Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reovirus

Zhu, Bin; Liu, Guanglu; Gong, Yu-Xin; Ling, Fei; Song, Linsheng; Wang, Gao‐Xue

doi:10.1016/j.fsi.2014.09.014

Cited by 82 publications

(31 citation statements)

References 51 publications

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“…Nature of interaction within GO of CH and FMT was observed by FTIR spectroscopy (Figure b). After encapsulation of GO with CH, carbonyl stretching frequency in GO (1744 cm −1 ) was disappeared completely with emergence of new bands at 1682 and 1591 cm −1 , which suggested the amide linkage between GO and CH . FTIR spectrum of FMT showed vibration bands for amines (3506, 3400, and 3240 cm −1 ), imines (2343 cm −1 ) and SO (1147 cm −1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Some researchers worked on improvement of mechanical properties of chitosan with the help of inorganic nanofillers . Many researchers explored newer carrier systems such as metal and metal oxide nanoparticles, polymeric micelles, liposome's, dendrimers, and carbon nanotube, as targeting or controlling agents for expected drug release profile. Required characteristics of the carrier are binding sites for drug, biocompatibility, nontoxic nature, site specificity, safer elimination, and improved drug solubility .…”

Section: Introductionmentioning

confidence: 99%

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Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

et al. 2019

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This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

et al. 2019

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“…Antiviral or virucidal activities of these carbon-based nanomaterials have been evaluated against some viruses such as Ebola virus (pseudotyped viral particles), Bacteriophage λ, HIV-1, H3N2, Grass carp reovirus (GCRV) and Respiratory syncytial virus (RSV). [87][88][89][90][91] Various modes of viral inhibition by carbon-based nanomaterials used as carriers are represented in Table 1. Advancement in the evaluation of carbonbased nanosystems against viral infection, though have developed immensely, but their commercialization is a rate-limiting phase and will be resolved with respect to time.…”

Section: Carbon-based Nanocarriersmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

108

107

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Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

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“…As the typical rhabdovirus, SVCV G protein is the most commonly protein used in SVCV vaccine constructs [13]. As a promising carrier, single-walled carbon nanotubes (SWCNTs) has been widely used for antigens and drugs delivery attributable to its excellent properties, such as biocompatibility, needle-like structure, and high carrying capacity [14][15][16]. Specifically, SWCNTs are uniquely equipped to deliver cargos (such as antigens and drugs) across biological membranes [17], their use for vaccination could allow effective utilization of antigens that have previously not been able to induce adequate or appropriate responses, as well as providing significant means of enhancing and modulating immune response [18].…”

Section: Introductionmentioning

confidence: 99%

Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism

2020

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Background: Targeted delivery of virus-associated antigens to professional antigen-presenting cells (APCs) is considered as an efficient strategy to enhance the pyrophytic effect of vaccines against rhabdovirus disease. Materials and methods:In this study, we constructed a targeted carbon nanotubes-based vaccine deliver system (SWCNTs-MG) which can recognize the signature receptor (mannose) of APCs. An environmentally and economically important disease called spring viremia of carp (SVC) was studied as a model to evaluate the feasibility of singlewalled carbon nanotubes (SWCNTs) conjugated with mannosylated antigen for rhabdovirus prevention.Results: Results showed that SWCNTs-MG could cross into fish body and present to internal immune-related tissues through gill, muscle and intestine within 6 h immersed vaccination. With further modification of mannose moiety, the obtained nanovaccine showed enhanced uptake by carp macrophages and immune-related tissues, which would then trigger strong immune responses against spring viremia of carp virus (SVCV) infection. Moreover, the survival rate of fish vaccinated with SWCNTs-MG (30 mg/L) was 63.5% after SVCV infection, whereas it was 0% for the control group. Conclusion:This study not only provide a theoretical basis and research template for the application of targeted nanovaccine system in aquatic animals, but also play an important role in supporting development of healthy aquaculture and ensuring the safety of aquatic products and ecology.

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Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reovirus

Cited by 82 publications

References 51 publications

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier

Nano-based approach to combat emerging viral (NIPAH virus) infection

Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism

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