Sino-nasal Cancer in Denmark 1982-1999 - A Nationwide Survey

Grau, Cai; Jakobsen, Mikkel Holmelund; Harbo, Grethe; Svane-Knudsen, Viggo; Wedervang, Kim; Larsen, Signe Benzon; Rytter, Carsten

doi:10.1080/028418601750070993

Cited by 76 publications

(15 citation statements)

References 4 publications

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“…As we found in our study, the predominance of men was obvious in previous works (10,11). The majority of neoplasms occurred in the fifth decade of life which are in support with findings in previous studies (2,3). …”

Section: Discussionsupporting

confidence: 92%

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Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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BackgroundInadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors.Material and MethodsClinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor.ResultsThere were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy.ConclusionsParanasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies. Key words:Paranasal sinuses, malignancy, surgery,radiotherapy.

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Section: Discussionsupporting

confidence: 92%

“…There are different factors making diagnosis of these tumors a major challenge including different histological variations, limited anatomic access, and nonspecific clinical manifestations (2,3). …”

Section: Introductionmentioning

confidence: 99%

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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“…Nasal cavity and paranasal sinus cancer has an incidence of less than 1 per 100,000 persons per year, 2 the frontal sinus being involved in less than 0.3% of these cases. 3,4 Histologically, squamous cell carcinoma is the most common cause of these tumours, making up more than 40% of cases with adenocarcinoma responsible for around 13–19% of cases. 3,5,6 These cancers tend to present most commonly between 50–70 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Histologically, squamous cell carcinoma is the most common cause of these tumours, making up more than 40% of cases with adenocarcinoma responsible for around 13–19% of cases. 3,5,6 These cancers tend to present most commonly between 50–70 years of age. 5 Men are affected significantly more than women.…”

Section: Discussionmentioning

confidence: 99%

Frontal sinus cancer resection and reconstruction

Mannu

Iyer

Shah³

2011

JRSM Short Reports

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“…Despite improvements in surgery and radiotherapy (RT) during the last years, patients with advanced stage maxillary sinus carcinoma still have a dismal prognosis, yielding 5-year overall survival rates of 35–49% [10, 11]. Study results suggest that surgery should be incorporated into a treatment regime for patients treated with curative intent [12].…”

Section: Introductionmentioning

confidence: 99%

Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus: A 26-Year Experience

Kreppel

Danscheid

Scheer

et al. 2012

Chemotherapy Research and Practice

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Background. The aim of our study was to evaluate the effects of neoadjuvant platinum-based radiochemotherapy (RCT) in patients with maxillary sinus squamous cell carcinoma and to compare the results with other multimodality treatment concepts for advanced-stage maxillary sinus carcinoma in the literature. Methods. In total, 53 patients with squamous cell carcinoma of the maxillary sinus were reviewed retrospectively. All patients received a neoadjuvant RCT containing either cisplatin or carboplatin followed by radical surgery. Overall survival and locoregional control were plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis. Results. Five-year overall survival for all patients was 35%. Eleven patients achieved a complete response after radiochemotherapy. The complete response rate was significantly higher for patients treated with cisplatin (P = 0.028); however the 5-year overall survival rates did not differ significantly (P = 0.673) for patients treated with cisplatin (37%) and carboplatin (32%). Orbital invasion (P = 0.005) and complete response to radiochemotherapy (P = 0.021) had a significant impact on overall survival in univariate analysis. Conclusions. Neoadjuvant radiochemotherapy followed by radical surgery is an effective treatment for patients with advanced maxillary sinus squamous cell carcinoma. In terms of treatment response cisplatin seems to be more effective than carboplatin.

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Sino-nasal Cancer in Denmark 1982-1999 - A Nationwide Survey

Cited by 76 publications

References 4 publications

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Frontal sinus cancer resection and reconstruction

Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus: A 26-Year Experience

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