Single-walled carbon nanotube-gold urchin nanohybrid for identifying gastric cancer on dimicroelectrodes junction

Yu, Zhihong; Gopinath, Subash C.B.; Lakshmipriya, Thangavel; Anbu, Periasamy

doi:10.1016/j.jtice.2021.04.016

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…This system is quite feasible with the same operating set-up for analysing clinically relevant real samples. With the similar sensing system on different modifications, the genuine detections have been demonstrated as the evidence using human serum [ 22 , 36 , 37 ]. According to these recent studies, the primary optimization step is necessary with different surface modifications to be suited for the desired measurement ranges.…”

Section: Resultsmentioning

confidence: 99%

Current-Volt Biosensing “Cystatin C” on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta

Chen

Kang

Sun

et al. 2022

Journal of Analytical Methods in Chemistry

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A carbon nanowire-modified surface with interdigitated electrode (IDE) sensing system was introduced to identify abdominal aortic aneurysm biomarker “papain,” also known as cysteine protease, used as the capture probe to identify Cystatin C. Papain was immobilized through the covalent integration of amine group on papain and the carboxyl group with carbon nanowire. This papain-modified electrode surface was utilized to detect the different concentrations of Cystatin C (100 pg/mL to 3.2 ng/mL). The interaction between papain and Cystatin C was monitored using a picoammeter, and the response curves were compared. With increasing Cystatin C concentrations, the total current levels were gradually increased with a linear range from 200 pg/mL to 3.2 ng/mL, and the current differences were plotted and the detection limit of Cystatin C was calculated as 200 pg/mL. The averaging of three independent experiments (n = 3) was made with 3δ estimation, and the determination coefficient was y = 1.8477 × 0.7303 and R2 = 0.9878. Furthermore, control experiments with creatinine and gliadin failed to bind the immobilized papain, indicating the specific detection of Cystatin C.

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Section: Resultsmentioning

confidence: 99%

Current-Volt Biosensing “Cystatin C” on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta

Chen

Kang

Sun

et al. 2022

Journal of Analytical Methods in Chemistry

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“…The nanodiamond-antibody modification was affixed to the IDE surface through APTES [ 33 ], which facilitates the formation of a self-assembled monolayer. The following steps were employed for this process: (i) 1 % potassium hydroxide (KOH) was added to the IDE surface to create a hydroxyl-tethered surface, allowing it to rest for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Nanoquantification of RUNX2 by a 1,1′-carbonyldiimidazole-diamond mediated sandwich assay for osteogenic differentiation

Sun,

Zhu,

Shi

et al. 2024

Heliyon

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“…To improve the detection of target DNA, in 2021, Yu et al attached a DNA sequence from the SOX-17 gene onto a gold urchin (DNA-GU), linking it to a single-walled carbon nanotube (SWCN)-constructed DMEs junction (DMEJ) [58]. The biosensor demonstrated exceptional sensitivity, detecting DNA concentrations ranging from 1 aM to 10 fM.…”

Section: Dna Nanobiosensors In Gcmentioning

confidence: 99%

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

Avanu,

Ciubotariu,

Dodi

2024

Chemosensors

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Gastric cancer (GC) remains a significant global health challenge, with late-stage diagnosis impacting treatment options and decreased survival rates. To address this, there has been a growing interest in the development of innovative screening and diagnostic methods. Over the past 20 years, nanobiosensors have undergone multiple iterations and unveiled remarkable features that pledge to reshape patient care. Despite the excitement over the plethora of ground-breaking advancements for cancer detection, use-ready samples and streamlined healthcare information monitoring and usage, this technology is still awaiting entry into clinical trials, urging a closer gaze within the medical community. Oligonucleotide-based biosensors, leveraging DNA or RNA’s long-term storage of information, offer great specificity and sensitivity, as described throughout this paper. Consequently, this renders them as an ideal choice for revolutionizing GC diagnosis and facilitating early intervention. The aim of this review is to provide an overview of this cutting-edge, invaluable technology and its limitations across various aspects.

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Single-walled carbon nanotube-gold urchin nanohybrid for identifying gastric cancer on dimicroelectrodes junction

Cited by 11 publications

References 31 publications

Current-Volt Biosensing “Cystatin C” on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta

Current-Volt Biosensing “Cystatin C” on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta

Nanoquantification of RUNX2 by a 1,1′-carbonyldiimidazole-diamond mediated sandwich assay for osteogenic differentiation

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

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