of chronic pain. Empirical evidence showed drug combination is beneficial to 30–50% chronic pain patients. To promote the discovery of effective analgesic combinations, we introduced an ancient Chinese therapeutic regimen that combines herbal drugs with “Jun”, “Chen”, “Zuo”, and “Shi” properties. In dCloud, “Jun” drug acts directly on the major symptom of the disease; “Chen” drug generates major background effects; “Zuo” drug has salutary and supportive functions; and “Shi” drug facilitates drug delivery to the targeted tissue. Subsequently, using this concept, we interpreted the therapeutic effect of established analgesic compositions containing TCM derived analgesic alkaloids, which may contribute to the establishment of an alternative drug discovery model.

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Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway

Cited by 22 publications

References 27 publications

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain

Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management

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