As soon as human increased usage of different radio transmitters and everybody can use cell phones, GPS, wireless internet, Bluetooth and similar to them systems started interesting topic -how does different kind of high frequency modulated signals can affect biological systems and human live vital organs [1,2]. In article [3] the influence of the continuous and pulsed microwaves at 2.45 GHz on different parts of human and animal body were analysed. The tissue of a heart, in the normal state possesses anisotropic properties; however, the anisotropy of heart tissue grows with some illnesses [4]. We investigated earlier only the isotropic heart models [5-7].Here we present the analysis of the anisotropic heart model.The electrodynamical rigorous solution of Maxwell's equations related to the microwave pulse propagation inside a three-dimension heart model with anisotropic and isotropic media is presented here. The model heart was limited by a non-coordinate shape surface and it consisted of two different size cavities. The heart cavities were schematic images of the left and right atriums and ventricles ( Figure 1). The myocardium tissue media is an anisotropic lossy medium and blood is an isotropic lossy medium. The boundary problem was solved by using the singular integral equations' (SIE) method. The distributions of electric field for the anisotropic and isotropic heart models are compared here.