Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages

Lee, Hee-Weon; Lee, Chung Gi; Rhee, Dong‐Kwon; Um, Sung Hee; Pyo, Suhkneung

doi:10.1016/j.intimp.2017.01.032

Cited by 46 publications

(26 citation statements)

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“…Previous studies have revealed that NF‐κB signaling pathway is one of the most important pathways that are activated in macrophages under the pathogen challenge . Thus, we aimed to study whether the anti‐inflammatory ability of curcumin is associated with NF‐κB signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that NF-κB signaling pathway is one of the most important pathways that are activated in macrophages under the pathogen challenge. [34][35][36][37][38] Thus, we aimed to study whether the anti-inflammatory ability of curcumin is associated with NF-κB signaling pathway. By examining the protein expression levels via Western Blotting, we found that IAV infection leads to the decrease in IκBα and cytosolic p65, while enhanced the levels of p-IκBα and nuclear p65.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF‐κB signaling pathway

Liu

2017

Influenza Resp Viruses

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BackgroundInfluenza A viruses (IAV) result in severe public health problems with worldwide each year. Overresponse of immune system to IAV infection leads to complications, and ultimately causing morbidity and mortality.ObjectiveCurcumin has been reported to have anti‐inflammatory ability. However, its molecular mechanism in immune responses remains unclear.MethodsWe detected the pro‐inflammatory cytokine secretion and nuclear factor kappa‐light‐chain‐enhancer of activated B cell (NF‐κB)‐related protein expression in human macrophages or mice infected by IAV with or without curcumin treatment.ResultsWe found that the IAV infection caused a dramatic enhancement of pro‐inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after IAV infection downregulated these cytokines production in a dose‐dependent manner. Moreover, the NF‐κB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF‐κB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B‐cells inhibitor, alpha (IκBα), and inhibiting the translocation of p65 from cytoplasm to nucleus.ConclusionsIn summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF‐κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF‐κB signaling pathway

Liu

2017

Influenza Resp Viruses

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“…Reduction of liver fibrosis [220] Suppression of NF-κB/MAPK and NLRP3 inflammasome activation in macrophages [221] Promotion of wound healing [113,222] Anti-cancer properties in methyl glyoxal modification [223] Anti-proliferative activity on carcinogen-induced hepatotoxicity [224] Biofumigation of potato cyst nematode [21] Inhibition of Listeria monocytogenes on bologna sausages [112] inhibition of invasion, migration, MMP-2/-9 activities in SK-Hep 1 human hepatoma cells [225] Brussel sprout juice mediated effects on cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro [226] AITC mediated mitotic block, loss of cell adhesion/disrupted cytoskeleton in HT29 cells [227] Cytotoxicity and genotoxicity of allyl and phenethyl isothiocyanates, glucosinolates, sinigrin and gluconasturtiin [228] Inhibition of microbial growth [47,65,229] Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats [230]…”

Section: Application Referencementioning

confidence: 99%

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

Melrose

2019

Biomedicines

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This study reviewed aspects of the biology of two members of the glucosinolate family, namely sinigrin and glucoraphanin and their anti-tumour and antimicrobial properties. Sinigrin and glucoraphanin are converted by the β-sulphoglucosidase myrosinase or the gut microbiota into their bioactive forms, allyl isothiocyanate (AITC) and sulphoraphanin (SFN) which constitute part of a sophisticated defence system plants developed over several hundred million years of evolution to protect them from parasitic attack from aphids, ticks, bacteria or nematodes. Delivery of these components from consumption of cruciferous vegetables rich in the glucosinolates also delivers many other members of the glucosinolate family so the dietary AITCs and SFN do not act in isolation. In vitro experiments with purified AITC and SFN have demonstrated their therapeutic utility as antimicrobials against a range of clinically important bacteria and fungi. AITC and SFN are as potent as Vancomycin in the treatment of bacteria listed by the World Health Organisation as antibiotic-resistant “priority pathogens” and also act as anti-cancer agents through the induction of phase II antioxidant enzymes which inactivate potential carcinogens. Glucosinolates may be useful in the treatment of biofilms formed on medical implants and catheters by problematic pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus and are potent antimicrobials against a range of clinically important bacteria and fungi. The glucosinolates have also been applied in the prevention of bacterial and fungal spoilage of food products in advanced atmospheric packaging technology which improves the shelf-life of these products.

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“…Suppression of NF-κB/MAPK and NLRP3 inflammasome activation in macrophages [267] Promotion of wound healing [115,116] Anti-cancer properties in methyl glyoxal modification [268] .Anti-proliferative activitiy on carcinogen-induced hepatotoxicity [269] Biofumigation of potato cyst nematode [33] Inhibition of Listeria monocytogenes on bologna sausages [263] Suppression of metastasis via inhibition of invasion, migration, and MMP-2/-9 activities in SK-Hep 1 human hepatoma cells [270] Brussel sprout juice mediatedeffects on cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro [271] AITC mediated mitotic block, loss of cell adhesion/disrupted cytoskeleton in HT29 cells [272] Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5 June 2019 doi:10.20944/preprints201906.0042.v1…”

Section: Reduction Of Liver Fibrosis [266]mentioning

confidence: 99%

The Glucosinolates, A Sulphur Glucoside Family of Mustard Phytochemicals With Diverse Biomedical Application

Melrose¹

2019

Preprint

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This study reviewed aspects of the biology of two members of the glucosinolate family, namely sinigrin and glucoraphanin and their potential biomedical therapeutic and industrial applications. Sinigrin and glucoraphanin are converted by the -sulphoglucosidase myrosinase or the gut microbiota into their bioactive forms, allyl isothiocyanate (AITC) and sulphoraphanin (SFN) which constitute part of a sophisticated defence mechanism plants have developed over several hundred million years of evolution to protect them from parasitic attack from aphids, ticks and nematodes.These compounds display biological activities in a number of mammalian physiological processes and potential biotherapeutic application. Glucosinolates may be useful in bio-fumigation and treatment of biofilms which occur on plant equipment and medical implants formed by problematic pathogenic bacteria such as Pseudomonas aeruginosa. AITC and SFN display similar antibiotic activity as Vancomycin in the treatment of bacteria listed by the World Health Organization as antibiotic-resistant "priority pathogens".AITC and SFN also display bioactivity in cancer chemoprevention through the induction of phase II antioxidant enzymes which inactivate potential carcinogens. The glucosinolates have found application in the prevention of bacterial and fungal spoilage of food substances during processing and in advanced food packaging formats which improve the shelf-life of food products.

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Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages

Cited by 46 publications

References 46 publications

Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF‐κB signaling pathway

Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF‐κB signaling pathway

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

The Glucosinolates, A Sulphur Glucoside Family of Mustard Phytochemicals With Diverse Biomedical Application

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