Singlet Molecular Oxygen Generation via Unexpected Emission Color-Tunable CdSe/ZnS Nanocrystals for Applications in Photodynamic Therapy

Khan, Zahid Ullah; Khan, Latif Ullah; Uchiyama, Mayara Klimuk; Prado, Fernanda Manso; Faria, Rodrigo L.; Costa, Israel F.; Miyamoto, Sayuri; Araki, Koji; Gidlund, Magnus; Brito, Hermi F.; Mascio, Paolo Di

doi:10.1021/acsanm.2c05482

Cited by 3 publications

(52 citation statements)

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“…We found different decay values for singlet oxygen in water and chloroform, which were found to be consistent with that for the 1 O 2 previously reported at 3.5 μs (in water) 7 and 215 μs (in chloroform). 5 The observed different lifetimes of 1 O 2 in water and chloroform (Figure 6e,f) were attributed to a different energy transfer from electronic states of 1 O 2 to vibrational states of solvent molecules. The 1 O 2 generation via TET was further confirmed by using α- The 1 O 2 generation is also strongly dependent on the type of doping species, surface chemistry, and concentration of QDs.…”

Section: Development Of Qds-based Sensitizersmentioning

confidence: 95%

“…The reported studies have revealed that it usually occurs through the triplet energy transfer pathway. 5 Thus, detailed optical properties along with an insight into the electronic structure are paramount to probe the sensitization mechanism of the singlet oxygen generation. X-ray absorption spectroscopy (XAS) is a highly elementspecific technique that probes efficiently the local atomic/ electronic structure of the photoabsorber (metal site) in NCs.…”

Section: Fundamental Optoelectronic Properties Of Qdsmentioning

confidence: 99%

“…Semiconductor QDs have been shown to be highly efficient sensitizers for 1 O 2 production either individually or functionalized with other inorganic materials or molecular sensitizers. ,,− Individually, QDs can be light activated to produce 1 O 2 via triplet energy transfer (TET) ,− or charge transfer ,,, or energy transfer from dopant defects to dioxygen. On the other hand, QDs functionalized with molecular acceptors involve QDs energy transfer to a molecular acceptor which subsequently sensitizes 1 O 2 production. ,− ,− Thus, QDs offers distinct advantages over the conventional molecular and inorganic nanosensitizers (i.e., polymeric NPs, plasmonic NPs, metallic NPs, lanthanide NPs, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, QDs functionalized with molecular acceptors involve QDs energy transfer to a molecular acceptor which subsequently sensitizes 1 O 2 production. ,− ,− Thus, QDs offers distinct advantages over the conventional molecular and inorganic nanosensitizers (i.e., polymeric NPs, plasmonic NPs, metallic NPs, lanthanide NPs, etc.) in terms of versatile sensitization of 1 O 2 generation by various mechanisms and fine-tuning of their optoelectronic properties by multiple parameters in the wide UV–vis and NIR-I (700–900 nm) and NIR-II (1000–1700 nm) regions. ,,,,,,,, …”

Section: Introductionmentioning

confidence: 99%

“…This review focuses on the recent developments in the QD-assisted emerging strategies for enhanced photosensitized 1 O 2 generation via different mechanisms: (i) direct energy transfer from the dark states/triplet states of QDs to ground-state oxygen producing 1 O 2 , ,− (ii) charge transfer from the QDs conduction band (CB) to dioxygen forming O 2 – • which subsequently interacts with the valence band (VB) to produce 1 O 2 , ,,, and (iii) QD–PS conjugates involving the QDs energy transfer to the PS via Förster resonance energy transfer (FRET), ,− ,− Dexter-like energy transfer (DET), or sequential triplet–triplet energy transfer (TTET), − which subsequently sensitize 1 O 2 generation. ,,− …”

Section: Introductionmentioning

confidence: 99%

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Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Khan,

Brito

et al. 2023

ACS Omega

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Singlet molecular oxygen ( 1 O 2 ) has been reported in wide arrays of applications ranging from optoelectronic to photooxygenation reactions and therapy in biomedical proposals. It is also considered a major determinant of photodynamic therapy (PDT) efficacy. Since the direct excitation from the triplet ground state ( 3 O 2 ) of oxygen to the singlet excited state 1 O 2 is spin forbidden; therefore, a rational design and development of heterogeneous sensitizers is remarkably important for the efficient production of 1 O 2 . For this purpose, quantum dots (QDs) have emerged as versatile candidates either by acting individually as sensitizers for 1 O 2 generation or by working in conjunction with other inorganic materials or organic sensitizers by providing them a vast platform. Thus, conjoining the photophysical properties of QDs with other materials, e.g., coupling/combining with other inorganic materials, doping with the transition metal ions or lanthanide ions, and conjugation with a molecular sensitizer provide the opportunity to achieve high-efficiency quantum yields of 1 O 2 which is not possible with either component separately. Hence, the current review has been focused on the recent advances made in the semiconductor QDs, perovskite QDs, and transition metal dichalcogenide QD-sensitized 1 O 2 generation in the context of ongoing and previously published research work (over the past eight years, from 2015 to 2023).

