Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent

Pramanik, Manojit; Swierczewska, Magdalena; Green, Danielle; Sitharaman, Balaji; Wang, Lihong V.

doi:10.1117/1.3147407

Cited by 158 publications

(137 citation statements)

References 42 publications

(50 reference statements)

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“…[8][9][10][11][12][13] Recently, investigations have sought to improve PAT/TAT performance. [14][15][16][17] The results showed that PAT/TAT was capable of high-resolution structural, functional, and molecular imaging that was free of speckle artifacts. Combinations of PAT/TAT or PAT/US were investigated for breast cancer and sentinel lymph node imaging.…”

Section: Introductionmentioning

confidence: 86%

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

Erpelding

Jankovic

et al. 2012

J. Biomed. Opt

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Abstract. We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached ∼24 and ∼15 dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm.

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Section: Introductionmentioning

confidence: 86%

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

Erpelding

Jankovic

et al. 2012

J. Biomed. Opt

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“…SWNTs can offer more than twofold signal amplification in thermoacoustic tomography (TAT) and more than sixfold signal enlargement in photoacoustic tomography (PAT) compared with control. Due to SWNTs being able to give maximum signal compared with other carbon materials, fullerenes, and graphitic microparticles, this characteristic makes them applicable in the PAI as ideal contrast-mediums [78].…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

The Advances of Carbon Nanotubes in Cancer Diagnostics and Therapeutics

Zhou

Zhang

Wang

et al. 2017

Journal of Nanomaterials

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Carbon nanotubes (CNTs), one of the unique one-dimensional nanomaterials, have gained great attention because of their specific characters, versatile functionalization chemistry, and biological compatibility in the past few decades. CNTs can be functionalized via different methods to perform their specific functions. CNTs have been used in various areas of biomedicine as nanocarriers, including cancer diagnosis and therapy. Different molecules such as peptide, antigen, and nucleic acid can be delivered to cancer cells by CNTs with high efficiency. In this review, we summarized the properties of CNTs and the method of CNTs functionalization and illustrated their application in cancer diagnosis and therapy.

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“…Carbon nanomaterials have been considered as potential biomedical materialsfor pharmaceutical, biomedical, [357,358] and bio-imaging applications, [359][360][361][362] including PAI [363][364][365][366][367][368][369][370][371][372] and thermo-acoustic imaging [373]. The characteristic optical properties of SWNTs, particularly those with optical properties in the NIR region, [374] play an important role in photoacoustic imaging [375].…”

Section: Carbon Nanomaterialsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent

Cited by 158 publications

References 42 publications

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

The Advances of Carbon Nanotubes in Cancer Diagnostics and Therapeutics

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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