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Section: Development Of Qds-based Sensitizersmentioning

confidence: 95%

Section: Fundamental Optoelectronic Properties Of Qdsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Khan,

Brito

et al. 2023

ACS Omega

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Manipulation of Energy Migration in Upconversion Nanoparticles for Long-Lived Mn²⁺ Emission and Enhanced Singlet Molecular Oxygen Generation

Khan,

Prado

et al. 2024

ACS Appl. Nano Mater.

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Nanosensitizers having long-lived upconversion emission under near-infrared (NIR) excitation offer unique advantages in terms of reduced background noise and prolonged signal detection for deep tissue therapy of cancer. Herein, we demonstrate a systematic mechanism of energy migration toward achieving long-lived Mn 2+ upconversion emission in the multilayered core−shell−shell lattice of NaGdF 4 :Yb 3+ ,Tm 3+ ,Ca 2+ /NaGdF 4 :Yb 3+ ,Ca 2+ /NaGdF 4 :Mn 2+ upconversion nanoparticles (NPs), following the Yb 3+ → Tm 3+ → Gd 3+ → Mn 2+ intermetal ions energy transfer pathway. Furthermore, a rational design of nanosensitizer was achieved by incorporating Er 3+ ions into the intermediate shell of multishell NPs, which was subsequently conjugated with the Rose Bengal sensitizer to enable the enhancement in singlet molecular oxygen ( 1 O 2 ) generation under excitation of a 980 nm NIR laser. An intense higher-energy emission in the UV−blue visible region from Tm 3+ was achieved by optimizing the amount of Ca 2+ in the core−shell NPs, followed by subsequent energy migration to the Mn 2+ ion incorporated at the outer shell. The Mn 2+ ions were strategically doped in the outer shell of NPs to leverage the catalytic activities of Mn 2+ for H 2 O 2 decomposition and decrease the backward energy transfer to the Tm 3+ ion. Hence, this approach resulted in a long lifetime of Mn 2+ (∼34 ms), attributed to the spin-forbidden 4 T 1g → 6 A 1g transition within 3d 5 configuration. Additionally, the nanosensitizer demonstrated high 1 O 2 (∼0.39 μM) generation even at a very low concentration (5 μg/mL) under a laser power of 2 mW cm −2 . The hydrogenase-like catalytic activities of Mn 2+ exhibited significant oxygen production through decomposition of H 2 O 2 . Hence, these findings might contribute to the development of convenient multifunctional nanosensitizers for multimodal bioimaging and therapeutic features, including efficient 1 O 2 generation and catalytic decomposition of H 2 O 2 (found excessively in a tumor environment) to oxygen for alleviating the hypoxia.

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A comprehensive review of lessons learned from quantum dots in cancer therapy

Mohammadi,

Hheidari,

Sardari

et al. 2024

Biomed. Mater.

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Quantum dots (QDs) are with exceptional physicochemical and biological properties, making them highly versatile for a wide range of applications in cancer therapy. One of the key features of QDs is their unique electronic structure, which gives them functional attributes. Notably, their photoluminescence can be strong and adjustable, allowing them to be effectively used in fluorescence based diognosis such as biosensing and bioimaging. In addition, QDs demonstrate an impressive capacity for loading cargo, making them ideal for drug delivery applications. Moreover, their ability to absorb incident radiation positions QDs as promising candidates for cancer-killing techniques like photodynamic therapy. The objective of this comprehensive review is to present a current and comprehensive overview of the recent advancements in utilizing QDs as multifunctional and innovative biomaterials. This review focuses on elucidating the biological, electronic, and physicochemical properties of QDs, along with discussing the technical advancements in QD synthesis. Furthermore, it thoroughly explores the progress made in utilizing QDs for diagnosis based on biosensing, bioimaging, and therapy applications including drug delivery and necrosis, highlighting their significant potential in the field of cancer treatment. Furthermore, the review addresses the current limitations associated with QDs in cancer therapy and provides valuable insights into future directions, thereby facilitating further advancements in this field. By presenting a comprehensive and well-structured overview, this review serves as an authoritative and informative resource that can guide future research endeavors and foster continued progress in the field of QDs for cancer therapy.

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Singlet Molecular Oxygen Generation via Unexpected Emission Color-Tunable CdSe/ZnS Nanocrystals for Applications in Photodynamic Therapy

Cited by 3 publications

References 75 publications

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Manipulation of Energy Migration in Upconversion Nanoparticles for Long-Lived Mn²⁺ Emission and Enhanced Singlet Molecular Oxygen Generation

A comprehensive review of lessons learned from quantum dots in cancer therapy

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Singlet Molecular Oxygen Generation via Unexpected Emission Color-Tunable CdSe/ZnS Nanocrystals for Applications in Photodynamic Therapy

Cited by 3 publications

References 75 publications

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Colloidal Quantum Dots as an Emerging Vast Platform and Versatile Sensitizer for Singlet Molecular Oxygen Generation

Manipulation of Energy Migration in Upconversion Nanoparticles for Long-Lived Mn2+ Emission and Enhanced Singlet Molecular Oxygen Generation

A comprehensive review of lessons learned from quantum dots in cancer therapy

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Manipulation of Energy Migration in Upconversion Nanoparticles for Long-Lived Mn²⁺ Emission and Enhanced Singlet Molecular Oxygen Generation